Results 101 to 110 of about 19,999 (251)

V(D)J Gene Usage and Binding Kinetics of the Anti-TT Hybridomas.

, 2014
ND = not determined.1Hybridoma 18–96 and 26 are clonally related.2P4T29115 was not evaluable on the IgG1-coated Biacore sensor because it is an IgG2a.3Hybridoma 6 and 14 are clonally related.V(D)J Gene Usage and Binding Kinetics of the Anti-TT Hybridomas.
Antonina G. Aydanian (636877), Mahsa Sorouri (636875), Sonita Bennett (636878), Sean P. Fitzsimmons (636876), Marjorie A. Shapiro (636879)   +4 more
core   +1 more source

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia

The Journal of Physiology, EarlyView.
Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +13 more
wiley   +1 more source

Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated Rejection

Cells
Donor-specific anti-HLA antibodies (DSAs) bind to donor vascular endothelial cells and mediate allograft rejection (AMR), but a clinical challenge for which targeted therapeutic options remain limited.
Jing Zhang, Leiyan Wei, Lei Song, Xiaofang Lu, Liang Tan, Xin Li, Li Fu, Qizhi Luo, Xubiao Xie, Yizhou Zou   +9 more
doaj   +1 more source

Hybridoma Technology

, 2022
Hybridoma technology combines the unique qualities of antibody-producing B cells with immortalized myeloma cells, creating hybrid cells capable of endless proliferation while retaining the ability to produce specific antibodies. The process begins with the immunization of a host animal, typically a mouse, followed by the fusion of its spleen cells ...
openaire   +2 more sources

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

The use of in vitro immunisation, as an adjunct to monoclonal antibody production, may result in the production of hybridomas secreting polyreactive antibodies

, 2001
The possibility that immortalisation of in vitro immunised splenocytes may result in hybridomas secreting polyreactive antibodies was investigated.
Michael J McMahon, McMahon, Michael J., O'Kennedy, Richard, Richard O'Kennedy   +3 more
core   +1 more source

RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Under normal conditions, RagD and mTORC1 respond to amino acid changes. Upon stimulation, active mTORC1 phosphorylates S6K, 4E‐BP1, and TFEB. In response to starvation, mTORC1 is inactive. Our data indicate that the RRAGD p.(Ser76Leu) variant maintains the phosphorylation of mTORC1 targets during starvation in T‐REx HeLa cells.
Anastasia Adella, Sara B. van Katwijk, Pieter A. Leermakers, Willem B. van Ham, Hesther de Ruiter, Judita Ilgutytė, Suzanne Hendrickx, Levi Nijland, Teun P. de Boer, Eva van Rooij, Joost G. J. Hoenderop, Jeroen H. F. de Baaij   +11 more
wiley   +1 more source

A simple technique to distinguish rat from mouse chromosomes in T cell hybridomas.

, 1988
Antigen-specific rat mouse T-cell hybridomas, prepared by fusing the BW5147 AKR thynoma with helper T cells from rats immunized with chicken ovalbumin, express both the rat and mouse major histocompatibility complex gene products.
Simon, D, Heber, Katz E, Knowles, B B, Valentine, S   +3 more
core  

A study of antibody secretion from hybridoma cells [PDF]

, 1988
The secretion of monoclonal antibody in both batch and continuous cultures was studied. It was found that when hybridoma cells were continuously cultivated in a simple lab scale fermenter, they secreted less antibody than cells grown in stationary ...
Holland, P.N.
core