Results 111 to 120 of about 3,737 (192)

Secondary cartilage in the murine medial pterygoid plate has a critical role in the pathfinding of the tensor veli palatini

Journal of Anatomy, Volume 249, Issue 4, Page 759-768, October 2026.
The development of the medial pterygoid plate (MPP) is followed in mouse embryos, highlighting its neural crest origin and complex development via both endochondral and membranous ossification. Using transgenic mice, the secondary cartilage of the MPP is shown to direct the path of the tensor veli palatini.
Luke A. Barlow, Emi Nomura, Abigail S. Tucker   +2 more
wiley   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Virus-like Particles and Spectral Flow Cytometry for Identification of Dengue Virus-Specific B Cells in Mice and Humans

Viruses
Severe dengue virus (DENV) infections are associated with circulating non-neutralizing antibodies generated during heterotypic infections. Although antibodies are key mediators of both protection and pathogenesis, the specific dynamics of B cells (Bc ...
Katherine Segura, Fabiola Martel, Manuel A. Franco, Federico Perdomo-Celis, Carlos F. Narváez   +4 more
doaj   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, Volume 13, Issue 50, 7 September 2026.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Development and Evaluation of Monoclonal Antibodies against CBPP Antigen with the End Goal of Developing an ELISA Kit

Veterinary Medicine International
Contagious bovine pleuropneumonia (CBPP) is an infectious and contagious bacterial respiratory disease that affects cattle with significant economic losses to the African animal industry.
Lorato Ramathudi-Dunbar, Emmanuel Awosanya, Sanne Bodjo Charles, Ethel Chitsungo, Cisse Rahamatou Moustapha Boukary, Nick Nwankpa, Hassen Gelaw, Yebechaye Tessema, Gelagay Melesse A., Richard Rayson Sanga, Adorbley Bright, Jean de Dieu Baziki   +11 more
doaj   +1 more source

More efficient generation of neutralizing hybridomas against IL-21 from the alternating-antigen approach.

, 2019
(A, C, and E) hybridomas isolated from the alternating antigen approach. (B, D and F) hybridomas isolated from the single antigen approach. (A, B) Binding ELISA results of human and cyno IL-21 cross-reactive hybridoma supernatants.
Rachel Ettinger (6264008), Herren Wu (166537), Melissa Damschroder (166551), Reena Varkey (6263996), Xiaodong Xiao (360835), Qun Du (6263999), Rob Woods (1536871), William F. Dall’Acqua (654947), Kim Rosenthal (694648), Ronald Herbst (611168), Kerry A. Casey (6264005), Susan Wilson (134263), Jodi L. Karnell (6264002)   +12 more
core   +1 more source

Analysis of the Role of N‐Linked Glycans on Human CD1d Molecules

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT CD1d is a cell‐surface expressed glycoprotein that presents a variety of lipid and glycolipid antigens to invariant natural killer T‐cells (iNKT). We have examined the role of the N‐linked glycans on the human CD1d (hCD1d) in modulating the responses of iNKT cells using a combination of cell‐free, cell‐based assays and in silico analyses ...
Syamdas Bandyopadhyay, Sayantan Pradhan
wiley   +1 more source

Optimization of electrofusion parameters for producing hybridomas synthesizing human monoclonal antibodies

, 2021
Monoclonal antibodies are an established treatment for many diseases, including cancer, toxic conditions and infectious diseases. The goal of this work was to optimize the conditions for obtaining hybridomas secreting human monoclonal IgG antibodies.
Silkina M. V.
core  

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

Glia, Volume 74, Issue 9, September 2026.
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko, Shu‐Hui Chu, Angela Gomez‐Arboledas, Blossom Zhang, Andrea J. Tenner   +4 more
wiley   +1 more source