Results 121 to 130 of about 3,737 (192)

Induction of long-term but reversible unresponsiveness after activation of murine T cell hybridomas.

, 1991
T cell receptor (TCR)-mediated stimulation of murine T cell hybridomas induces cell activation and lymphokine production. We have observed that following productive activation, T cell hybridomas become refractory to a subsequent stimulation ...
Kaufman, Marcelle, Leo, Oberdan, Andris, Fabienne, Van Mechelen, Marcelle, Legrand, N, Dubois, Patrice, Urbain, Jacques   +6 more
core   +1 more source

Molecular Mechanisms and Therapeutic Applications of Extracellular Vesicles in Remodeling of the Skin Cancer Niche

Nano Select, Volume 7, Issue 9, September 2026.
Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian, Maria Nison, Deepanjan Datta, Soniya Kumbham, Namdev Dhas, Praveen Halagali, Vasudev R Pai, Vamshi Krishna Tippavajhala   +7 more
wiley   +1 more source

Generation of the first monoclonal antibody using mouse hybridomas

Haematologica, 2022
Brunangelo Falini
doaj   +1 more source

Aging Alters Hair Cell Physiological Properties in Mice With Late‐Onset Age‐Related Hearing Loss

Aging Cell, Volume 25, Issue 9, September 2026.
Hidden hearing loss during aging is associated with peripheral auditory system decline. We discovered that aging sensory hair cells decrease in size. In addition, inner hair cells exhibit a reduced K+ current carried out by BK channels, accompanied by an elevated resting membrane potential, suggesting an age‐related functional impairment.
Piece Yen, Adam J. Carlton, Andrew O'Connor, Niovi Voulgari, Stuart L. Johnson, Jing‐Yi Jeng   +5 more
wiley   +1 more source

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

, 1995
A number of murine T-cell hybridomas undergo apoptosis within a few hours of activation by specific antigens, mitogens, antibodies against the T-cell antigen receptor, or a combination of phorbol ester and calcium ionophore.
Nam Jin Yoo, LaFace, Drake, Force, Walker, Lynch, David H., Brunner, Thomas, Artin Mahboubi, Douglas R. Green, Ware, Carl F., Carl F. Ware, Force, Walker R., Thomas Brunner, Green, Douglas R., Martin, Seamus J., Yoo, Nam Jin, Walker R. Force, Green, Douglas, Echeverri, Fernando, David H. Lynch, Mogil, Rona, Mogil, Rona J., Seamus J. Martin, Martin, Seamus, Lynch, David, Drake LaFace, Mahboubi, Artin, Rona J. Mogil, Fernando Echeverri, Ware, Carl   +27 more
core   +1 more source

MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation

Allergy, Volume 81, Issue 9, Page 3236-3249, September 2026.
In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata, Jaclyn W. McAlees, Julie M. Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P. Lewkowich   +6 more
wiley   +1 more source

Reduced Expression of Magnesium Transport Proteins in the Distal Convoluted Tubule of Clcnkb‐Deficient Mice May Explain Urinary Magnesium Wasting in Classical Bartter Syndrome

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim The kidney thick ascending limb (TAL) plays a key role in the transport of sodium, chloride, potassium, calcium, and magnesium. Bartter syndrome is a hypokalemic, salt‐losing tubulopathy caused by impaired TAL function. Pathogenic variants in SLC12A1 or KCNJ1 cause antenatal Bartter syndrome, and variants in CLCNKB result in classical ...
Marleen L. A. Kortenoeven, Milos Bogdanovic, Ida Appel, Karsten Skjødt, Ernst‐Martin Fuchtbauer, Kirsten Madsen, Lars Lund, Régine Chambrey, Dominique Eladari, R. Todd Alexander, Christian A. Hübner, J. Christopher Hennings, Henrik Dimke   +12 more
wiley   +1 more source

Protective and Pathogenic Antibodies to Citrullinated Antigens

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila, Yibo He, Zhongwei Xu, Changrong Ge, Erik Lönnblom, Rikard Holmdahl   +5 more
wiley   +1 more source

A semi‐automated pipeline for quantitation of Pax7+, myonuclei, and cross‐sectional area by fiber type

Physiological Reports, Volume 14, Issue 18, September 2026.
Created in BioRender. Megowan, H. (2026) https://BioRender.com/9457v5e. Abstract Manual analysis of skeletal muscle cross‐sections is time‐consuming and subject to error and user bias. To overcome these limitations, we developed and validated a semi‐automated, quantitative, and reproducible image‐analysis pipeline specifically tailored to quantify Pax7+
Helia G. Megowan, Madeline Luu, Adam Shuaib, Kaitlyn B. Augienello, Adam C. Fries, Jake Searcy, Hans C. Dreyer   +6 more
wiley   +1 more source

A monoclonal antibody collection for C. difficile typing ?

Gut Pathogens
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles. However, most
Lise Hunault, Patrick England, Frédéric Barbut, Bruno Iannascoli, Ophélie Godon, François Déjardin, Christophe Thomas, Bruno Dupuy, Chunguang Guo, Lynn Macdonald, Guy Gorochov, Delphine Sterlin, Pierre Bruhns   +12 more
doaj   +1 more source