Results 121 to 130 of about 19,999 (251)

Studying on creation of hybridomas producing monoclonal antibody specific for progesteron

, 2012
The progesterone highest level is reached on the 21st and 22nd days of pregnancy. The concentrations of progesterone in milk and serum can be quantitatived.
Phuong, Do Thi, Thao, Do Thi, Do Thi Thao, Trang, Nguyen Thi, Cu, Nguyen Thi, Nguyen Thi Cu, Do Thi Phuong, Nguyen Thi Trang   +7 more
core   +1 more source

Genetically Programmed Control of Overflow Metabolism

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1624-1633, June 2026.
ABSTRACT Overflow metabolism is a highly undesirable phenomenon that occurs in virtually all cell factories. Although several schemes have been applied to avoid overflow metabolism, this problem remains far from being solved. In this study, a genetic sensor for detecting overflow metabolism was designed, and its substrate specificity and reversibility ...
Lærke M. Jensen, Andriy Glushchuk, Thilde P. Hjorth, Alvaro R. Lara   +3 more
wiley   +1 more source

Control of serum protein production in hepatocyte hybridomas: immortalization and expression of normal hepatocyte genes.

, 1980
"Hepatocyte hybridomas" have been isolated after fusion of adult hepatocytes and alpha-fetoprotein (AFP)-producing mouse hepatoma cells. The yield of viable hybrid clones was low but could be increased by culturing the cells in the presence of insulin ...
Szpirer, Josiane, Wanson, Jean-Claude, Szpirer, Claude   +2 more
core   +1 more source

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This study explored the role of the class IIa histone deacetylase HDAC7 in hepatic inflammation and metabolic disease. Genetic approaches in mice revealed that myeloid HDAC7 drives hepatic inflammation and gene signatures associated with advanced chronic liver disease.
Yizhuo Wang, Divya Ramnath, Kaustav Das Gupta, P Prakrithi, Kavita Bisht, Gregory C Miller, Zherui Xiong, Yujun Wan, Ellen N Tejo, James EB Curson, Rishika Abrol, Sahar Keshvari, Kimberley S Gunther, Jordan D Atkinson, Zhixuan Loh, Jessica A Engel, Christian R Engwerda, Sabrina Sofia Burgener, Kate Schroder, David P Fairlie, Andrew D Clouston, Elizabeth E Powell, Katharine M Irvine, Mitchell A Sullivan, Jean‐Pierre Lévesque, Quan Nguyen, Matthew J Sweet, Denuja Karunakaran   +27 more
wiley   +1 more source

Screening individual hybridomas by microengraving to discover monoclonal antibodies

, 2009
The demand for monoclonal antibodies (mAbs) in biomedical research is significant, but the current methodologies used to discover them are both lengthy and costly.
Ogunniyi, Adebola Oluwakayode, Guillen, Eduardo, Eliseo Papa, Eduardo Guillen, Story, Craig M., Papa, Eli, Craig M Story, Love, J. Christopher, Adebola O Ogunniyi, J Christopher Love   +9 more
core   +1 more source

Activation properties of T cell receptor-gamma delta hybridomas expressing diversity in both gamma- and delta-chains.

, 1988
To elucidate the structure, diversity, and activation properties of the murine T3-associated gamma delta-receptor, examination was made of the gamma delta and T3 components, T cell receptor (TCR) gene transcription, activation properties, and lymphokine ...
Pardoll, D, Leo, Oberdan, Coligan, J, Fowlkes, B J, Kruisbeek, A M, Germain, R N, Saito, T, Schwartz, R H, Marusić-Galesić, S   +8 more
core  

Monoclonal antibodies multireactive with parasite antigens produced by hybridomas generated from naive mice

, 1997
Hybridoma clones producing IgM naturally occurring (natural) antibodies were generated from naive Balb/c mice and characterized for reactivity against parasite antigens.
E. KONISHI
core   +1 more source

Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer

International Journal of Cancer, Volume 158, Issue 11, Page 3038-3050, 1 June 2026.
What's new? Pancreatic ductal adenocarcinoma is characterized by a dense extracellular matrix, and how invasive tumor cells overcome such biomechanical constraints remains unclear. This study identifies the actin‐related protein 2/3 complex as a key regulator of pancreatic ductal adenocarcinoma invasiveness, driving fibroblast migration through β1 ...
Xiufen Yang, Yina Qiao, Yifeng Sun, Tamer Abdelaal, Kathleen Schuck, Hend Abdelrasoul, Carolina De La Torre, Malte Hermes, Yan Dong, Jingxiong Hu, Chao Fang, Xiaoyan Huang, Christoph Kahlert, Ingrid Herr, Christoph W. Michalski, Bo Kong   +15 more
wiley   +1 more source

A cell sorter with modified bamboo charcoal for the efficient selection of specific antibody-producing hybridomas

, 2010
[[abstract]]Monoclonal antibodies (mAbs) have been proven useful in research and clinical applications. However, the generation of mAbs by conventional hybridoma technology is time-, cost- and labor-consuming. Here we developed a simplified procedure for
Lin, CC;Ni, MH;Chang, YC;Yeh, HL;Lin, FH
core   +1 more source

Enterococcus faecalis Extracellular Vesicles Deliver the Bacterial GTPase Obg to Hijack mTOR Signalling in Hepatocellular Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
E. faecalis is enriched in HCC tissue and can promote liver tumourigenesis by activating mTOR signalling pathway. Obg derived from E. faecalis extracellular vesicles (EVs) is a GTPase physically interacts with mTOR, and acts as an interkingdom activator of mTOR. EF‐Obg expression level in HCC tissue correlates with poor prognosis in HCC patients.
Ning Ma, Xiaoshan Xie, Jiarui Wang, Zhikai Zheng, Huilin Jin, Xijie Chen, Xiaoling Huang, Haidan Luo, Yue Wei, Qihao Pan, Boyu Zhang, Jiaying Zheng, Peng Zhang, Fenghai Yu, Xue Liu, Zhi‐Min Zhang, Zhongguo Zhou, Xiangqi Meng, Mong‐Hong Lee   +18 more
wiley   +1 more source