Results 91 to 100 of about 34,653 (293)
Cotransfer of the Eαd and Aβd genes into L cells results in the surface expression of a functional mixed-isotype Ia molecule [PDF]
, 1986 Ia molecules play a key role in antigen recognition by T lymphocytes. To analyze the structural features of the individual α and β chains relevant to the assembly of intact Ia molecules, mouse fibroblasts were contransfected with various combinations of ...
Hood, Leroy +3 more
core
British Journal of Pharmacology, EarlyView.Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda +5 more
wiley +1 more source
The FEBS Journal, EarlyView.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs +7 more
wiley +1 more source
, 1986 The proliferative capacity of gland cells in Hydra attenuata was investigated. The results indicate that both gland cell proliferation and interstitial cell differentiation to gland cells contribute to the maintenance of the whole population.
David, Charles N., Schmidt, Tobias
core
The FEBS Journal, EarlyView.Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia +7 more
wiley +1 more source
VacciMonitor, 2011 Neisseria meningitidis isolates are conventionally classified by serosubtyping that characterizes the reactivities of the PorA outer membrane protein variable-region epitopes with monoclonal antibodies.
María Elena Pérez +8 more
doaj
Journal of Anatomy, EarlyView.The development of the medial pterygoid plate (MPP) is followed in mouse embryos, highlighting its neural crest origin and complex development via both endochondral and membranous ossification. Using transgenic mice, the secondary cartilage of the MPP is shown to direct the path of the tensor veli palatini.
Luke A. Barlow +2 more
wiley +1 more source
Screening individual hybridomas by microengraving to discover monoclonal antibodies [PDF]
, 2009 The demand for monoclonal antibodies (mAbs) in biomedical research is significant, but the current methodologies used to discover them are both lengthy and costly.
Guillen, Eduardo +4 more
core +1 more source
The Journal of World Intellectual Property, EarlyView.Abstract Between 2001 and 2021, pharmaceutical patent applications filed in Brazil were examined by the patent office (INPI) and the national health regulator (Anvisa). This paper investigates how health regulators can contribute to patent examination by shifting the set of criteria cited as grounds for 2589 negative decisions from both entities ...
Eduardo Mercadante
wiley +1 more source
Variations in “rescuability” of immunoglobulin molecules from different forms of human lymphoma: implications for anti-idiotype vaccine development [PDF]
, 2004 Idiotypic (Id) vaccination has shown promising results in patients with follicular lymphoma (FL). However, it still remains unclear whether the same approach might be suitable for the treatment of other B-cell malignancies.
Bendandi, M. (Maurizio) +5 more
core +1 more source