Results 1 to 10 of about 31,338 (264)

Novel Role of Gestational Hydralazine in Limiting Maternal and Dietary Obesity-Related Chronic Kidney Disease

Frontiers in Cell and Developmental Biology, 2021
BackgroundMaternal obesity is a risk factor for chronic kidney disease (CKD) in offspring, underpinning the theory of the developmental origins of health and disease.
Benjamin P. Larkin, Long T. Nguyen, Miao Hou, Sarah J. Glastras, Sarah J. Glastras, Hui Chen, Rosy Wang, Carol A. Pollock, Sonia Saad, Sonia Saad   +9 more
doaj   +2 more sources

Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.

PLoS ONE, 2021
BackgroundMaternal high fat diet (HFD) promotes chronic kidney disease (CKD) in offspring. This is in accordance with the theory of fetal programming, which suggests adverse conditions occurring in utero predispose offspring to chronic conditions later ...
Benjamin P Larkin, Sonia Saad, Sarah J Glastras, Long T Nguyen, Miao Hou, Hui Chen, Rosy Wang, Carol A Pollock   +7 more
doaj   +2 more sources

Isosorbide dinitrate, with or without hydralazine, does not reduce wave reflections, left ventricular hypertrophy, or myocardial fibrosis in patients with heart failure with preserved ejection fraction [PDF]

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background-Wave reflections, which are increased in patients with heart failure with preserved ejection fraction, impair diastolic function and promote pathologic myocardial remodeling.
Akers, Scott, Beraun, Melissa, Chirinos, Julio A., Chittams, Jesse, Haines, Philip G., Koppula, Maheswara R., Rawat, Deepa, Segers, Patrick, Shiva-Kumar, Prithvi, Soto-Calderon, Haideliza, Townsend, Raymond R., Varakantam, Swapna, Witschey, Walter R., Zamani, Payman   +13 more
core   +2 more sources

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

Frontiers in Neurology, 2019
Although the pathogenic mechanisms of Parkinson's disease (PD) remain unclear, ample empirical evidence suggests that oxidative stress is involved in the pathogenesis of this disease.
Xingfang Guo, Chao Han, Kai Ma, Yun Xia, Fang Wan, Sijia Yin, Liang Kou, Yadi Sun, Jiawei Wu, Junjie Hu, Jinsha Huang, Nian Xiong, Tao Wang   +12 more
doaj   +2 more sources

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Nature Communications, 2017
Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C.
Esmaeil Dehghan, Yiqiang Zhang, Bahar Saremi, Sivaramakrishna Yadavali, Amirmansoor Hakimi, Maryam Dehghani, Mohammad Goodarzi, Xiaoqin Tu, Scott Robertson, Rueyling Lin, Asish Chudhuri, Hamid Mirzaei   +11 more
doaj   +2 more sources

Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia: a randomized control trial [version 2; peer review: 2 approved]

F1000Research, 2023
Background: Preeclampsia is a highly prevalent disease among pregnant women. In the event of hypertensive emergency, nifedipine, labetalol, and hydralazine are assigned as first-line therapies in preeclampsia.
Maya Savira, Dhini Aiyulie Novri, Yulis Hamidy, Donel S   +3 more
doaj   +2 more sources

Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome [PDF]

BMJ Case Reports, 2018
Hydralazine, a vasodilator, is commonly used as an adjunctive treatment for moderate to severe hypertension, heart failure and hypertensive emergencies in pregnancy. Hydralazine-induced lupus was first described in 1953. Clinical presentation ranges from
Aeddula, Narothama Reddy, Ansari, Asif, Juran, Peter J., Pathireddy, Samata   +3 more
core   +2 more sources

Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis [PDF]

Jornal Brasileiro De Nefrologia, 2018
Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil
Roman Zuckerman, Mayurkumar Patel, Eric J. Costanzo, Harry Dounis, Rany Al Haj, Seyedehsara Seyedali, Arif Asif   +6 more
openalex   +2 more sources

Hydralazine Attenuates Lipopolysaccharide-Induced Murine Myocardial Dysfunction by Inhibition of Semicarbazide-Sensitive Amine Oxidase [PDF]

Antioxidants
Sepsis-induced myocardial dysfunction (SIMD) is a fatal complication with limited therapeutic options. Semicarbazide-sensitive amine oxidase (SSAO) contributes to oxidative stress and leukocyte recruitment, yet its role in SIMD remains unexplored.
Zejian Kuang, Hongjun Luo, Hui Li, Yongyin Zhou, Zhexuan Lin, Wenhong Luo   +5 more
doaj   +2 more sources

Effect of the cholinergic system of the lateral periaqueductal gray (lPAG) on blood pressure and heart rate in normal and hydralazine hypotensive rats [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Due to the presence of the cholinergic system in the lateral periaqueductal gray (lPAG) column, the cardiovascular effects of Acetylcholine (ACH) and its receptors in normotensive and hydralazine (HYD) hypotensive rats in this area were ...
Atiyeh Ghorbani, Reza Mohebbati, Alireza Rahimi, Vida Alikhani, Mohammad Naser Shafei   +4 more
doaj   +3 more sources