Results 21 to 30 of about 12,705 (162)
PLoS ONE, 2021 BackgroundMaternal high fat diet (HFD) promotes chronic kidney disease (CKD) in offspring. This is in accordance with the theory of fetal programming, which suggests adverse conditions occurring in utero predispose offspring to chronic conditions later ...
Benjamin P Larkin +7 more
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Possible Therapeutic Options for Complex Regional Pain Syndrome
Biomedicines, 2021 Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma.
Myeounghoon Cha +3 more
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Antioxidants, 2023 A major hallmark of aging-associated diseases is the inability to evoke cellular defense responses. Transcriptional protein Nrf2 (nuclear factor erythroid-derived 2-related factor) plays a pivotal role in the oxidative stress response, cellular ...
Bhavana Chhunchha +3 more
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British Journal of Clinical Pharmacology, EarlyView.Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed +7 more
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Clinical Pharmacology &Therapeutics, EarlyView.NAT2 encodes arylamine N‐acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 ...
Bailey M. Tibben +10 more
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Floating tablets of hydralazine hydrochloride: optimization and evaluation
Brazilian Journal of Pharmaceutical Sciences, 2013 Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy.
Kondi Vanitha +2 more
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Hydralazine and Enzalutamide: Synergistic Partners against Prostate Cancer
Biomedicines, 2021 Advanced prostate cancers frequently develop resistance to androgen-deprivation therapy with serious implications for patient survival. Considering their importance in this type of neoplasia, epigenetic modifications have drawn attention as alternative ...
Nair Lopes +6 more
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Clinical Pharmacology &Therapeutics, EarlyView.The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John +4 more
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Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad +9 more
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Studies on the cardiovascular actions of hydralazine.
Acta Médica Portuguesa, 1979 In conscious normotensive rabbits, the intravenous administration of hydralazine (0.3 mg/Kg) induced a significant decrease of mean arterial blood pressure (MBP) (p 0.05) and did not modify the tachycardia.
Virgílio Durão, Assunção Elvas
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