Results 41 to 50 of about 15,167 (190)

Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.

PLoS ONE, 2021
BackgroundMaternal high fat diet (HFD) promotes chronic kidney disease (CKD) in offspring. This is in accordance with the theory of fetal programming, which suggests adverse conditions occurring in utero predispose offspring to chronic conditions later ...
Benjamin P Larkin, Sonia Saad, Sarah J Glastras, Long T Nguyen, Miao Hou, Hui Chen, Rosy Wang, Carol A Pollock   +7 more
doaj   +1 more source

Hydralazine-Induced Vasculitis

, 2023
Hydralazine is a commonly prescribed medication which is used in the treatment of hypertension. While it is generally considered to be a safe and effective treatment, in rare cases it can cause a serious side effect known as hydralazine-induced ...
Khurana, Bani, Sekar, Arjun, Gandhi, Roopali Goyal, Gandhi, Pulkit, Munjal, Ripudaman S   +4 more
core   +1 more source

Hydralazine-Associated Vasculitis and Pulmonary Hemorrhage.

, 2023
Hydralazine is a potent vasodilating medication used as adjunctive therapy for the treatment of hypertension. Rarely, hydralazine may cause the development of antineutrophil cytoplasmic antibody vasculitis with the pulmonary-renal syndrome.
Strubchevska, Kateryna, Kozyk, Marko, Jacobs, Matthew R, White, David   +3 more
core   +1 more source

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

, 2022
AIMS: Genetic and pharmacological inhibition of mitochondrial fission induced by acute myocardial ischaemia/reperfusion injury (IRI) has been shown to reduce myocardial infarct size.
Hernandez-Resendiz, S, Chinda, K, Riquelme, JA, Hausenloy, DJ, Yap, EP, Lees, JG, Samangouei, P, Lim, SY, Kriston-Vizi, J, Costa, JRSD, Rosdah, AA, Crespo-Avilan, GE, Kalkhoran, SB, Ketteler, R, Yellon, DM, Ling, NXY, Holien, JK   +16 more
core   +1 more source

Characterization of NAT2 Using Long‐Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies

Clinical Pharmacology &Therapeutics, EarlyView.
The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John, Erin C. Boone, Byunggil Yoo, Laura B. Ramsey, Andrea Gaedigk   +4 more
wiley   +1 more source

Possible Therapeutic Options for Complex Regional Pain Syndrome

Biomedicines, 2021
Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma.
Myeounghoon Cha, Kyung Hee Lee, Minjee Kwon, Bae Hwan Lee   +3 more
doaj   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response

Antioxidants, 2023
A major hallmark of aging-associated diseases is the inability to evoke cellular defense responses. Transcriptional protein Nrf2 (nuclear factor erythroid-derived 2-related factor) plays a pivotal role in the oxidative stress response, cellular ...
Bhavana Chhunchha, Eri Kubo, Ronald R. Krueger, Dhirendra P. Singh   +3 more
doaj   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Hydralazine Induced ANCA Vasculitis

Hydralazine is a vasodilator commonly used for hypertension. Hydrazine is commonly used in patients who can not tolerate ACEs and ARBs, resistant hypertension, and during pregnancy.
Huang, Justin, Khair, Hani, Sabbineni, Yasasvi, Reddy, Sumanth   +3 more
core   +3 more sources