Results 41 to 50 of about 12,705 (162)

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Sequential carbonyl derivatives and hydrazone adduct formation on myeloperoxidase contribute to development of ANCA vasculitis

The Journal of Clinical Investigation
Drug-induced autoimmune diseases are increasingly recognized, although mechanistic insight into disease causation is lacking. Hydralazine exposure has been linked to autoimmune diseases, including antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Gang Xi, Elizabeth A. Mclnnis, Olivier Lardinois, Peiqi Hu, John S. Poulton, Meghan E. Free, Dhruti P. Chen, Evan M. Zeitler, Eveline Y. Wu, Nicole M. Orzechowski, Vimal K. Derebail, J. Charles Jennette, Ronald J. Falk   +12 more
doaj   +1 more source

Hydralazine Induced Lupus Syndrome Presenting with Recurrent Pericardial Effusion and a Negative Antinuclear Antibody

Case Reports in Rheumatology, 2017
Drug induced lupus erythematosus (DIL or DILE) is an autoimmune disorder caused by chronic use of certain drugs. We report a unique case of hydralazine induced lupus syndrome (HILS) with a negative antinuclear antibody in a female patient who was on ...
Praneet Iyer, Ahmed Dirweesh, Ritika Zijoo   +2 more
doaj   +1 more source

DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Down regulation of genes coding for nucleoside transporters and drug metabolism responsible for uptake and metabolic activation of the nucleoside gemcitabine is related with acquired tumor resistance against this agent.
Myrna Candelaria, Erick de la Cruz-Hernandez, Lucia Taja-Chayeb, Enrique Perez-Cardenas, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Alma Chavez-Blanco, Ernesto Soto-Reyes, Guadalupe Dominguez, Jaenai E Trujillo, Jose Diaz-Chavez, Alfonso Duenas-Gonzalez   +11 more
doaj   +1 more source

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt‐1 in women with new onset hypertension in pregnancy

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 8, Page 1515-1522, August 2026.
In pregnant women with new‐onset hypertension starting antihypertensives, some achieve tight BP control within a week (Group 1‐blue line), while others respond slower (Group 2‐red line). Group 1 showed higher Log10PLGF levels, but Log10sFlt‐1 did not differ between groups. Over time, Log10PLGF declined in both groups, while Log10sFlt‐1 remained stable.
Edward Tyrell, Katherine G. Y. Lau, Martyna Bednorz, Kypros H. Nicolaides, Nikos A. Kametas   +4 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, Volume 604, Issue 16, Page 6659-6674, 15 August 2026.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells

Biology, 2020
Background: Hepatic stellate cell (HSC) activation is essential for the development of liver fibrosis. Epigenetic machinery, such as DNA methylation, is largely involved in the regulation of gene expression during HSC activation.
Kiyoshi Asada, Kosuke Kaji, Shinya Sato, Kenichiro Seki, Naotaka Shimozato, Hideto Kawaratani, Hiroaki Takaya, Yasuhiko Sawada, Keisuke Nakanishi, Masanori Furukawa, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Ryuichi Noguchi, Takemi Akahane, Hitoshi Yoshiji   +15 more
doaj   +1 more source

Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials

Hypertension in Pregnancy, 2022
Objectives This network meta-analysis aimed to compare the efficacy and safety of intravenous (IV) hydralazine, oral nifedipine, and IV labetalol with different dosage regimens in the treatment of severe hypertension during pregnancy.
Hui-Zhen Wu, Yuan Cheng, Ding Yu, Ji-Bin Li, Yun-Fa Jiang, Zhong-Ning Zhu   +5 more
doaj   +1 more source

Autoimmune Disease Risk With GLP‐1RA, DPP‐4i, and SGLT2i Treatment in Patients With Diabetes

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective Dipeptidyl peptidase‐4 inhibitors (DPP‐4i), glucagon‐like peptide‐1 receptor agonists (GLP‐1RA), and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are widely used for type 2 diabetes, yet their comparative immunologic safety is uncertain.
Arjun Mahajan, David W. Bates, Alessandro Doria, Dinah Foer, Avery H. LaChance, Jeffrey A. Sparks   +5 more
wiley   +1 more source

Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary–renal syndrome: a case report

Journal of Medical Case Reports, 2020
Background Hydralazine is a common vasodilator which has been used for the treatment of hypertension and heart failure. Hydralazine can induce antineutrophil cytoplasmic antibody-associated vasculitis due to its auto-immunogenic capability and one of the
Ahmad Al-Abdouh, Abdul Muhaymin Siyal, Hanan Seid, Ammer Bekele, Pablo Garcia   +4 more
doaj   +1 more source