Influence of Sacubitril/Valsartan (LCZ696) on 30-day readmission after heart failure hospitalization [PDF]
, 2016 Background: Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization. Objectives: This study sought to determine if treatment with sacubitril/valsartan (LCZ696) reduces rates ...
Claggett, Brian L. +11 more
core +2 more sources
Possible Therapeutic Options for Complex Regional Pain Syndrome
Biomedicines, 2021 Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma.
Myeounghoon Cha +3 more
doaj +1 more source
Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies [PDF]
, 2016 Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are
Carlson, MC +4 more
core +1 more source
Floating tablets of hydralazine hydrochloride: optimization and evaluation
Brazilian Journal of Pharmaceutical Sciences, 2013 Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy.
Kondi Vanitha +2 more
doaj +1 more source
Antioxidants, 2023 A major hallmark of aging-associated diseases is the inability to evoke cellular defense responses. Transcriptional protein Nrf2 (nuclear factor erythroid-derived 2-related factor) plays a pivotal role in the oxidative stress response, cellular ...
Bhavana Chhunchha +3 more
doaj +1 more source
Increased baseline ECG R-R dispersion predicts improvement in systolic function after atrial fibrillation ablation. [PDF]
, 2019 BackgroundAtrial fibrillation (AF) is associated with left ventricular (LV) systolic dysfunction which may improve after AF ablation. We hypothesised that increased ventricular irregularity, as measured by R-R dispersion on the baseline ECG, would ...
Buch, Eric +7 more
core +1 more source
Hydralazine and Enzalutamide: Synergistic Partners against Prostate Cancer
Biomedicines, 2021 Advanced prostate cancers frequently develop resistance to androgen-deprivation therapy with serious implications for patient survival. Considering their importance in this type of neoplasia, epigenetic modifications have drawn attention as alternative ...
Nair Lopes +6 more
doaj +1 more source
Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad +9 more
wiley +1 more source
Hydralazine inhibits ventricular tachyarrhythmias in an acquired long QT rabbit model
Journal of Arrhythmia, 2014 Background: Some cardioactive vasodilating agents inhibit ventricular tachyarrhythmias (VT) associated with acquired long QT syndrome (LQT). We tested whether a vasodilator without direct cardiac effect can eliminate abnormal repolarization-related VT ...
Kenta Tsutsui, MD +4 more
doaj +1 more source
Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury [PDF]
, 2010 Background The highly reactive aldehyde acrolein is a very potent endogenous toxin with a long half-life. Acrolein is produced within cells after insult, and is a central player in slow and progressive "secondary injury" cascades.
Youngnam Cho +2 more
core +2 more sources