Results 31 to 40 of about 15,167 (190)

Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines

Cancer Cell International, 2006
Background Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineoplastic activity in a variety of ...
Candelaria Myrna, Gonzalez-Fierro Aurora, Trejo-Becerril Catalina, Taja-Chayeb Lucia, Segura-Pacheco Blanca, Rangel-Lopez Edgar, Carrasco-Legleu Claudia, Perez-Cardenas Enrique, Perez-Plasencia Carlos, Chavez-Blanco Alma, Cabrera Gustavo, Duenas-Gonzalez Alfonso   +11 more
doaj   +1 more source

Hydralazine Associated With Reduced Therapeutic Phlebotomy Frequency in a Nationwide Cohort Study: Real-World Effectiveness for Drug Repurposing

Frontiers in Pharmacology, 2022
Background: Therapeutic phlebotomy, known as scheduled bloodletting, has been the main method for managing erythrocytosis symptoms and thrombocytosis-associated complications in various blood disorders.
Wei-Zhi Lin, Chi-Hsiang Chung, Chi-Hsiang Chung, Chi-Hsiang Chung, Chia-Yang Shaiu, Chia-Yang Shaiu, Bing-Heng Yang, Bing-Heng Yang, Wu-Chien Chien, Wu-Chien Chien, Wu-Chien Chien, Wu-Chien Chien   +11 more
doaj   +1 more source

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

Frontiers in Neurology, 2019
Although the pathogenic mechanisms of Parkinson's disease (PD) remain unclear, ample empirical evidence suggests that oxidative stress is involved in the pathogenesis of this disease.
Xingfang Guo, Chao Han, Kai Ma, Yun Xia, Fang Wan, Sijia Yin, Liang Kou, Yadi Sun, Jiawei Wu, Junjie Hu, Jinsha Huang, Nian Xiong, Tao Wang   +12 more
doaj   +1 more source

The Protective Effect of Hydralazine against Hydrogen Peroxide (H2O2)-Induced Oxidative Damage in C6 Glial Cell Line

Türk Fen ve Sağlık Dergisi, 2021
Purpose: Recent studies have shown that hydralazine has positive effects on nervous system. However, its effect on hydrogen peroxide-induced oxidative damage in glial cells is still unclear.
Ahmet Şevki Taşkıran, Mustafa Ergül
doaj  

Effect of the cholinergic system of the lateral periaqueductal gray (lPAG) on blood pressure and heart rate in normal and hydralazine hypotensive rats [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Due to the presence of the cholinergic system in the lateral periaqueductal gray (lPAG) column, the cardiovascular effects of Acetylcholine (ACH) and its receptors in normotensive and hydralazine (HYD) hypotensive rats in this area were ...
Atiyeh Ghorbani, Reza Mohebbati, Alireza Rahimi, Vida Alikhani, Mohammad Naser Shafei   +4 more
doaj   +1 more source

COMPARISON OF HYDRALAZINE AND LABETALOL IN THE MANAGEMENT OF HYPERTENSIVE DISORDERS OF PREGNANCY

Pakistan Armed Forces Medical Journal, 2022
Objective: To compare the efficacy of intravenous hydralazine and intravenous labetalol for acutely lowering blood pressure in pregnancy. Study Design: Randomized control trial (RCT).
Humaira Osman Jaffery, Kausar Tasleem Bangash   +1 more
doaj   +2 more sources

Hydralazine-induced constrictive pericarditis

, 1996
A 59-year-old man was diagnosed as having constrictive pericarditis 17 months after a typical hydralazine-induced autoimmune syndrome, This late complication of hydralazine has been reported only once.
Gans, ROB; id_orcid, Franssen, CFC; id_orcid, ElGamal, MIH, Hoorntje, SJ   +3 more
core   +2 more sources

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Nature Communications, 2017
Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C.
Esmaeil Dehghan, Yiqiang Zhang, Bahar Saremi, Sivaramakrishna Yadavali, Amirmansoor Hakimi, Maryam Dehghani, Mohammad Goodarzi, Xiaoqin Tu, Scott Robertson, Rueyling Lin, Asish Chudhuri, Hamid Mirzaei   +11 more
doaj   +1 more source

Drug-induced vasculitis

Indian Journal of Rheumatology, 2019
Vascular injury due to drugs is recognized as a distinct entity under the Chapel Hill Consensus Conference 2012 definitions for vasculitis. Drug-induced vasculitis (DIV) may affect various types of vessels.
Durga Prasanna Misra, Pallavi Patro, Aman Sharma   +2 more
doaj   +1 more source

Inhibition of α2-adrenoceptor is renoprotective in 5/6 nephrectomy-induced chronic kidney injury rats

Journal of Pharmacological Sciences, 2021
In the present study, we investigated the renoprotective effects of long-term treatment with yohimbine, an α2-adrenoceptor inhibitor, in a 5/6 nephrectomy-induced chronic kidney disease (CKD) rat model.
Kohei Hayashi, Takaomi Shimokawa, Masayo Yamagata, Kozo Yoneda   +3 more
doaj   +1 more source