A study of redox properties of hydralazine hydrochloride, an antihypertensive drug [PDF]
Journal of Saudi Chemical Society, 2010 Hydralazine hydrochloride itself is a reducing agent and its redox properties like other reducing agents vary as the oxidizing agent and applied conditions vary. The redox properties of hydralazine were studied by spectrophotometric method.
Saima Imad +2 more
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ANA-Negative Hydralazine-Induced Pericardial Effusion [PDF]
Case Reports in Medicine, 2017 This case describes a patient with pericardial effusion as a phenomenon of the drug-induced lupus erythematosus (DILE) syndrome due to hydralazine. The relevance of this case report lies in the fact that although hydralazine has been a known causative ...
Vicken Zeitjian, Azar Mehdizadeh
doaj +2 more sources
Impact of N-Acetylation on DNA Damage and Oxidative Stress Responses in Mammalian Cells and Human Hepatocytes Treated with Hydralazine [PDF]
BiomoleculesHydralazine is widely used to treat hypertension during pregnancy and has epigenetic effects in cancer therapy. Cryoplatable human hepatocytes showed concentration-dependent increase in DNA damage response (linear trend p = 0.0069) following 24 h ...
Mariam R. Habil +7 more
doaj +2 more sources
Hydralazine Attenuates Lipopolysaccharide-Induced Murine Myocardial Dysfunction by Inhibition of Semicarbazide-Sensitive Amine Oxidase [PDF]
AntioxidantsSepsis-induced myocardial dysfunction (SIMD) is a fatal complication with limited therapeutic options. Semicarbazide-sensitive amine oxidase (SSAO) contributes to oxidative stress and leukocyte recruitment, yet its role in SIMD remains unexplored.
Zejian Kuang +5 more
doaj +2 more sources
Floating tablets of hydralazine hydrochloride: optimization and evaluation [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2013 Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy.
Kondi Vanitha +2 more
doaj +2 more sources
Anti-proliferative Effects of Hydralazine on K562 Cell Line (CML)
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2017 Introduction: Cancer is the second leading cause of death in the world and among the types of cancer, leukemia is one of the deadliest. Chronic myeloid leukemia (CML) is the best known types of leukemia. Hydralazine is in the cardiovascular medical group,
Sonya Dadakhani +2 more
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Acute Low-Dose Hydralazine-Induced Lupus Pneumonitis [PDF]
Case Reports in Pulmonology, 2017 A 35-year-old female was started on hydralazine 10 mg orally three times a day for treatment of postpartum hypertension. Three months later, after multiple unsuccessful courses of prednisone and antibiotics for presumed pneumonia and asthma exacerbations,
Sarah K. Holman +3 more
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Clinical Function Assignment of NAT2 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel. [PDF]
Clin Pharmacol TherNAT2 encodes arylamine N‐acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 ...
Tibben BM +10 more
europepmc +2 more sources
Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma
Scientific Reports, 2021 This study investigates the use of hydralazine to enhance ultrasound hyperthermia for the treatment of hepatocellular carcinoma (HCC) by minimizing flow-mediated heat loss from the tumor.
Mrigendra B. Karmacharya +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 BackgroundMaternal obesity is a risk factor for chronic kidney disease (CKD) in offspring, underpinning the theory of the developmental origins of health and disease.
Benjamin P. Larkin +9 more
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