Results 11 to 20 of about 31,338 (264)

Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary–renal syndrome: a case report

Journal of Medical Case Reports, 2020
Background Hydralazine is a common vasodilator which has been used for the treatment of hypertension and heart failure. Hydralazine can induce antineutrophil cytoplasmic antibody-associated vasculitis due to its auto-immunogenic capability and one of the
Ahmad Al-Abdouh, Abdul Muhaymin Siyal, Hanan Seid, Ammer Bekele, Pablo Garcia   +4 more
doaj   +2 more sources

Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials

Hypertension in Pregnancy, 2022
Objectives This network meta-analysis aimed to compare the efficacy and safety of intravenous (IV) hydralazine, oral nifedipine, and IV labetalol with different dosage regimens in the treatment of severe hypertension during pregnancy.
Hui-Zhen Wu, Yuan Cheng, Ding Yu, Ji-Bin Li, Yun-Fa Jiang, Zhong-Ning Zhu   +5 more
doaj   +2 more sources

Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Nature Communications, 2019
Hydralazine is a drug used in the treatment of heart failure and cancer, and it has recently been shown to promote lifespan in C. elegans. Here, the authors elucidate the mechanism of action of hydralazine, and show that it targets PKA to promote ...
Esmaeil Dehghan, Mohammad Goodarzi, Bahar Saremi, Rueyling Lin, Hamid Mirzaei   +4 more
doaj   +2 more sources

ANA-Negative Hydralazine-Induced Pericardial Effusion

Case Reports in Medicine, 2017
This case describes a patient with pericardial effusion as a phenomenon of the drug-induced lupus erythematosus (DILE) syndrome due to hydralazine. The relevance of this case report lies in the fact that although hydralazine has been a known causative ...
Vicken Zeitjian, Azar Mehdizadeh
doaj   +2 more sources

Sequential carbonyl derivatives and hydrazone adduct formation on myeloperoxidase contribute to development of ANCA vasculitis [PDF]

The Journal of Clinical Investigation
Drug-induced autoimmune diseases are increasingly recognized, although mechanistic insight into disease causation is lacking. Hydralazine exposure has been linked to autoimmune diseases, including antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Gang Xi, Elizabeth A. Mclnnis, Olivier Lardinois, Peiqi Hu, John S. Poulton, Meghan E. Free, Dhruti P. Chen, Evan M. Zeitler, Eveline Y. Wu, Nicole M. Orzechowski, Vimal K. Derebail, J. Charles Jennette, Ronald J. Falk   +12 more
doaj   +2 more sources

Hydralazine Induced Lupus Syndrome Presenting with Recurrent Pericardial Effusion and a Negative Antinuclear Antibody

Case Reports in Rheumatology, 2017
Drug induced lupus erythematosus (DIL or DILE) is an autoimmune disorder caused by chronic use of certain drugs. We report a unique case of hydralazine induced lupus syndrome (HILS) with a negative antinuclear antibody in a female patient who was on ...
Praneet Iyer, Ahmed Dirweesh, Ritika Zijoo   +2 more
doaj   +2 more sources

Haptenization as the missing link between vasculitis and myeloperoxidase [PDF]

The Journal of Clinical Investigation
A wide variety of medications can induce adverse immune events and autoimmune responses such as vasculitis. Mechanistically, small molecule drugs known as haptens bind and modify endogenous proteins, triggering such immune reactions. In this issue of the
Laura Santambrogio
doaj   +2 more sources

Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review [PDF]

Case Reports in Cardiology
Hydralazine, a commonly used arterial vasodilator for managing congestive heart failure and hypertension, is known to be associated with drug-induced lupus and, less frequently, antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Drug-
Ahmed Sami Hammami, Osejie Oriaifo, Sinda Hidri, Sukhvir Singh, Husam El Sharu, Joshua Peltz, Soroush Nomigolzar, Kunjan Udani   +7 more
doaj   +2 more sources

Double Trouble: Drug-Induced Autoimmune Hepatitis (AIH)-Primary Biliary Cholangitis (PBC) Overlap Syndrome Triggered by Hydralazine. [PDF]

Cureus
Chaudhuri U, Forrest JR, Sastry K, Reagans R, Agrawal S.   +4 more
europepmc   +3 more sources

Drug‐Induced Renal Vasculitis: Etiology, Pathogenesis, Clinical Manifestations, and Therapeutic Approaches—A Narrative Review [PDF]

Health Science Reports
Background and Aims Drug‐induced renal vasculitis arises from various medications that cause immunological dysregulation or direct vascular damage, leading to inflammation and thrombosis.
Hashim Mohamed Siraj, Masab Ali, Sampda Sanjaykumar Sharma, Afreen Begum, Muhammad Husnain Ahmad, Muhammad Hassan, Roba Kamaleldin Moustafa Kamel Aref Elsayed, Muhammad Hamza Tahir   +7 more
doaj   +2 more sources