Results 21 to 30 of about 22,486 (258)

Drug-Induced Renal Vasculitis: Etiology, Pathogenesis, Clinical Manifestations, and Therapeutic Approaches-A Narrative Review. [PDF]

Health Sci Rep
Background and Aims Drug‐induced renal vasculitis arises from various medications that cause immunological dysregulation or direct vascular damage, leading to inflammation and thrombosis.
Mohamed Siraj H, Ali M, Sharma SS, Begum A, Ahmad MH, Muhammad H, Aref Elsayed RKMK, Tahir MH.   +7 more
europepmc   +2 more sources

Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines

Cancer Cell International, 2006
Background Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineoplastic activity in a variety of ...
Candelaria Myrna, Gonzalez-Fierro Aurora, Trejo-Becerril Catalina, Taja-Chayeb Lucia, Segura-Pacheco Blanca, Rangel-Lopez Edgar, Carrasco-Legleu Claudia, Perez-Cardenas Enrique, Perez-Plasencia Carlos, Chavez-Blanco Alma, Cabrera Gustavo, Duenas-Gonzalez Alfonso   +11 more
doaj   +1 more source

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Nature Communications, 2017
Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C.
Esmaeil Dehghan, Yiqiang Zhang, Bahar Saremi, Sivaramakrishna Yadavali, Amirmansoor Hakimi, Maryam Dehghani, Mohammad Goodarzi, Xiaoqin Tu, Scott Robertson, Rueyling Lin, Asish Chudhuri, Hamid Mirzaei   +11 more
doaj   +1 more source

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

Frontiers in Neurology, 2019
Although the pathogenic mechanisms of Parkinson's disease (PD) remain unclear, ample empirical evidence suggests that oxidative stress is involved in the pathogenesis of this disease.
Xingfang Guo, Chao Han, Kai Ma, Yun Xia, Fang Wan, Sijia Yin, Liang Kou, Yadi Sun, Jiawei Wu, Junjie Hu, Jinsha Huang, Nian Xiong, Tao Wang   +12 more
doaj   +1 more source

Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.

PLoS ONE, 2021
BackgroundMaternal high fat diet (HFD) promotes chronic kidney disease (CKD) in offspring. This is in accordance with the theory of fetal programming, which suggests adverse conditions occurring in utero predispose offspring to chronic conditions later ...
Benjamin P Larkin, Sonia Saad, Sarah J Glastras, Long T Nguyen, Miao Hou, Hui Chen, Rosy Wang, Carol A Pollock   +7 more
doaj   +1 more source

ANA-Negative Hydralazine-Induced Pericardial Effusion

Case Reports in Medicine, 2017
This case describes a patient with pericardial effusion as a phenomenon of the drug-induced lupus erythematosus (DILE) syndrome due to hydralazine. The relevance of this case report lies in the fact that although hydralazine has been a known causative ...
Vicken Zeitjian, Azar Mehdizadeh
doaj   +1 more source

Variations in Arterial Blood Pressure after Kidney Transplantation [PDF]

, 1973
The course of hypertension within the first 2 months after kidney transplantation was correlated with renal function, plasma renin activity (PRA), and the daily maintenance dose of prednisone in 18 homograft recipients.
CORMAN, JACQUES L, HALGRIMSON, CHARLES G, KATZ, FRED H, LANOIS, BERNARD, PINNGGERA, WULF, POPOVTZER, MORDECAI M, ROBINETTE, JOHN, STARZL, THOMAS E   +7 more
core   +1 more source

Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome [PDF]

, 2018
Hydralazine, a vasodilator, is commonly used as an adjunctive treatment for moderate to severe hypertension, heart failure and hypertensive emergencies in pregnancy. Hydralazine-induced lupus was first described in 1953. Clinical presentation ranges from
Aeddula, Narothama Reddy, Ansari, Asif, Juran, Peter J., Pathireddy, Samata   +3 more
core   +1 more source

Studies on the cardiovascular actions of hydralazine.

Acta Médica Portuguesa, 1979
In conscious normotensive rabbits, the intravenous administration of hydralazine (0.3 mg/Kg) induced a significant decrease of mean arterial blood pressure (MBP) (p 0.05) and did not modify the tachycardia.
Virgílio Durão, Assunção Elvas
doaj   +1 more source

Liver rejection and its differentiation from other causes of graft dysfunction. [PDF]

, 1985
Numerous causes can lead to hepatic dysfunction following orthotopic liver transplantation. The most common cause is rejection, which is usually nonpreventable. The clinical presentation, time of onset, and even treatment are variable. Other causes, such
Esquivel, CO, Gordon, RD, Iwatsuki, S, Jaffe, R, Shaw, BW, Starzl, TE   +5 more
core   +1 more source