Results 21 to 30 of about 31,338 (264)

Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2023
Background Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction ...
Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, D. Lefer   +12 more
semanticscholar   +1 more source

A Delayed Adverse Reaction: Hydralazine-Induced Lupus After Years of Use. [PDF]

Cureus
Paudel S, Acharya A, Poudel S, Rijal SS.
europepmc   +3 more sources

Mechanistic Investigation of the Time-Dependent Aldehyde Oxidase Inhibitor Hydralazine

Drug Metabolism And Disposition, 2023
The anti-hypertensive agent hydralazine is a time-dependent inhibitor of the cytosolic drug-metabolizing enzyme aldehyde oxidase (AO). Glutathione (GSH) was found to suppress the inhibition of AO by hydralazine in multiple enzyme sources (human liver and
J. P. Barnes, Shaoyun M Yang, Taylor S Thompson, Caithlyne M. Guevarra, Shaniya S Pleasant, Tri Q. Do, R. Crouch   +6 more
semanticscholar   +1 more source

Comparing Intravenous Labetalol and Intravenous Hydralazine for Managing Severe Gestational Hypertension

Cureus, 2023
Background Hypertensive disorders of pregnancy are the leading causes of both maternal morbidity and maternal mortality. Hypertensive disorders are acute obstetric emergencies, which refer to various life-threatening medical challenges known to develop ...
Eustace Ehikioya, O. Okobi, Maame Akosua E Beeko, Rafia Abanga, Namtor Nicole I Abah, Lilian Briggs, Patience N Nwimo, P. Beeko, Onyinyechukwu B Nwachukwu, Caroline C Okoroafor   +9 more
semanticscholar   +1 more source

Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice

International Journal of Molecular Sciences, 2023
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an ...
Yutang Wang, Owen Sargisson, Dinh Tam Nguyen, Ketura Parker, Stephan J. R. Pyke, Ahmed Alramahi, Liam Thihlum, Yan Fang, Morgan E. Wallace, Stuart P. Berzins, E. Oqueli, D. Magliano, J. Golledge   +12 more
semanticscholar   +1 more source

Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma

Scientific Reports, 2021
This study investigates the use of hydralazine to enhance ultrasound hyperthermia for the treatment of hepatocellular carcinoma (HCC) by minimizing flow-mediated heat loss from the tumor.
Mrigendra B. Karmacharya, Laith R. Sultan, Stephen J. Hunt, Chandra M. Sehgal   +3 more
doaj   +1 more source

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

Cardiovascular Research, 2021
Aims Genetic and pharmacological inhibition of mitochondrial fission induced by acute myocardial ischaemia/reperfusion injury (IRI) has been shown to reduce myocardial infarct size.
S. Kalkhoran, J. Kriston-Vizi, S. Hernandez-Resendiz, G. Crespo-Avilan, A. A. Rosdah, J. Lees, Joana Rodrigues Simoes Da Costa, Naomi X. Y. Ling, J. Holien, P. Samangouei, K. Chinda, En Ping Yap, Jaime A Riquelme, R. Ketteler, D. Yellon, Shiang Y. Lim, D. Hausenloy   +16 more
semanticscholar   +1 more source

Potential Impacts of Hydralazine as a Novel Antioxidant on Cardiovascular and Renal Disease—Beyond Vasodilation and Blood Pressure Lowering

Antioxidants, 2022
Hydralazine is a traditional antihypertensive drug that was developed several decades ago. Its most well-known effect is blood pressure lowering by arterial vasodilation.
Ting-Ting Chang, Jaw-Wen Chen
doaj   +1 more source

Eco-friendly estimation of isosorbide dinitrate and hydralazine hydrochloride using Green Analytical Quality by Design-based UPLC Method

RSC Advances, 2021
Isosorbide dinitrate (ISD) and hydralazine hydrochloride (HDZ) are critical drugs for the treatment of heart failure. Currently, no available analytical method for the determination of ISD and HDZ exists as per the literature that combines UPLC and Green
Hemanth Kumar Chanduluru, Abimanyu Sugumaran   +1 more
semanticscholar   +1 more source

A Modified MTS Proliferation Assay for Suspended Cells to Avoid the Interference by Hydralazine and β-Mercaptoethanol

Assay and drug development technologies, 2021
The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay is one of the most commonly used tests of cell proliferation.
Yutang Wang, Dinh Tam Nguyen, Guang Yang, Jack Anesi, Jason Kelly, Z. Chai, F. Ahmady, F. Charchar, J. Golledge   +8 more
semanticscholar   +1 more source