Results 31 to 40 of about 22,486 (258)

DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells. [PDF]

open access: yesPLoS ONE, 2012
BACKGROUND: Down regulation of genes coding for nucleoside transporters and drug metabolism responsible for uptake and metabolic activation of the nucleoside gemcitabine is related with acquired tumor resistance against this agent.
Myrna Candelaria   +11 more
doaj   +1 more source

Hydralazine-induced vasculitis presenting with ocular manifestations

open access: yesAmerican Journal of Ophthalmology Case Reports, 2022
Purpose: The objective of the study is to report a case of ocular manifestations in a patient with hydralazine-induced vasculitis. Observations: An 88-year-old female was admitted for lower gastrointestinal bleeding.
Vivian S. Hawn   +3 more
doaj  

Floating tablets of hydralazine hydrochloride: optimization and evaluation

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2013
Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy.
Kondi Vanitha   +2 more
doaj   +1 more source

Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response

open access: yesAntioxidants, 2023
A major hallmark of aging-associated diseases is the inability to evoke cellular defense responses. Transcriptional protein Nrf2 (nuclear factor erythroid-derived 2-related factor) plays a pivotal role in the oxidative stress response, cellular ...
Bhavana Chhunchha   +3 more
doaj   +1 more source

Hydralazine and Enzalutamide: Synergistic Partners against Prostate Cancer

open access: yesBiomedicines, 2021
Advanced prostate cancers frequently develop resistance to androgen-deprivation therapy with serious implications for patient survival. Considering their importance in this type of neoplasia, epigenetic modifications have drawn attention as alternative ...
Nair Lopes   +6 more
doaj   +1 more source

His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]

open access: yes, 1988
The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M.   +3 more
core   +1 more source

Possible Therapeutic Options for Complex Regional Pain Syndrome

open access: yesBiomedicines, 2021
Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma.
Myeounghoon Cha   +3 more
doaj   +1 more source

The introduction of a ward-based medical team system within a General and Emergency Medical Directorate [PDF]

open access: yes, 2003
BACKGROUND: The evidence base for improving reproductive health continues to grow. However, concerns remain that the translation of this evidence into appropriate policies is partial and slow.
Glynn, M, Lewin, S, Meyer, J, Reeves, S
core   +6 more sources

How to assess and manage hypertension during and after pregnancy. [PDF]

open access: yes, 2013
Hypertensive disorders of pregnancy are increasingly important complications of which clinicians should have an up-to-date knowledge to facilitate prompt recognition, diagnosis and management.
Freeman, Dilys   +3 more
core   +1 more source

DRUG THERAPY PROBLEMS DURING PALLIATIVE ONCOLOGY CARE

open access: yesТазовая хирургия и онкология, 2015
Introduction. Palliative care for oncological patients requires dealing with multiple disease symptoms and requires multi-drug therapy. The search for wide-spectre drugs which can affect different pathological pathways is a pressing matter.Methods.
A. V. Palekhov, V. M. Danilian
doaj   +1 more source

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