Results 51 to 60 of about 31,338 (264)

Efficacy of nifedipine versus hydralazine in the management of severe hypertension in pregnancy: A randomised controlled trial

Nigerian Postgraduate Medical Journal, 2020
Background: Despite the availability of effective antihypertensive drugs, the quality of evidence regarding the best antihypertensive agent for the treatment of hypertensive emergencies in pregnancy is still poor.
J. Adebayo, J. Nwafor, L. Lawani, C. Esike, A. Olaleye, N. Adiele   +5 more
semanticscholar   +1 more source

An Improved 3-(4,5-Dimethylthiazol-2-yl)-5-(3-Carboxymethoxyphenyl)-2-(4-Sulfophenyl)-2H-Tetrazolium Proliferation Assay to Overcome the Interference of Hydralazine

Assay and drug development technologies, 2020
The MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay is one of the most commonly used assays to assess cell proliferation and cytotoxicity, but is subject to interference by testing compounds ...
Yutang Wang, Dinh Tam Nguyen, Guang Yang, Jack Anesi, Z. Chai, F. Charchar, J. Golledge   +6 more
semanticscholar   +1 more source

Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors.

ACS Nano, 2019
Desmoplastic tumors are normally resistant to nanoparticle-based chemotherapy due to dense stroma and limited particle permeability inside the tumor. Herein, we reported that hydralazine (HDZ)-an antihypertension vasodilator-would dramatically promote ...
Yanzuo Chen, Wantong Song, Limei Shen, Nasha Qiu, Mengying Hu, Yun Liu, Qi Liu, Leaf Huang   +7 more
semanticscholar   +1 more source

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm [PDF]

, 2016
Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of ...
Abozguia, AIRE Study Group, Alexander, Alexander, Alexander, Alexander, Ashrafian, Bailey, Bailey, Basu, Beadle, Braunwald, Brown, Burgoyne, Chaitman, Chatterjee, Chung, CIBIS-II Study Group, Cleland, Clerc, Cohn, Cohn, Cohn, CONSENSUS Trial Study Group, Conway, Cook, Dai, Digitalis Investigation Group, Doenst, Dzau, Dzau, Faris, Flather, Follath, Foster, Fox, Fox, Fragasso, Furberg, Gheorghiade, Gladwin, Goffart, Granger, Greenberg, Guazzi, Guazzi, Heymans, Hobbs, Holubarsch, Horowitz, Horowitz, Kantor, Kapil, Kato, Kennedy, Kennedy, Kostis, Larsen, Lee, Lopaschuk, Luiken, Lundberg, Maher, Maier, Mancini, Mann, Mann, Massie, Mccormack, Mcdowell, Mcmurray, Mcmurray, Merit-Hf Study Group, Munzel, Munzel, Neglia, Neubauer, Ormerod, Packer, Packer, Paul, Pawson, Pfeffer, Pfeffer, Pitt, Pitt, Rathore, Rauchhaus, Redfield, Rona, Sack, Sarraf, Schmidt-Schweda, Schrauwen, Schwarz, Shah, Shah, Siddiqi, Singh, SOLVD Investigators, Stanley, Swedberg, Szwed, Taylor, Teerlink, Tilemann, Torre-Amione, Totzeck, Turcani, Unger, Van Der Vusse, Van Faassen, Vardeny, Webb, Yin, Yusuf, Zamani, Zannad, Zannad, Zhang   +119 more
core   +1 more source

Translating research into policy and practice in developing countries: a case study of magnesium sulphate for pre-eclampsia. [PDF]

, 2005
BACKGROUND: The evidence base for improving reproductive health continues to grow. However, concerns remain that the translation of this evidence into appropriate policies is partial and slow.
Aaserud, Morten, Dahlgren, Astrid T, Duley, Lelia, Innvaer, Simon, Lewin, Simon, Oxman, Andrew D, Paulsen, Elizabeth J, Trommald, Mari, Zwarenstein, Merrick   +8 more
core   +4 more sources

Epigenetic treatment of solid tumours. A review of clinical trials [PDF]

, 2015
Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observe in cutaneous lymphomas represents a proof of principle that similar results may be obtained in solid tumours. Several agents that interfere
CODACCI PISANELLI, Giovanni, DE MARINIS, ELISABETTA, NERVI, Clara   +2 more
core   +2 more sources

Floating tablets of hydralazine hydrochloride: optimization and evaluation

Brazilian Journal of Pharmaceutical Sciences, 2013
Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy.
Kondi Vanitha, Mohan Varma, Alluri Ramesh   +2 more
doaj   +1 more source

Studies on the cardiovascular actions of hydralazine.

Acta Médica Portuguesa, 1979
In conscious normotensive rabbits, the intravenous administration of hydralazine (0.3 mg/Kg) induced a significant decrease of mean arterial blood pressure (MBP) (p 0.05) and did not modify the tachycardia.
Virgílio Durão, Assunção Elvas
doaj   +1 more source

DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Down regulation of genes coding for nucleoside transporters and drug metabolism responsible for uptake and metabolic activation of the nucleoside gemcitabine is related with acquired tumor resistance against this agent.
Myrna Candelaria, Erick de la Cruz-Hernandez, Lucia Taja-Chayeb, Enrique Perez-Cardenas, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Alma Chavez-Blanco, Ernesto Soto-Reyes, Guadalupe Dominguez, Jaenai E Trujillo, Jose Diaz-Chavez, Alfonso Duenas-Gonzalez   +11 more
doaj   +1 more source

Possible Therapeutic Options for Complex Regional Pain Syndrome

Biomedicines, 2021
Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma.
Myeounghoon Cha, Kyung Hee Lee, Minjee Kwon, Bae Hwan Lee   +3 more
doaj   +1 more source