Results 71 to 80 of about 21,060 (203)

Irreversible renal damage after transient renin-angiotensin system stimulation:involvement of an AT1-receptor mediated immune response [PDF]

, 2013
Transient activation of the renin-angiotensin system (RAS) induces irreversible renal damage causing sustained elevation in blood pressure (BP) in Cyp1a1-Ren2 transgenic rats. In our current study we hypothesized that activation of the AT1-receptor (AT1R)
A Leibowitz, AA Eddy, AJ Brown, B Knier, B Peters, Bart F. J. Heijnen, Ben J. A. Janssen, BFJ Heijnen, C De Miguel, C Nataraj, Carine J. Peutz-Kootstra, Casper G. Schalkwijk, CG Howard, DA Kasal, DE Williams, DG Harrison, DT Denhardt, EC Viel, EL Schiffrin, EL Schiffrin, Gregorio E. Fazzi, H Kvakan, Harry AJ. Struijker-Boudier, Helma van Essen, J Shao, Jan W. Cohen Tervaert, JD Zhang, Jean-Claude Dussaule, Jelly Nelissen, JM Lorenzen, John J. Mullins, JW Cohen Tervaert, K Mori, KD Mitchell, KD Mitchell, M Baumann, M Ruiz-Ortega, ML Graciano, MS Madhur, N Takeichi, P Devarajan, PJ Marvar, R Tamosiuniene, S Fu, S Kantachuvesiri, SA Griffin, SD Crowley, SE Umetsu, SK Bromley, T Barhoumi, T Kato, T Wolak, TJ Guzik, TJ Murphy, Y Nozaki, Y Ozawa, Z Honetschlagerova, Z Huskova, Z Vanourkova   +58 more
core   +4 more sources

Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Nature Communications, 2019
Hydralazine is a drug used in the treatment of heart failure and cancer, and it has recently been shown to promote lifespan in C. elegans. Here, the authors elucidate the mechanism of action of hydralazine, and show that it targets PKA to promote ...
Esmaeil Dehghan, Mohammad Goodarzi, Bahar Saremi, Rueyling Lin, Hamid Mirzaei   +4 more
doaj   +1 more source

DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Down regulation of genes coding for nucleoside transporters and drug metabolism responsible for uptake and metabolic activation of the nucleoside gemcitabine is related with acquired tumor resistance against this agent.
Myrna Candelaria, Erick de la Cruz-Hernandez, Lucia Taja-Chayeb, Enrique Perez-Cardenas, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Alma Chavez-Blanco, Ernesto Soto-Reyes, Guadalupe Dominguez, Jaenai E Trujillo, Jose Diaz-Chavez, Alfonso Duenas-Gonzalez   +11 more
doaj   +1 more source

Modulation of renal oxygenation and perfusion in rat kidney monitored by quantitative diffusion and blood oxygen level dependent magnetic resonance imaging on a clinical 1.5T platform [PDF]

, 2016
ARRIVE Checklist.
David J. Collins, Dow-Mu Koh, James d’Arcy, Jessica K. R. Boult, Martin O. Leach, Matthew R. Orton, Neil P. Jerome, Simon P. Robinson   +7 more
core   +3 more sources

Inventory Management Performance for Lifesaving Maternal and Child Health Medicines in Amhara Regional State, Ethiopia: A Facility‐Based Cross‐Sectional Mixed Method Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Maternal mortality is a major public health issue in Ethiopia, with 412 deaths per 100,000 live births. Pregnancy‐related causes make up 25% of female deaths, highlighting the crisis's seriousness. Improving inventory management could enhance health system performance.
Ayalew Sirbemo Degebo, Gizachew Tilahun
wiley   +1 more source

Hydralazine combined with conventional therapy improved outcomes in severe systolic dysfunction and mitral regurgitation

ESC Heart Failure
Aims Patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF) accompanied by significant mitral regurgitation (MR) had poor outcome. Several vasodilator trials showed neutral results.
Shih‐Hung Hsiao, Chao‐Sheng Hsiao, Jau‐Wen Shiau, Kuan‐Rau Chiou   +3 more
doaj   +1 more source

Impact of N-Acetylation on DNA Damage and Oxidative Stress Responses in Mammalian Cells and Human Hepatocytes Treated with Hydralazine

Biomolecules
Hydralazine is widely used to treat hypertension during pregnancy and has epigenetic effects in cancer therapy. Cryoplatable human hepatocytes showed concentration-dependent increase in DNA damage response (linear trend p = 0.0069) following 24 h ...
Mariam R. Habil, Makayla A. Stephens, Alexandra A. Cass, Elise M. Mittlestat, Darbie Kwon, Alexandra Ellison, J. Calvin Kouokam, David W. Hein   +7 more
doaj   +1 more source

A Challenging Twist in Pulmonary Renal Syndrome

Case Reports in Rheumatology, 2014
Case. We report a rare case of hydralazine-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. A 75-year-old African American woman with history of high blood pressure on hydralazine for 3 years presented with acute onset of shortness of ...
Rajaie Namas, Bernard Rubin, Wamidh Adwar, Alireza Meysami   +3 more
doaj   +1 more source

Use of Hydralazine‐Isosorbide Dinitrate Combination in African American and Other Race/Ethnic Group Patients With Heart Failure and Reduced Left Ventricular Ejection Fraction [PDF]

, 2013
Background: Hydralazine‐isosorbide dinitrate (H‐ISDN) therapy is recommended for African American patients with moderate to severe heart failure with reduced ejection fraction (
Bhatt, Deepak L., Butler, Javed, Fonarow, Gregg C., Golwala, Harsh B., Hernandez, Adrian F., Liang, Li, Stavrakis, Stavros, Thadani, Udho, Yancy, Clyde W.   +8 more
core   +1 more source

Hepatotoxicity Associated with Labetalol Use: A Case Report with Systematic Review and Disproportionality Analysis Using FAERS

The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.
Abstract Labetalol is widely prescribed as a first‐line antihypertensive in pregnancy; however, rare but potentially severe idiosyncratic hepatotoxicity has been reported, with a disproportionately strong reporting signal for liver injury relative to other β‐blockers.
Emma D. Hendriksen, Michael Rieder, Elizabeth Urbantke   +2 more
wiley   +1 more source