Results 71 to 80 of about 31,338 (264)

Hydralazine and nitrates in the treatment of heart failure with reduced ejection fraction

ESC Heart Failure, 2019
Hydralazine and nitrate combination was the first treatment that showed improved survival of patients with heart failure with reduced left ventricular ejection fraction (HFREF) in the Vasodilator Heart Failure Trial (V‐HeFT trial) in 1986.
A. Al-Mohammad
semanticscholar   +1 more source

Measurement and management of adult blood pressure in the peri‐operative period: updated guidelines from the Association of Anaesthetists and the British and Irish Hypertension Society

Anaesthesia, EarlyView.
Summary Introduction Maintaining stable blood pressure during surgery is a key responsibility of anaesthetists. Peri‐operative omission and reintroduction of antihypertensive drugs, general anaesthesia, neuraxial and regional techniques can all cause significant fluctuations in blood pressure, particularly in patients with hypertension. Since the first
Terry McCormack, Alex Wickham, Sinéad T. J. McDonagh, Matthew D. Wiles, Luca Faconti, Rachael Brooks, Simon G. Anderson, Andrew Hartle   +7 more
wiley   +1 more source

An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate [PDF]

, 2014
Background and Purpose Combretastatin A-4 3-O-phosphate (CA4P) is in clinical trial as a tumour vascular disrupting agent (VDA) but the cause of blood flow disruption is unclear.
Alblas, Alexander, Bao, Beuge, Boehle, Dark, Dowlati, Fehon, Galbraith, Hamid, Hill, Ito, Kanthou, Kanthou, Ke, Kilkenny, Lunt, Matsui, Mavria, McGown, McGrath, Meel, Moosmang, Murata, Murata, Nathan, Orian-Rousseau, Parkins, Pawson, Pedley, Pettit, Pettit, Prise, Reyes-Aldasoro, Richman, Rikitake, Rodrigues, Rustin, Saito, Sawada, Shaked, Shaked, Sheng, Siemann, Siemann, Siemann, Stratford, Tavora, Tozer, Tozer, Tozer, Tozer, Tozer, Uehata, Vincent, Wang, Welford, Workman   +57 more
core   +1 more source

Effect of N‐Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy

Journal of clinical pharmacology, 2019
Hydralazine, an antihypertensive agent used during pregnancy, undergoes N‐acetylation primarily via N‐acetyltransferase 2 (NAT2) to form 3‐methyl‐1,2,4‐triazolo[3,4‐a]phthalazine (MTP).
Lyrialle W. Han, Rachel Ryu, Michael Cusumano, T. Easterling, Brian R. Phillips, L. Risler, D. Shen, M. Hebert   +7 more
semanticscholar   +1 more source

Cryptococcid Sweet Syndrome in the Setting of Hydralazine‐Induced ANCA Vasculitis: A Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Acute febrile neutrophilic dermatosis, also known as Sweet syndrome, is an inflammatory skin condition characterized by the rapid onset of painful, erythematous plaques or nodules with neutrophilic infiltrate on histology. Rarely, acellular bodies surrounded by vacuolated spaces have been noted within the neutrophilic infiltrate, mimicking ...
Jenna Vroman, Pelin Sagut, Kathryn Lynam, Amanda Ederle, Laura Winterfield   +4 more
wiley   +1 more source

Hydralazine Induces Myeloperoxidase and Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody Vasculitis and Leads to Pulmonary Renal Syndrome

Case Reports in Nephrology, 2014
We report a case of hydralazine-induced ANCA-associated glomerulonephritis with pulmonary hemorrhage. A 62-year-old Hispanic man with hypertension, who was being treated with hydralazine 100 mg three times a day for four and half years, presented to the ...
Gaurav Agarwal, Ghayyath Sultan, Sherry L. Werner, Claudia Hura   +3 more
doaj   +1 more source

The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study

Virology Journal, 2007
Background The methylation status at the human papilloma virus (HPV) genome found in pre-invasive and invasive cervical lesions suggests that neoplastic transformation can be suppressed by gene hypermethylation, whereas hypomethylation accompanies or ...
de la Cruz-Hernández Erick, Pérez-Cárdenas Enrique, Contreras-Paredes Adriana, Cantú David, Mohar Alejandro, Lizano Marcela, Dueñas-González Alfonso   +6 more
doaj   +1 more source

Race, Money and Medicines [PDF]

, 2006
Taking notice of race is both risky and inevitable, in medicine no less than in other endeavors. The literature on race as a classifying tool in clinical research poses this core dilemma: On the one hand, race can be a useful stand-in for unstudied ...
Bloche, Maxwell Gregg
core   +1 more source

Clinical Characteristics of Hydralazine-induced Lupus

Cureus, 2019
Introduction The use of hydralazine has been associated with the development of lupus erythematosus and lupus-like syndromes. We performed this retrospective study to identify clinical characteristics of individuals who developed hydralazine-induced ...
H. Timlin, Michael Wu, Mónica Crespo-Bosque, D. Geetha, Ashley Ingolia, U. Haque, M. Towns, Thomas Grader-Beck   +7 more
semanticscholar   +1 more source

Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
wiley   +1 more source