Results 71 to 80 of about 22,486 (258)

Hydralazine combined with conventional therapy improved outcomes in severe systolic dysfunction and mitral regurgitation

ESC Heart Failure
Aims Patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF) accompanied by significant mitral regurgitation (MR) had poor outcome. Several vasodilator trials showed neutral results.
Shih‐Hung Hsiao, Chao‐Sheng Hsiao, Jau‐Wen Shiau, Kuan‐Rau Chiou   +3 more
doaj   +1 more source

Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Nature Communications, 2019
Hydralazine is a drug used in the treatment of heart failure and cancer, and it has recently been shown to promote lifespan in C. elegans. Here, the authors elucidate the mechanism of action of hydralazine, and show that it targets PKA to promote ...
Esmaeil Dehghan, Mohammad Goodarzi, Bahar Saremi, Rueyling Lin, Hamid Mirzaei   +4 more
doaj   +1 more source

Hydrazine compounds inhibit glycation of low-density lipoproteins and prevent the in vitro formation of model foam cells from glycolaldehyde-modified low-density lipoproteins [PDF]

, 2006
Aims/hypothesis: Previous studies have shown that glycation of LDL by methylglyoxal and glycolaldehyde, in the absence of significant oxidation, results in lipid accumulation in macrophage cells. Such 'foam cells' are a hallmark of atherosclerosis.
Brown, BE, Cook, NL, Davies, MJ, Mahroof, FM, Van Reyk, DM   +4 more
core   +1 more source

Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma

Clinical Endocrinology, Volume 103, Issue 1, Page 21-35, July 2025.
ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder, Cherie Chiang, Grace Kong, Michael Michael, Nirupa Sachithanandan, Emma Boehm   +5 more
wiley   +1 more source

A Challenging Twist in Pulmonary Renal Syndrome

Case Reports in Rheumatology, 2014
Case. We report a rare case of hydralazine-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. A 75-year-old African American woman with history of high blood pressure on hydralazine for 3 years presented with acute onset of shortness of ...
Rajaie Namas, Bernard Rubin, Wamidh Adwar, Alireza Meysami   +3 more
doaj   +1 more source

Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review. [PDF]

, 2014
BACKGROUND: Pregnant and postpartum women with severe hypertension are at increased risk of stroke and require blood pressure (BP) reduction. Parenteral antihypertensives have been most commonly studied, but oral agents would be ideal for use in busy and
Community Level Interventions for Pre-eclampsia (CLIP) Working G, CLIP, Firoz, T, Gordon, R, MacDonell, K, Magee, LA, Payne, BA, Vidler, M, von Dadelszen, P   +7 more
core   +1 more source

Baseline kidney function and the effects of dapagliflozin on health status in heart failure in DEFINE‐HF and PRESERVED‐HF

ESC Heart Failure, Volume 12, Issue 3, Page 1676-1681, June 2025.
Abstract Aims Sodium–glucose co‐transporter‐2 (SGLT2) inhibitors improve health status and outcomes in the setting of heart failure (HF) across the range of ejection fraction (EF). Baseline kidney disease is common in HF, complicates HF management and is strongly linked to worse health status. This study aimed to assess whether the treatment effects of
Andrew P. Ambrosy, Andrew J. Sauer, Shachi Patel, Sheryl L. Windsor, Barry A. Borlaug, Mansoor Husain, Silvio E. Inzucchi, Dalane W. Kitzman, Darren K. McGuire, Sanjiv J. Shah, Kavita Sharma, Guillermo Umpierrez, Mikhail N. Kosiborod   +12 more
wiley   +1 more source

Rare complication of a commonly used antihypertensive agent: A case of hydralazine‐induced ANCA‐associated vasculitis presenting as rapidly progressive glomerulonephritis

Clinical Case Reports, 2022
Hydralazine‐induced ANCA‐associated vasculitis is a rare clinical entity, with complications including rapidly progressive glomerulonephritis, pulmonary hemorrhage, and pulmonary‐renal syndrome.
Kayle Warren, Khiem Vu, Karandeep Shergill, Brian Watson, Mohamed Faris   +4 more
doaj   +1 more source

Use of Hydralazine‐Isosorbide Dinitrate Combination in African American and Other Race/Ethnic Group Patients With Heart Failure and Reduced Left Ventricular Ejection Fraction [PDF]

, 2013
Background: Hydralazine‐isosorbide dinitrate (H‐ISDN) therapy is recommended for African American patients with moderate to severe heart failure with reduced ejection fraction (
Bhatt, Deepak L., Butler, Javed, Fonarow, Gregg C., Golwala, Harsh B., Hernandez, Adrian F., Liang, Li, Stavrakis, Stavros, Thadani, Udho, Yancy, Clyde W.   +8 more
core   +1 more source

Guideline‐directed medical therapy rates in heart failure patients with reduced ejection fraction in a diverse cohort

ESC Heart Failure, Volume 12, Issue 3, Page 1861-1871, June 2025.
Abstract Aims Guideline‐directed medical therapy (GDMT) is recommended for all patients with heart failure with reduced ejection fraction (HFrEF). Despite this, little data exist describing GDMT use in diverse, real‐world populations including the use of vasodilators, prescribed primarily to Black populations.
Natalia C. Berry, Yi‐Shin Sheu, Karen Chesbrough, R. Clayton Bishop, Suma Vupputuri   +4 more
wiley   +1 more source