Results 261 to 270 of about 59,471 (323)

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

Small Methods, Volume 10, Issue 2, 22 January 2026.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz, Nima Pourafzal, Audrey T. Zhu, Zhongyuan Guo, Ronnie H. Fang, Liangfang Zhang   +5 more
wiley   +1 more source

Room-temperature synthesis of silver-based nanoparticle-embedded hydrogel material <i>via</i> catalytic crosslinking for recyclable dye degradation applications. [PDF]

RSC Adv
Jagankar D, Das N, Mukherjee A, Maity C.
europepmc   +1 more source

Diabetes Induces Accumulation of Carbonylated Proteins in the Rat Retinal Pigment Epithelium Independently of Oxidative Stress

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
The retinal pigment epithelium (RPE) plays a crucial role in retinal function, regulating the flow of metabolites and ions between the choroidal blood supply and the outer retina. Early hyperglycemia induced by streptozotocin results in elevated levels of oxidized proteins and lipid peroxidation.
Elena Morales‐Ramírez, Juan David Villeda‐González, Gustavo Sánchez‐Chávez, Rocío Salceda   +3 more
wiley   +1 more source

Polymer Nanomedicines with pH-Triggered Pirarubicin Release: Revealing the Role of Carrier Hydrophilicity and Release Kinetics in Anticancer Performance. [PDF]

Biomacromolecules
Pytlíková S, Jiang B, Woldřichová L, Kotalík K, Androvič L, Gao S, Šubr V, Rumlerová A, Pola R, Podhorská N, Filipová M, Zhang M, Pechar M, Fang J, Laga R, Etrych T.   +15 more
europepmc   +1 more source

Design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors

, 2014
Rafiqul Islam, Fumiaki Koizumi, Yasuo Kodera, Kengo Inoue, Tadashi Okawara, Mitsuko Masutani   +5 more
openalex   +1 more source

Memantine Confers Multi‐Target Protection in a Zebrafish Seizure Model: Attenuating Epileptic Behavior, GluN2A Overexpression, and Oxidative Stress

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Approximately 30% of epilepsy patients do not respond to current medications. In addition, the pharmaceutical industry is reducing its interest in de novo drug discovery for epilepsy. Drug repurposing offers a promising alternative. This study investigated memantine, an Alzheimer's drug, in a zebrafish model of seizures.
Kamila Cagliari Zenki, Eduardo Kalinine, Ben Hur Marins Mussulini, Thainá Garbino dos Santos, Lucia von Mengden, Fábio Klamt, Suelen Baggio, Ana Carolina de Moura, Ana Beatriz Gorini da Veiga, Diogo Losch de Oliveira   +9 more
wiley   +1 more source

Rational design, synthesis of some quinolinone-Schiff bases/ pyridazino[4,5-c]quinolinones with potent anti-lung cancer and antituberculosis performance. [PDF]

Sci Rep
Ghaith EA, Elnaggar NN, Hamama WS.
europepmc   +1 more source

Bioenergetic profiles and respiratory control in mitochondrial physiology: Precision analysis of oxidative phosphorylation

Experimental Physiology, Volume 111, Issue 1, Page 179-211, 1 January 2026.
Abstract Oxidative phosphorylation (OXPHOS) is fundamental to mitochondrial function. Respirometry with living cells provides limited information compared to precision OXPHOS analysis with mitochondrial preparations, including isolated mitochondria, tissue homogenates, permeabilized tissues, and permeabilized cells.
Alba Timón‐Gómez, Carolina Doerrier, Zuzana Sumbalová, Luiz F. Garcia‐Souza, Eleonora Baglivo, Luiza H. D. Cardoso, Erich Gnaiger   +6 more
wiley   +1 more source

Furan-thiazole hydrazone scaffolds as promising antitubercular and antibacterial agents: synthesis, characterization, bioevaluation and computational analysis. [PDF]

RSC Adv
Sable YR, Shinde RA, Yasin HKA, Ghanwate N, Mali SN, Ghotekar SK, Gawari DP, Sasane DA, Adole VA.   +8 more
europepmc   +1 more source

Advancements in Alginate‐Based Biomaterials for Enhanced Skin Regeneration: A Comprehensive Review

International Journal of Polymer Science, Volume 2026, Issue 1, 2026.
Alginate, a naturally occurring polysaccharide composed of β‐d‐mannuronate (M) and α‐l‐guluronate (G), has attracted widespread attention for skin regeneration applications due to its exceptional biocompatibility, biodegradability, and tunable physicochemical properties. Beyond its traditional role in maintaining a moist wound environment and providing
Nasrul Wathoni, Anita Salsabila Herginto, Cecep Suhandi, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, Safwat A. Mahmoud, Raden M. Febriyanti, Gofarana Wilar, Yihu Song   +8 more
wiley   +1 more source