Results 61 to 70 of about 562 (194)
Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives
Molecules, 2012 New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine.
Mohamed R. Abdel Aziz +2 more
doaj +1 more source
Site-selectivite Synthesis and Tautomerism of Arylazo Derivatives of Pyrazolo[3,4-d]pyrimido-[1,6-b][1,2,4]triazine [PDF]
, 2008 A simple synthetic strategy is described for synthesis of the hitherto unreported 5-arylazo-1,3-diphenyl-6-substituted-1H-pyrazolo[3,4-d]pyrimido[1,6-b][1,2,4]triazines 5a-n.
Darwish, Manal A. A. +3 more
core
ChemistryOpen, EarlyView.New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha +6 more
wiley +1 more source
Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles
International Journal of Medicinal Chemistry, Volume 2013, Issue 1, 2013., 2013 The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4‐thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent ...
Bhawna Sharma +4 more
wiley +1 more source
Molecules, 2012 A number of interesting heterocycles were prepared through interaction of the intermediate 3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno-[2,3-d]pyrimidine (1) and reagents such as hydrazonyl halides 2 to furnish triazine derivatives
Sobhi M. Gomha, Mohamed G. Badrey
doaj +1 more source
Regioselective Catalytic Synthesis of Potentially Bioactive 1,3,4-Selenadiazole [PDF]
, 2023 Isoselenocyanates have a crucial role as reactants in chemical processes, facilitating the efficient synthesis of significant chemical intermediates and physiologically active chemicals.
Mahmoud, Mohamed Ali
core +1 more source
Novel Antimicrobial Agents: Fluorinated 2‐(3‐(Benzofuran‐2‐yl) pyrazol‐1‐yl)thiazoles
International Journal of Medicinal Chemistry, Volume 2013, Issue 1, 2013., 2013 A new series of 2‐pyrazolin‐1‐ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N‐thiocarboxamide‐2‐pyrazoline with different haloketones and 2,3‐dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data.
Hanan A. Mohamed +4 more
wiley +1 more source
Molecules, 2018 The one-pot synthesis of a series of pyrazoline derivatives containing the bioactive thiazole ring has been performed through a 1,3-dipolar cycloaddition reaction of N-thiocarbamoylpyrazoline and different hydrazonoyl halides or α-haloketones in the
Mastoura M. Edrees +5 more
doaj +1 more source
Synthesis of New Azoles and Azolopyrimidines Incorporating Morpholine Moiety as Potent Anti-Tumor Agents [PDF]
, 2018 A new series of morpholinyl-chalcones 2a–d was prepared by reaction of 2-oxo-N,4-diarylbut-3-enehydrazonoyl chlorides 1a–d with morpholine. These chalcones were used as a building block for constructing pyrazoles 3a–d and 3,4-dihydropyrimidine-2(1H ...
Elham Ezz El-Arab +3 more
core +2 more sources
Synthesis of new derivatives of the 1H-1,2,3-triazole ring using 1-aryl-5-phenyl-1H-1,2,3-triazole-4-carbohydrazides as precursors [PDF]
, 2023 Condensation of 1-(4-nitrophenyl)-5-phenyl-1H-1,2,3-triazole-4-carbohydrazide and phenyl isothiocyanate in ethanol in the presence of a catalytic quantity of triethylamine under reflux gave 5-(1-(4-nitrophenyl)-5-phenyl-1H-1,2,3-triazol-4-yl)-N-phenyl-1 ...
Abdel-Wahab, Bakr F. +4 more
core +1 more source