Results 91 to 100 of about 123,936 (336)

Hypertension and Severe Hypokalemia Associated With Oral Ingestion of Topical Hydrocortisone Cream

AACE Clinical Case Reports, 2023
Background: Topical use of corticosteroids causes systemic effects, but systemic toxicity by ingesting topical corticosteroid cream has not been reported. We describe a patient admitted with ingestion of over-the-counter (OTC) hydrocortisone cream.
Arunava Saha, MD, Suryanarayanan Balakrishnan, MD, Nitin Trivedi, MD, George M. Abraham, MD, MPH, MACP   +3 more
doaj  

Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes. [PDF]

, 2020
Inorganic arsenic oxides have been identified as carcinogens in several human tissues, including epidermis. Due to the chemical similarity between trivalent inorganic arsenic (arsenite) and antimony (antimonite), we hypothesized that common intracellular
Cánovas, Angela, Durbin-Johnson, Blythe, Islas-Trejo, Alma, Medrano, Juan F, Phillips, Marjorie A, Rea, Miguel A, Rice, Robert H, Rocke, David M   +7 more
core  

Permission form synopses to improve parents' understanding of research: a randomized trial. [PDF]

, 2017
ObjectiveWe hypothesized that, among parents of potential neonatal research subjects, an accompanying cover sheet added to the permission form (intervention) would increase understanding of the research, when compared to a standard form (control).Study ...
Chess, PR, D'Angio, CT, Hunn, JE, Lakshminrusimha, S, Pryhuber, GS, Wang, H   +5 more
core   +1 more source

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression

Advanced Science, EarlyView.
Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi, Yining Zhang, Lydia Sakala, Twinkle Jina Minette Manoharan, Barbara Pockaj, Joshua LaBaer, Jin G. Park, Mehdi Nikkhah   +7 more
wiley   +1 more source

Glucocorticoid therapy for adrenal insufficiency: nonadherence, concerns and dissatisfaction with information [PDF]

, 2016
Objective: Appropriate self‐management of glucocorticoid therapy (GC) is crucial for patients with adrenal insufficiency (AI). We aimed to describe patients’ self‐reported nonadherence to GC, evaluate perceived doubts about need for GC, concerns about ...
Carroll, P., Chapman, S. C. E, Horne, R., Llahana, S.   +3 more
core   +2 more sources

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

Role of very short-term intravenous hydrocortisone in reducing postdural puncture headache

Journal of Anaesthesiology Clinical Pharmacology, 2012
Objective: Headache is not an uncommon complication of spinal anesthesia. The efficacy of intravenous (IV) hydrocortisone in treating the patients with postdural puncture headache was observed in this study.
Md Rabiul Alam, Md Aminur Rahman, Reza Ershad   +2 more
doaj   +1 more source

AKT1E17K‐Interacting lncRNA SVIL‐AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation

Advanced Science, EarlyView.
Wang et al. discover a novel lncRNA regulator of mutant oncoprotein which prevents AKT1E17K dephosphorylation. SVIL‐AS1 overexpression correlates with poor prognosis of breast cancer patients. It interacts with AKT1E17K protein and impedes PP2A holoenzyme from dephosphorylating AKT1 by blocking the binding of the regulatory subunit PPP2R2A to AKT1 ...
Jingyi Wang, Wenying Chen, Qianying Li, Ruiyi Yang, Xiaorong Lin, Ping Han, Xiaoming Huang, Hai Hu, Man‐Li Luo   +8 more
wiley   +1 more source

Antiemetic efficacy of high-dose hydrocortisone in patients receiving cisplatin therapy [PDF]

, 1986
Cisplatin療法にhydrocortisone succinateを使用し, 消化器合併症を4段階評価で査定した.1) Cisplatin 7～20 mg/m2/日×5日間を中心とする多剤併用療法にhydrocortisone 900～1, 800 mg/日を使用した場合, 嘔気, 嘔吐回数, 食欲不振の症状は有意に軽減した.2) Cisplatin 30～40 mg/m2/日×1日を中心とする多剤併用療法では, hydrocortisone 1, 500～2, 400 mgの使用は ...
坂田, 安之輔, 小松原, 秀一, 峰山, 浩忠, 渡辺, 学, 阿部, 禮男   +4 more
core  

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases [PDF]

, 2005
Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of ...
Atsuta J, Boner AL, Bridgman A, Callen J, Delescluse J, Dooms-Goossens AE, Dykes PJ, Falcoz C, Fisher DA, Goossens A, Harding SM, Hogger P, James M, Johnson M, Johnson M, Juhlin L, Katz HI, Korting HC, Lebwohl M, Li JT, Liu XQ, Llewellyn-Jones CG, Lucky AW, McKenzie AW, McLean HM, Nurnberger FG, Phillipps GH, Roberts DT, Spencer CM, Tharp MD, Venning VA, Wilkinson SM, Wolkerstorfer A, Young MMR   +33 more
core   +1 more source