Results 31 to 40 of about 87,509 (230)

Effect of low-dose hydrocortisone and inhaled nitric oxide on inflammatory mediators and local pulmonary metalloproteinases activity in LPS-induced sepsis in piglets

Scientific Reports, 2023
Hospital mortality in sepsis varies between 30–45%. It has been shown that administration of inhaled nitric oxide (iNO) and intravenous corticosteroid in a porcine endotoxemia model attenuated the systemic inflammatory response.
Liliana Kiczak, Urszula Pasławska, Waldemar Goździk, Barbara Adamik, Marzena Zielińska, Stanisław Zieliński, Kacper Nowak, Michał Płóciennik, Jacek Bania, Aleksandra Tabiś, Marcin Nowak, Robert Pasławski, Claes Frostell   +12 more
doaj   +1 more source

A Versatile Engineering Platform for the Fabrication of Prosthetic Venous Valves Using Electrospinning

Advanced Healthcare Materials, EarlyView.
Percutaneous prosthetic venous valves are fabricated by embedding stents in an electrospun matrix that extends luminally to form leaflets. The design shields leaflets from hyperplastic cells, isolates struts from blood contact, and avoids discrete anchoring points.
Dario Arcuti, Salma Mansi, Dominic Biebl, Malin Reuter, Maximilian Grab, José Carlos Rodríguez‐Cabello, Petra Mela   +6 more
wiley   +1 more source

Preventive efficacy of hydrocortisone enema for radiation proctitis in rectal cancer patients undergoing short-course radiotherapy: a phase II randomized placebo-controlled clinical trial [PDF]

Annals of Coloproctology
Purpose This study aimed to investigate the efficacy of hydrocortisone enema in preventing radiation proctitis in patients with rectal cancer undergoing short-course radiotherapy (SCRT). Methods This phase II randomized controlled trial enrolled patients
Mohammad Mohammadianpanah, Maryam Tazang, Nam Phong Nguyen, Niloofar Ahmadloo, Shapour Omidvari, Ahmad Mosalaei, Mansour Ansari, Hamid Nasrollahi, Behnam Kadkhodaei, Nezhat Khanjani, Seyed Vahid Hosseini   +10 more
doaj   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

High Stability of Diketopyrrolopyrrole Polymer Transistors Under Aqueous Condition Toward Biosensing Platform

Advanced Materials Technologies, EarlyView.
We are reporting the first‐time investigation of DPP‐based Organic Field‐Effect Transistor (OFET) devices with high‐stability of signal response in both of ambient and aqueous conditions with PBS solution. ABSTRACT Diketopyrrolopyrrole (DPP)–based conjugated polymers show strong promise for electronic applications, including bioelectronic gas sensors ...
Chattarika Khamhanglit, Yudai Hemmi, Ami Ichikawa, YuanTong Gu, Kuniaki Nagamine, Hiroyuki Matsui, Prashant Sonar   +6 more
wiley   +1 more source

Early low-dose hydrocortisone is associated with a reduced risk of bronchopulmonary dysplasia in infants born at less than 26 weeks' gestational age

Frontiers in Pediatrics
ObjectiveTo determine whether administering low-dose hydrocortisone early in treatment reduces the risk of bronchopulmonary dysplasia (BPD) in infants born before 26 weeks of gestationStudy designThis retrospective case-control study compared the ...
Fang Yao, Fang Yao, Fang Yao, Zhifeng Huang, Xueyu Chen, Xueyu Chen, Chuanzhong Yang, Chuanzhong Yang, Qiuping Li, Qiuping Li, Bingchun Lin   +10 more
doaj   +1 more source

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Glucocorticoid susceptibility and in vivo ABCB1 activity differ in murine B cell subsets

Anais da Academia Brasileira de Ciências
Glucocorticoids are produced and released by the adrenal gland and become elevated in response to stress. Although glucocorticoids are well known for their immunosuppressive effects, less is known about their effects on B cells.
KELLI M. DA COSTA, RAPHAEL C. VALENTE, JOYLE M.C. DA SILVA, LUCIANA S. DE PAIVA, VIVIAN M. RUMJANEK   +4 more
doaj   +1 more source

Adrenal Insufficiency under Standard Dosage of Glucocorticoid Replacement after Unilateral Adrenalectomy for Cushing’s Syndrome

Case Reports in Endocrinology, 2016
Glucocorticoid replacement is needed for patients after adrenal surgery for Cushing’s syndrome; however, the adequate dosage is not easily determined.
Kentaro Fujii, Kazutoshi Miyashita, Isao Kurihara, Ken Hiratsuka, Seiji Sato, Kenichi Yokota, Sakiko Kobayashi, Hirotaka Shibata, Hiroshi Itoh   +8 more
doaj   +1 more source

Protective effect of early low-dose hydrocortisone on ventilator-associated pneumonia in the cancer patients: a propensity score analysis

Annals of Intensive Care, 2017
Background Ventilator-associated pneumonia (VAP) is a care-related event that could be promoted by immune suppression caused by critical diseases, malignancies and cancer treatments.
David Lagier, Laura Platon, Jérome Lambert, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Jean-Paul Brun, Karim Asehnoune, Marc Leone, Marion Faucher, Djamel Mokart   +10 more
doaj   +1 more source