Results 81 to 90 of about 123,936 (336)
Advanced Science, EarlyView.Extracellular matrix (ECM) viscoelasticity and spatial confinement regulate cellular processes such as cancer progression, yet their interplay remains poorly understood. By developing fibronectin (FN)‐micropatterned viscoelastic hydrogels mimicking breast cancer mechanics, this study explores breast epithelial cell mechanoresponse to ECM ...
Giuseppe Ciccone +6 more
wiley +1 more source
A physical model of nicotinic ACh receptor kinetics [PDF]
arXiv, 2008 We present a new approach to nicotinic receptor kinetics and a new model explaining random variabilities in the duration of open events. The model gives new interpretation on brief and long receptor openings and predicts (for two identical binding sites) the presence of three components in the open time distribution: two brief and a long.
arxiv
Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone [PDF]
, 2014 A physical and chemically stable palm kernel oil esters emulsion system with nanosized droplet was developed as a delivery system for hydrocortisone (hydrophobic drug). A simple low energy emulsification method was used in forming the nanoemulsions.
Basri, Hamidon +3 more
core +1 more source
From Lab to Life: Self‐Powered Sweat Sensors and Their Future in Personal Health Monitoring
Advanced Science, EarlyView.This review focuses on recent advances in self‐powered sweat sensors in personal health monitoring, including sweat sensors, energy harvesters, energy management, and their applications. It analyzes the difficulties and challenges in the research field of self‐powered sweat sensors and looks into the future direction of self‐powered sweat sensors from ...
Nan Gao +3 more
wiley +1 more source
Hydrocortisone dose in adrenal insufficiency:Balancing harms and benefits [PDF]
, 2017 Patients with secondary adrenal insufficiency do not produce cortisol and are therefore treated with hydrocortisone tablets. The optimal substitution dose for hydrocortisone is unknown.
Werumeus Buning, Jorien
core +2 more sources
Advanced Science, EarlyView.This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran +7 more
wiley +1 more source
ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022 Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen +3 more
wiley +1 more source
Nocturnal Dexamethasone versus Hydrocortisone for the Treatment of Children with Congenital Adrenal Hyperplasia [PDF]
, 2010 Classic congenital adrenal hyperplasia affects approximately 1 in 15,000 children. Current treatment strategies using multiple daily doses of hydrocortisone lead to suboptimal outcomes.
Dauber, Andrew +2 more
core +3 more sources
Epileptiform Activity and Seizure Risk Follow Long‐Term Non‐Linear Attractor Dynamics
Advanced Science, EarlyView.This study leverages the HAVOK framework to model long‐term, nonlinear attractor dynamics underlying epileptiform activity and seizure risk in epilepsy patients. By identifying key forcing mechanisms driving chaotic transitions, the findings improve seizure risk forecasting over multi‐day cycles and provide a pathway for personalized, data‐driven ...
Richard E Rosch +4 more
wiley +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila +11 more
wiley +1 more source