Results 31 to 40 of about 679,248 (331)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Hydrogen-Ion Concentration Gradient in Plants [PDF]
American Journal of Botany, 1924 Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/141536/1/ajb205753 ...
openaire +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Neutron and X-ray diffraction studies on complex liquids [PDF]
, 2002 The above examples illustrate the extent to which present day neutron and X-ray diffraction methods are being used to determine interatomic structure in a wide range of liquid and amorphous systems.
Adya, Ashok K. +2 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
AVALIAÇÃO DA QUALIDADE DE CREMES DERMATOLÓGICOS MANIPULADOS NA CIDADE DE MARÍLIA, SP
Colloquium Vitae, 2009 The magistral pharmacy represents an important segment in the national market of pharmacy and since the RDC 67/2007, will have to follow the new rules to guarantee more security, quality and efficacy of the manipulated formulae.
Leandra Aparecida B. Rigato +4 more
doaj +1 more source
Effect of high temperature heat treatments on the quality factor of a large-grain superconducting radio-frequency niobium cavity [PDF]
, 2013 Large-grain Nb has become a viable alternative to fine-grain Nb for the fabrication of superconducting radio-frequency cavities. In this contribution we report the results from a heat treatment study of a large-grain 1.5 GHz single-cell cavity made of ...
Ciovati, G. +12 more
core +4 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Value of Rumex Acetosella as an Acid Indicator [PDF]
, 1931 Among laymen and agriculturists it is a common expression that certain spots in a field are acid. The term acid spots has come to be used more and more since soil reaction has been shown to have some bearing upon the soil preferences of many plants ...
Artist, Russell
core +1 more source