Results 51 to 60 of about 297,801 (378)

Serine ADP-ribosylation reversal by the hydrolase ARH3

eLife, 2017
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of ADPr,
P. Fontana, J. Bonfiglio, L. Palazzo, Edward J. Bartlett, I. Matic, Ivan Ahel   +5 more
semanticscholar   +1 more source

Identification of a Novel Thermostable Alkaline Protease from Bacillus megaterium-TK1 for the Detergent and Leather Industry

Biology, 2020
An increased need by the green industry for enzymes that can be exploited for eco-friendly industrial applications led us to isolate and identify a unique protease obtained from a proteolytic Bacillus megaterium-TK1 strain from a seawater source.
Tamilvendan Manavalan, Arulmani Manavalan, Shiyamsundar Ramachandran, Klaus Heese   +3 more
doaj   +1 more source

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Alphaviruses are mosquito-borne RNA viruses that cause encephalitis, rash, and arthritis. Alphavirus nonstructural protein 3 (nsP3) has a highly conserved macrodomain that can bind and remove ADP-ribose (ADPr) residues from ADP-ribosylated ...
Rachy Abraham, D. Hauer, R. McPherson, Age Utt, I. T. Kirby, Michael S. Cohen, A. Merits, A. Leung, D. Griffin   +8 more
semanticscholar   +1 more source

Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. [PDF]

, 2014
BackgroundBacteroides spp. form a significant part of our gut microbiome and are well known for optimized metabolism of diverse polysaccharides. Initial analysis of the archetypal Bacteroides thetaiotaomicron genome identified 172 glycosyl hydrolases and
Axelrod, Herbert L, Chang, Yuanyuan, Eberhardt, Ruth Y, Godzik, Adam, Li, Zhanwen, Rigden, Daniel J, Sheydina, Anna, Zmasek, Christian C   +7 more
core   +2 more sources

β-Glucan is a major growth substrate for human gut bacteria related to Coprococcus eutactus [PDF]

, 2020
A clone encoding carboxymethyl cellulase activity was isolated during functional screening of a human gut metagenomic library using Lactococcus lactis MG1363 as heterologous host.
Alessi, Anna M, Collie-Duguid, Elaina S R, Farquharson, Freda M, Flint, Harry J, Flores-López, Adriana, Gasson, Mike, Gray, Victoria, Louis, Petra, Shaw, Sophie, Shearman, Claire, Stead, David, Wegmann, Udo   +11 more
core   +3 more sources

IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?

Pathogens, 2023
Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids
Katharina Biaesch, Sarah Knapp, Patricia Korn   +2 more
doaj   +1 more source

GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase), with data on DNA, on the protein encoded, and where the gene is implicated.
Cheng, Q, Evans, WE
openaire   +3 more sources

Computational redesign of a hydrolase for nearly complete PET depolymerization at industrially relevant high-solids loading

Nature Communications
Biotechnological plastic recycling has emerged as a suitable option for addressing the pollution crisis. A major breakthrough in the biodegradation of poly(ethylene terephthalate) (PET) is achieved by using a LCC variant, which permits 90% conversion at ...
Yinglu Cui, Yanchun Chen, Jinyuan Sun, Tong Zhu, Hua Pang, Chunli Li, Wen-Chao Geng, Bian Wu   +7 more
semanticscholar   +1 more source

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria

Frontiers in Microbiology, 2018
MacroD1 is a macrodomain containing protein that has mono-ADP-ribose hydrolase enzymatic activity toward several ADP-ribose adducts. Dysregulation of MacroD1 expression has been shown to be associated with the pathogenesis of several forms of cancer.
Thomas Agnew, Deeksha Munnur, Kerryanne Crawford, Luca Palazzo, Andreja Mikoč, Ivan Ahel   +5 more
doaj   +1 more source

Purification, Characterization, and Structural Studies of a Sulfatase from Pedobacter yulinensis

Molecules, 2021
Sulfatases are ubiquitous enzymes that hydrolyze sulfate from sulfated organic substrates such as carbohydrates, steroids, and flavones. These enzymes can be exploited in the field of biotechnology to analyze sulfated metabolites in humans, such as ...
Caleb R. Schlachter, Andrea O’Malley, Linda L. Grimes, John J. Tomashek, Maksymilian Chruszcz, L. Andrew Lee   +5 more
doaj   +1 more source