EnzyKR: A Chirality-Aware Deep Learning Model for Predicting the Outcomes of the Hydrolase-Catalyzed Kinetic Resolution [PDF]
, 2023 Hydrolase-catalyzed kinetic resolution is a well-established biocatalytic process. However, the computational tools that predict the favorable enzyme scaffolds for separating racemic substrate mixture are underdeveloped.
Xinchun, Ran +3 more
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Functional analysis of four bile salt hydrolase and penicillin acylase family members in Lactobacillus plantarum WCFS1 [PDF]
, 2008 Bile salts play an important role in the digestion of lipids in vertebrates and are synthesized and conjugated to either glycine or taurine in the liver.
Lambert, J.M. +4 more
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Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (
Human Genomics, 2010 The acyl-CoA thioesterase gene (ACOT) family encodes enzymes that catalyse the hydrolysis of acyl-CoA thioester compounds, also known as activated fatty acids, to their corresponding non-esterified (free) fatty acid and coenzyme A (CoASH).
Brocker Chad +3 more
doaj +1 more source
Enzymatic Modification of Pomace Olive Oil with Natural Antioxidants: Effect on Oxidative Stability
Biomolecules, 2023 Enzymatic lipophilization has been proposed as a cost-effective strategy to produce new liposoluble antioxidant compounds. In this study, modified oils rich in structured phenolipids were prepared via one-pot enzymatic acylation of hydroxytyrosol (HTYR),
Renia Fotiadou +5 more
doaj +1 more source
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]
, 2011 Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd +39 more
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Microbiology Spectrum, 2022 Peptidoglycan (PG) hydrolases, due to their crucial role in the metabolism of the bacterial cell wall (CW), are increasingly being considered suitable targets for therapies, and a potent alternative to conventional antibiotics.
Alicja Wysocka +3 more
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A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The discovery of allosteric modulators is a multi-disciplinary approach, which is time- and cost-intensive. High-throughput screening combined with novel computational tools can reduce these factors. Thus, we developed an enzyme activity assay, which can
Ariane Menden +7 more
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Chemistry, 2023 The de novo design and synthesis of peptide-based biocatalysts that can mimic the activity of natural enzymes is an exciting field with unique opportunities and challenges.
Soumya Patra +4 more
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Improved annotation of conjugated bile acid hydrolase superfamily members in Gram-positive bacteria. [PDF]
, 2008 Contains fulltext : 69805.pdf (Publisher’s version ) (Closed access)Most Gram-positive bacteria inhabiting the gastrointestinal tract are capable of hydrolysing bile salts.
Lambert, J.M. +5 more
core +2 more sources
Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. [PDF]
, 2011 Arabidopsis thaliana AtNUDT7 Nudix pyrophosphatase hydrolyzes NADH and ADP-ribose in vitro and is an important factor in the cellular response to diverse biotic and abiotic stresses.
Olejnik, Kamil +7 more
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