Results 21 to 30 of about 183,842 (201)

Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family

Human Genomics, 2010
The acyl-CoA thioesterase gene (ACOT) family encodes enzymes that catalyse the hydrolysis of acyl-CoA thioester compounds, also known as activated fatty acids, to their corresponding non-esterified (free) fatty acid and coenzyme A (CoASH).
Brocker Chad, Carpenter Christopher, Nebert Daniel W, Vasiliou Vasilis   +3 more
doaj   +1 more source

Metabolite Damage and Damage Control in a Minimal Genome

mBio, 2022
Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes known to have such functions were identified and experimentally validated,
Drago Haas, Antje M. Thamm, Jiayi Sun, Lili Huang, Lijie Sun, Guillaume A. W. Beaudoin, Kim S. Wise, Claudia Lerma-Ortiz, Steven D. Bruner, Marian Breuer, Zaida Luthey-Schulten, Jiusheng Lin, Mark A. Wilson, Greg Brown, Alexander F. Yakunin, Inna Kurilyak, Jacob Folz, Oliver Fiehn, John I. Glass, Andrew D. Hanson, Christopher S. Henry, Valérie de Crécy-Lagard   +21 more
doaj   +1 more source

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd, Gerd Geisslinger, Brandes, Ralf P., Brandes, Ralf, Michael J Fischer, Fleming, Ingrid, Scholich, Klaus, Woolf Clifford J, Ralf P Brandes, Clifford J Woolf, Fleming Ingrid, Reeh, Peter Werner, Brenneis Christian, Fischer, Michael, Coste Ovidiu, Coste, Ovidiu, Brandes Ralf P, Kai Altenrath, Reeh Peter W, Christian Brenneis, Scholich Klaus, Sisignano, Marco, Reeh, Peter W., Altenrath Kai, Ingrid Fleming, Peter W Reeh, Woolf, Clifford J., Angioni Carlo, Geisslinger Gerd, Angioni, Carlo Federico, Klaus Scholich, Brenneis, Christian, Ovidiu Coste, Carlo Angioni, Sisignano Marco, Marco Sisignano, Fischer, Michael J., Fischer Michael J, Altenrath, Kai, Angioni, Carlo   +39 more
core   +3 more sources

Enzymatic Modification of Pomace Olive Oil with Natural Antioxidants: Effect on Oxidative Stability

Biomolecules, 2023
Enzymatic lipophilization has been proposed as a cost-effective strategy to produce new liposoluble antioxidant compounds. In this study, modified oils rich in structured phenolipids were prepared via one-pot enzymatic acylation of hydroxytyrosol (HTYR),
Renia Fotiadou, Dimitrios Lefas, Despina Vougiouklaki, Aliki Tsakni, Dimitra Houhoula, Haralambos Stamatis   +5 more
doaj   +1 more source

Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. [PDF]

, 2011
Arabidopsis thaliana AtNUDT7 Nudix pyrophosphatase hydrolyzes NADH and ADP-ribose in vitro and is an important factor in the cellular response to diverse biotic and abiotic stresses.
Olejnik, Kamil, Kujawa, Martyna, Modzelan, Marta, Anielska-Mazur, Anna, Kraszewska, Elzbieta, Lipko, Agata, Bucholc, Maria, Augustyn, Agnieszka   +7 more
core   +2 more sources

A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The discovery of allosteric modulators is a multi-disciplinary approach, which is time- and cost-intensive. High-throughput screening combined with novel computational tools can reduce these factors. Thus, we developed an enzyme activity assay, which can
Ariane Menden, Davane Hall, Daniel Paris, Venkatarian Mathura, Fiona Crawford, Michael Mullan, Stefan Crynen, Ghania Ait-Ghezala   +7 more
doaj   +1 more source

Comparison of Enzymatic and Ultrasonic Extraction of Albumin from Defatted Pumpkin (Cucurbita pepo) Seed Powder

Food Technology and Biotechnology, 2015
In this study, ultrasound- and enzyme-assisted extractions of albumin (water-soluble protein group) from defatted pumpkin (Cucurbita pepo) seed powder were compared.
Gia Loi Tu, Thi Hoang Nga Bui, Thi Thu Tra Tran, Nu Minh Nguyet Ton, Van Viet Man Le   +4 more
doaj   +1 more source

Electrostatic Interaction with the Bacterial Cell Envelope Tunes the Lytic Activity of Two Novel Peptidoglycan Hydrolases

Microbiology Spectrum, 2022
Peptidoglycan (PG) hydrolases, due to their crucial role in the metabolism of the bacterial cell wall (CW), are increasingly being considered suitable targets for therapies, and a potent alternative to conventional antibiotics.
Alicja Wysocka, Łukasz Łężniak, Elżbieta Jagielska, Izabela Sabała   +3 more
doaj   +1 more source

Tweaking of Peripheral Moieties in Catalytic Amyloid for Modulating Hydrogel Strength and Hydrolase Activity

Chemistry, 2023
The de novo design and synthesis of peptide-based biocatalysts that can mimic the activity of natural enzymes is an exciting field with unique opportunities and challenges.
Soumya Patra, Nimisha A. Mavlankar, Lakshminarayan Ramesan, Ashmeet Singh, Asish Pal   +4 more
doaj   +1 more source

An inhibitor/anti-inhibitor system controls the activity of lytic transglycosylase MltF in Pseudomonas aeruginosa

mBio, 2023
Most bacterial cell envelopes contain a cell wall layer made of peptidoglycan. The synthesis of new peptidoglycan is critical for cell growth, division, and morphogenesis and is also coordinated with peptidoglycan hydrolysis to accommodate the new ...
Michelle Wang, Sheya Xiao Ma, Andrew J. Darwin   +2 more
doaj   +1 more source