Results 61 to 70 of about 297,801 (378)
Statistical modelling of transcript profiles of differentially regulated genes [PDF]
, 2008 Background: The vast quantities of gene expression profiling data produced in microarray studies, and the more precise quantitative PCR, are often not statistically analysed to their full potential.
Burton, Kerry S. +3 more
core +4 more sources
Enhanced Response of a Proteinase K-Based Conductometric Biosensor Using Nanoparticles
Sensors, 2014 Proteinases are involved in a multitude of important physiological processes, such as protein metabolism. For this reason, a conductometric enzyme biosensor based on proteinase K was developed using two types of nanoparticles (gold and magnetic).
Wided Nouira +5 more
doaj +1 more source
, 1992 We have identified a new protein fold--the alpha/beta hydrolase fold--that is common to several hydrolytic enzymes of widely differing phylogenetic origin and catalytic function.
David L. Ollis +12 more
semanticscholar +1 more source
Soluble Epoxide Hydrolase in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2010 Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim +3 more
openaire +5 more sources
PLoS Genetics, 2018 The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus aureus, (p)ppGpp is synthesized by the long RSH (RelA/SpoT homolog) enzyme, RelSau or by one of
F. Gratani +11 more
semanticscholar +1 more source
A minor alternative transcript of the fumarylacetoacetate hydrolase gene produces a protein despite being likely subjected to nonsense-mediated mRNA decay [PDF]
, 2005 BACKGROUND: Coupling of alternative splicing with nonsense-mediated mRNA decay (NMD) may regulate gene expression. We report here the identification of a nonsense alternative transcript of the fumarylacetoacetate hydrolase (fah) gene, which produces a ...
Bergeron, Anne +4 more
core +3 more sources
Toxins, 2021 The mycotoxin zearalenone (ZEN) is a frequent contaminant of animal feed and is well known for its estrogenic effects in animals. Cattle are considered less sensitive to ZEN than pigs.
Christiane Gruber-Dorninger +9 more
doaj +1 more source
Characterization of Hyaluronidase 4 Involved in the Catabolism of Chondroitin Sulfate
Molecules, 2022 Hyaluronidases (HYALs) are endo-beta-N-acetylhexosaminidases that depolymerize not only hyaluronan but also chondroitin sulfate (CS) at the initial step of their catabolism. Although HYAL1 hydrolyzes both CS and HA, HYAL4 is a CS-specific endoglycosidase.
Shuhei Yamada, Shuji Mizumoto
doaj +1 more source
Rational Engineering of Multiple Active Sites in an Ester Hydrolase.
Biochemistry, 2018 Effects of altering the properties of an active site in an enzymatic homogeneous catalyst have been extensively reported. However, the possibility of increasing the number of such sites, as commonly done in heterogeneous catalytic materials, remains ...
Gerard Santiago +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source