Results 131 to 140 of about 81,486 (244)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Pathogen-Induced Lysosomal Membrane Permeabilization: A Critical Interface Between Host Defense and Cell Death. [PDF]

Int J Mol Sci
Liu X, Li Z, Hu Y, Li T, Wang H.
europepmc   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Advances in zearalenone-degrading enzymes research: characteristics, mining, improvement, and application. [PDF]

J Anim Sci Biotechnol
Tang Y, Chen A, Guo Y, Wang Y, Zhao L.
europepmc   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update

Clinical Pharmacology &Therapeutics, EarlyView.
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard, Matthias Schwab, Michelle Whirl‐Carrillo, Ann M. Moyer, Guilherme Suarez‐Kurtz, Ching‐Hon Pui, C. Michael Stein, Teri E. Klein, Claire Spahn, Sooyeon Kwon, Juanda Leo Hartono, Nanne K. de Boer, Tariq Ahmad, Federico Guillermo Antillon‐Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E. J. Yeoh, Kjeld Schmiegelow, Jun J. Yang   +18 more
wiley   +1 more source

Improving the thermal stability of trans-epoxysuccinate hydrolase. [PDF]

J Zhejiang Univ Sci B
Bao W, Yao J, Pan H, Zhu R, Li X, Liao H.   +5 more
europepmc   +1 more source

Selective Modification of the Product Profile of Biocatalytic Hydrolyzed PET via Product‐Specific Medium Engineering

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The product profile of enzymatically hydrolyzed PET can be modified by medium engineering and thereby adapted to a desired product. TPA, MHET or BHET can be forced as the predominant product using a basic pH (blue), 25 % ethylene glycol (EG) and IsPETasewt (green) or ≥25 % EG and LCCICCG (pink), respectively.
Tobias Heinks, Katrin Hofmann, Simon Last, Igor Gamm, Luise Blach, Ren Wei, Uwe T. Bornscheuer, Christof Hamel, Jan von Langermann   +8 more
wiley   +1 more source

Virulence factors, biofilm formation and antifungal resistance in Candida albicans from recurrent vulvovaginal candidiasis patients: a comparative study. [PDF]

Sci Rep
Yan C, Zhang J, Yang Y, Zeng X, Xiao G.
europepmc   +1 more source

Covalent Immobilization of Laccase on Mesoporous Bismuth Silicate for High‐Performance Biodegradation of Contaminants

European Journal of Inorganic Chemistry, EarlyView.
Myceliophthora thermophila laccase covalently immobilized on bismuth silicate (BiSi‐ext) achieved synergistic adsorption–biodegradation of Tectilon Blue 4R‐01 and ibuprofen. The biocatalyst showed enhanced stability, reusability, and rapid pollutant removal via expanded active‐site accessibility, enabling efficient, eco‐friendly wastewater remediation.
Erick Paiva Cancella, Guilherme de Paula Guarnieri, Yuriy B. Lipisa, Fábio Rogério de Moraes, Adriano de Vasconcellos, Giselle Maria Maciel, José Geraldo Nery   +6 more
wiley   +1 more source

Commentary: CVM-1118 (foslinanib), a 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1. [PDF]

Pathol Oncol Res
Hendrix MJC, Seftor EA, Seftor REB, Chu YW, Chien DS, Chen YL.   +5 more
europepmc   +1 more source