Results 191 to 200 of about 151,216 (363)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Role of the pneumococcal autolysin (murein hydrolase) in the release of progeny bacteriophage and in the bacteriophage-induced lysis of the host cells [PDF]

, 1977
C Ronda-Laín, Rafael López Núñez, A.Ma García Tapia, Alexander Tomasz   +3 more
openalex   +1 more source

Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense

ChemBioChem, EarlyView.
Lienhwalides are novel tropolone–maleidride hybrid molecules unique in nature. Absolute configuration is solved by semisynthetic approaches and X‐ray analysis. Interplay between both lwt and lwm biosynthetic gene clusters is responsible for the production of lienhwalides.
Katharina Schmidt, Esteban Charria‐Girón, Tatiana E. Gorelik, Christian Kleeberg, Jackson M. Muema, Simone Heitkämper, Bart Verwaaijen, Eric Kuhnert, Jennifer Gerke, Jörn Kalinowski, Kevin D. Hyde, Marc Stadler, Russell Cox, Frank Surup   +13 more
wiley   +1 more source

Biocatalytic recycling of plastics: facts and fiction. [PDF]

Chem Sci
Zimmermann W.
europepmc   +1 more source

Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases

ChemBioChem, EarlyView.
Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
wiley   +1 more source

Dietary fiber chemical structure determined gut microbiota dynamics

iMeta, Volume 1, Issue 4, December 2022., 2022
The monosaccharide composition and glycosidic bond configuration determine the CAZyme that could hydrolyze it. Thus, bacteria encoding specific CAZyme utilize different structured dietary fibers. Compounded with bacterial interaction, gut microbiota dynamics is synergistically modulated.
Xin Meng, Jun Zheng, Fengqiao Wang, Jie Zheng, Dong Yang   +4 more
wiley   +1 more source

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression. [PDF]

J Headache Pain
Brugia F, Ivanov K, Aroviita A, Giniatullina R, Lehtonen M, Malm T, Savinainen J, Giniatullin R, Della Pietra A.   +8 more
europepmc   +1 more source

Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease [PDF]

, 1970
Adrian P. Douglas, T. J. Peters
openalex   +1 more source

Biochemical Characterization of Multimodular Xylanolytic Carbohydrate Esterases from the Marine Bacterium Flavimarina sp. Hel_I_48

ChemBioChem, EarlyView.
Multimodular carbohydrate‐active enzymes often combine different catalytic activities for efficient polysaccharide degradation. In this work, the structural and functional characterization of three multimodular xylan‐targeting esterases, Fl6, Fll1 and Fll4 from Flavimarina sp. Hel_I_48, are presented.
Michelle Teune, Thorben Döhler, Daniel Bartosik, Thomas Schweder, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
This review discusses dynamically responsive self‐assembling peptide‐based nano‐drug systems, including the stimulation response, strategy of biomimicry, subcellular internalization, and the applications of peptide nano‐drug materials, and concludes with a brief outlook of their challenges and opportunities in clinical translation.
Yuhan Wang, Jie Zhan, Jinyan Huang, Xing Wang, Zehong Chen, Zhimou Yang, Jie Li   +6 more
wiley   +1 more source