Results 221 to 230 of about 100,330 (296)

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1. [PDF]

FEBS Lett
Nakatsuji T, Shiraishi K, Wang C, Yurimoto H, Sakai Y, Oku M.   +5 more
europepmc   +1 more source

Tumor Cell Migration May Be an Inherent “Foraging” Behavior

Medicine Advances, EarlyView.
Tumor cells gradually form pseudopodia, migrate to necrotic cells, make contact with them, and absorb necrotic cell debris. During this migration, small vesicles formed by dying tumor cells also gradually migrate toward living tumor cells. Once the nutrients from the necrotic cells have been completely absorbed, the living tumor cells will leave ...
Fuqian Zhao, Hongmei Niu, Lusi Zhang, Daofu Shen, Lei Wang   +4 more
wiley   +1 more source

Comparative genomics of aflatoxigenic A. flavus reveals mycotoxin diversity and postharvest adaptation in cashew nuts from coastal Kenya. [PDF]

Sci Rep
Katua K, Kitundu GL, Gachanja PW, Musangi CR, Juma BS, Mukhebi DW, Kibiti CM, Swaleh S, Mbinda WM.   +8 more
europepmc   +1 more source

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins

, 2016
Matthew Jenner, José P. Afonso, Christoph Kohlhaas, Petra Karbaum, Sarah Frank, Jörn Piel, Neil J. Oldham   +6 more
openalex   +2 more sources

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Cloning and Characterization of the Novel Endoglucanase Identified in Deep Subsurface Thermal Well of Biragzang (North Ossetia) by Metagenomic Analysis. [PDF]

Biomolecules
Trachtmann NV, Toshchakov SV, Izotova AO, Korzhenkov AA, Evteeva MA, Kachmazov GS, Agboigba EE, Validov SZ.   +7 more
europepmc   +1 more source

D‐Optimal Design for Enzymatic Ring‐Opening Polymerization of ε‐Caprolactone: Toward Sustainable Polyester Synthesis Using Biobased Solvents

Journal of Polymer Science, EarlyView.
A D‐optimal design of experiments maps the influence of key reaction parameters on enzymatic ε‐caprolactone polymerization. Thus linking multivariate conditions to conversion, molar mass characteristics, and by‐product formation, whilst demonstrating that biobased solvents offer viable, sustainable media for polyester synthesis.
Emily G. Dixon, Emily Chau, Luisa Ciano, Anca Pordea, Karen Alvey, Vincenzo Taresco   +5 more
wiley   +1 more source

Analysis of NUDIX enzymes across fungi reveals previously unrecognized diversity. [PDF]

BMC Genomics
Pasterny Z, Barua D, Mancera E, Muszewska A.   +3 more
europepmc   +1 more source

Novel applications of the tomato microbiome: Roles and considerations for agriculture, human health, and society

PLANTS, PEOPLE, PLANET, EarlyView.
Plants, like humans, have a microbiome that helps them grow, defend themselves against pathogens, acquire nutrients, and protect themselves against environmental stresses. The microbiome of tomatoes, a staple crop grown worldwide, could be utilized not only to reduce fertilizer and pesticide applications, but also to clean up harmful pollutants ...
Sean Lindert, Kathryn Kingsley, Peerapol Chiaranunt, James F. White   +3 more
wiley   +1 more source