Results 231 to 240 of about 100,330 (296)

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

Cell wall mechanical stress could coordinate septal synthesis and scission in <i>Staphylococcus aureus</i>. [PDF]

mBio
Hoshyaripour S, Mauri M, Hobbs JK, Foster SJ, Allen RJ.   +4 more
europepmc   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Characterization of hydrolase activity in ocular tissues of humans and preclinical species. [PDF]

Drug Metab Dispos
Li M, Zhang D, Jones RS, Cheruzel L, Khojasteh SC, Chen HH, Adaligil E, Shwani T, Owen LA, Kim IK, DeAngelis MM, Ma B.   +11 more
europepmc   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Draft genome sequence of <i>Nitratireductor</i> sp. PBL-C9-a marine bacterium encoding glycoside hydrolases isolated from Batu Laut Beach in Selangor, Malaysia. [PDF]

Microbiol Resour Announc
Kahar UM, Abdul Rahman N, Sharoul NA, Muhammad Ramzan F.   +3 more
europepmc   +1 more source

Chemical Characterization of Postindustrial Recycled Polyethylene Terephthalate Obtained From Multilayer PET/PE Sheets: A Baseline Study on Safety Aspects

Packaging Technology and Science, EarlyView.
PET trays pose recycling challenges due to multilayer structures with polyethylene (PE) tie‐layers and barrier materials. In this study, a delamination process using a hot alkaline solution was applied to postindustrial multilayer PET/PE thermoforming waste to recover PET flakes and produce sheets.
Isabela F. A. Daras, Srishti Singh, Tiago Vieira, Joel Pereira, Patrícia Guerreiro, Clara Sousa, Fátima Poças   +6 more
wiley   +1 more source

Characterization of an isobutylene epoxide hydrolase (IbcK) from the isobutylene-catabolizing bacterium <i>Mycolicibacterium</i> sp. ELW1. [PDF]

Appl Environ Microbiol
Faulkner NW, Joyce JB, Smith C, Swartz P, Rose RB, Miller ES, Hyman MR.   +6 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae. [PDF]

Nat Commun
Balaska S, Grigoraki L, Lycett G, Weetman D, Oladepo F, Colman F, Vontas J, Paine MJI, Ismail HM.   +8 more
europepmc   +1 more source