Biotechnological Approach for the Production of Enantiomeric Hydroxylactones Derived from Benzaldehyde and Evaluation of Their Cytotoxic Activity [PDF]
, 2020 The β-aryl-δ-halo-γ-lactones are known for their antiproliferative activity towards numerous cancer cell lines. The aim of this study was to obtain in the biotransformation process new β-aryl-δ-hydroxy-γ-lactones and ...
Witold Gładkowski +5 more
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Chemistry – A European Journal, Volume 30, Issue 50, September 5, 2024.A novel method is presented, demonstrating the facile generation of α‐acyloxy carboxamide radicals via photoredox catalysis of Passerini adducts, obtained employing a 4‐formyl‐1,4‐dihydropyridine. These radicals efficiently undergo Giese reactions with various olefins, yielding novel Passerini compounds unattainable through traditional aldehyde‐based ...
Francesca Brunelli +5 more
wiley +1 more source
Advances Toward Amphidinolides C, F and U: Isolations, Synthetic Studies and Total Syntheses
Chemistry – A European Journal, Volume 30, Issue 27, May 14, 2024.Amphidinolides C, F and U are a sub‐class of polyketides sharing a similar structure, isolated from dinoflagellates or octocoral sponges and exhibiting high cytotoxic activity. This review discloses the progress made in their isolations and structural determinations and the various synthetic approaches and successful attempts leading to their total ...
Ismaila Ciss +3 more
wiley +1 more source
Meta‐omics assisted microbial gene and strain resources mining in contaminant environment
Engineering in Life Sciences, Volume 24, Issue 5, May 2024.Abstract Human activities have led to the release of various environmental pollutants, triggering ecological challenges. In situ, microbial communities in these contaminated environments are usually assumed to possess the potential capacity of pollutant degradation.
Yiqun Huang +5 more
wiley +1 more source
Reaction of cis-3-Chloroacrylic Acid Dehalogenase with an Allene Substrate, 2,3-Butadienoate: Hydration via an Enamine [PDF]
, 2016 cis-3-Chloroacrylic acid dehalogenase (cis-CaaD) catalyzes the hydrolytic dehalogenation of cis-3-haloacrylates to yield malonate semialdehyde. The enzyme processes other substrates including an allene (2,3-butadienoate) to produce acetoacetate.
Kenneth A. Johnson (519121) +5 more
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Reaction Mechanism of cis-3-Chloroacrylic Acid Dehalogenase : A Theoretical Study [PDF]
, 2009 The reaction mechanism of cis-3-chloroacrylic acid dehalogenase (cis-CaaD) is studied using the B3LYP density functional theory method. This enzyme catalyzes the hydrolytic dehalogenation of cis-3-chloroacrylic acid to yield malonate semialdehyde and HCl.
Sevastik, Robin, +3 more
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Reagent Engineering for Group Transfer Biocatalysis
Angewandte Chemie, Volume 136, Issue 7, February 12, 2024.Biocatalytic group transfer reactions can efficiently generate highly complex molecules under mild and environmentally friendly conditions. This Minireview highlights inspiring examples of the development of non‐natural donor reagents to power such enzymatic transformations, while discussing the design aspects behind the choice of reagent.
John H. Reed, Florian P. Seebeck
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The mechanistic role of catalytic residues in non-stereo dehalogenase (DehE) [PDF]
, 2016 Introduction: DehE or non-stereospecific dehalogenase from Rhizobium sp. RC1 catalyzes the hydrolytic dehalogenation of both isomers of D,L-2-haloacids to produce an inverted configuration of 2-hydroxyl acid.
Abdul Hamid, Azzmer Azzar +1 more
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Interactions of non-natural halogenated substrates with D-specific dehalogenase (DehD) mutants using in silico studies [PDF]
, 2014 The D-2-haloacid dehalogenase of D-specific dehalogenase (DehD) from Rhizobium sp. RC1 catalyses the hydrolytic dehalogenation of D-haloalkanoic acids, inverting the substrate-product configuration and thereby forming the corresponding L-hydroxyalkanoic ...
Jamaluddin, Haryati +4 more
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The 21-dehydroxglation of corticosteroids of Eubacterium lentum and the dehalogenation of 4-chlorobenzoic acid by 4-chlorobenzoate dehalogenase [PDF]
, 1988 Two enzyme mechanisms were investigated: the 21-dehydroxylation of corticosteroids by Eubacterium lentum and the dehalogenation of 4-chlorobenzoic acid by Pseudomonas sp. CBS 3.
Ninniss, Ronald William.
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