Results 71 to 80 of about 22,566 (251)

The marine sponge genus Dysidea sp: the biological and chemical aspects—a review

Future Journal of Pharmaceutical Sciences, 2023
Background Marine sponges and other marine invertebrates are considered hidden treasures for a variety of secondary metabolites with pharmacognostic and pharmacological activities which have the potential to create future “super drugs.” The main body of ...
Noha Fathallah, Ahmed Tamer, Reem Ibrahim, Mariam kamal, Mariam El Kes   +4 more
doaj   +1 more source

Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi. [PDF]

, 2019
Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood.
Ahrendt, Steven, Blanchette, Robert A, Cullen, Daniel, Gaskell, Jill, Grigoriev, Igor V, Hibbett, David S, Master, Emma, Schilling, Jonathan S, Toapanta, Christina, Wu, Baojun, Zhang, Jiwei   +10 more
core   +1 more source

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure [PDF]

, 2013
Toxicity screening of compounds provides a means to identify compounds harmful for human health and the environment. Here, we further develop the technique of genomic phenotyping to improve throughput while maintaining specificity.
AB Parsons, AM Smith, AM Smith, AP Gasch, BE Bauer, CB Bennett, CH Ho, D Fu, D Fu, D Gresham, G Giaever, GH Braus, H Abdoul-Carime, H Gorner, H Ischiropoulos, J Heitman, J. Peter Svensson, K Brombacher, K Umebayashi, Laia Quirós Pesudo, Leona D. Samson, LJ Marnett, LK Palmer, M Alia, M Chang, M Valko, Martin G. Marinus, MB Eisen, ME Hillenmeyer, P Fowler, P Ross-Macdonald, P Shannon, Paul Carmichael, PL Gutierrez, SE Pierce, Siobhan K. McRee, TJ Begley, TJ Begley, TM Penning, V Sosa, XJ He, Y Song, Yeyejide Adeleye, YV Vasil’ev   +43 more
core   +3 more sources

Structural, Spectroscopic, and Electrochemical Properties of Nonheme Fe(II)-Hydroquinonate Complexes: Synthetic Models of Hydroquinone Dioxygenases [PDF]

, 2012
Using the tris(3,5-diphenylpyrazol-1-yl)borate (Ph2Tp) supporting ligand, a series of mono- and dinuclear ferrous complexes containing hydroquinonate (HQate) ligands have been prepared and structurally characterized with X-ray crystallography.
Baum, Amanda E., Fiedler, Adam T., Lindeman, Sergey, Park, Heaweon, Wang, Denan   +4 more
core   +2 more sources

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Redox Chemistry of Ca-Transporter 2-Palmitoylhydroquinone in an Artificial Thin Organic Film Membrane [PDF]

, 2007
The redox chemistry of 2-palmitoylhydroquinone (H2Q), a recently introduced synthetic transmembrane Ca2+ transporter, was studied with cyclic and square-wave voltammetry in an artificial thin organic-film membrane sandwiched between a pyrolytic ...
Mirceski, Valentin, Gulaboski, Rubin, Bogeski, Ivan, Hoth, Markus   +3 more
core   +1 more source

Synergistic Enhancement of Antioxidant Activity in Arbutus unedo Leaf Extract by Biological Fluids: Implications for Functional and Nutraceutical Applications

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT This study examined the effect of biological fluids (saliva, blood plasma, and urine) on the antioxidant capacity of an aqueous extract derived from Arbutus unedo leaves. The extract displayed a concentration‐dependent reducing activity in the ferric reducing power assay (IC50 = 292 ± 7.54 µg/mL) and phosphomolybdenum assays (IC50 = 461.67 ± 4.
Idir Moualek, Hamdi Bendif, Karima Benarab, Giulio Lupidi, Fehmi Boufahja, Stefania Garzoli, Karim Houali   +6 more
wiley   +1 more source

Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome [PDF]

, 2017
Intestinal helminth infections occur pre dominantly in regions where exposure to enteric bacterial pathogens is also common. Helminth infections inhibit host immunity against microbial pathogens, which has largely been attributed to the induction of ...
Borchers, Christoph H., Brosschot, Tara P., Brown, Eric M., Finlay, B. Brett, Gill, Navkiran, Han, Jun, Marshall, Natalie C., Perona-Wright, Georgia, Redpath, Stephen A., Reynolds, Lisa A., Valdez, Yanet, van der Heijden, Joris, Woodward, Sarah E., Yurist-Doutsch, Sophie   +13 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Determination of Hydroquinone Dioxygenase Activity

Bio-Protocol, 2015
We recently demonstrated the presence of a quinone detoxification pathway present in Firmicutes. It is based on two enzyme activities, namely a hydroquinone dioxygenase, YaiA, described here, and a hydroquinone reductase, YaiB, described in a separate ...
Stefano Mancini, Marc Solioz
doaj   +1 more source