Hydroxocobalamin Dosing Strategies for Vasoplegic Syndrome Post-cardiac Surgery: A Retrospective Cohort Study. [PDF]
CureusIntroduction: Vasoplegic syndrome is a common complication following cardiac surgery, characterized by profound hypotension and high vasopressor requirements.
Behlers QB +4 more
europepmc +3 more sources
Vitamin B12 (hydroxocobalamin) administration in the management of persistent vasoplegic shock. [PDF]
Saudi J AnaesthVasoplegia, characterized by low systemic vascular resistance despite normal to high cardiac output, can result from various conditions, including cardiac surgery, and progress to vasoplegic shock if untreated.
Ikram J +4 more
europepmc +3 more sources
579 Incidence of Acute Kidney Injury with Hydroxocobalamin Administration [PDF]
J Burn Care ResIntroduction Hydroxocobalamin is frequently administered to patients with inhalation injuries. Recent literature has raised concerns about its potential association with an increased risk of acute kidney injury (AKI).
Adalah Yahia +3 more
europepmc +3 more sources
Blood, 1966 Abstract The mean hepatic biological half-life of Co57-hydroxocobalamin injected to 5 normal human subjects was similar to that of Co60-cyanocobalamin, as shown by double-label hepatic surface counting during the first 30 weeks after intramuscular or intravenous injection of cobalamins. In 2 cases in whom the counting was extended over a
George B. Jerzy Glass +2 more
+9 more sources
Hydroxocobalamin as Rescue Therapy in a Patient With Refractory Amlodipine-Induced Vasoplegia [PDF]
Cureus, 2023 Vasoplegic syndrome is a type of distributive shock characterized by mean arterial pressure of less than 65 mmHg, with normal to high cardiac output and often refractory to fluid resuscitation, high doses of intravenous vasopressors, and inotropes. It is
Laith A Ayasa +8 more
openalex +2 more sources
The Durability of Intravenous Hydroxocobalamin in Vasoplegia
Cureus, 2023 Objectives Refractory distributive shock (vasoplegia) has been treated with intravenous (IV) hydroxocobalamin (B12), but its use is poorly characterized.
Madeline Blaha, M. Blais, Logan M. Olson
semanticscholar +3 more sources
Late-onset refractory hemolytic anemia in siblings treated for methionine synthase reductase deficiency: A rare complication possibly prevented by hydroxocobalamin dose escalation? [PDF]
JIMD RepMethionine synthase reductase deficiency (cblE) is a rare autosomal recessive inborn error of cobalamin metabolism caused by pathogenic variants in the methionine synthase reductase gene (MTRR).
Nguyen A +7 more
europepmc +2 more sources
511 Hydroxocobalamin Not the Clear Culprit of Nephrotoxicity After Cyanide Poisoning [PDF]
J Burn Care ResIntroduction Inhalation injury (IHI) and cyanide poisoning are often observed in burn patients, but they may also present without cutaneous injury. If cyanide toxicity is suspected, the antidote, hydroxocobalamin, is indicated. Although a lifesaving drug,
Elise M Mann +8 more
europepmc +2 more sources
Sensitivity to cyanocobalamin and hydroxocobalamin. [PDF]
BMJ, 1971 Jennifer James, R. P. Warin
openalex +5 more sources
Hemodynamic Effects of Hydroxocobalamin in Conscious Dogs [PDF]
Anesthesiology, 1991 Hydroxocobalamin has been shown to be a rapid and powerful antidote in acute cyanide poisoning and to prevent cyanide poisoning during sodium nitroprusside administration. However, its hemodynamic effects remain unknown. The authors therefore investigated the effects in chronically instrumented conscious dogs (n = 8) that were randomly given ...
Bruno Riou +5 more
openalex +4 more sources