Results 61 to 70 of about 7,346 (216)
Biosynthesis of the Biphenomycin Family of Potent Antibiotics
Angewandte Chemie International Edition, Volume 64, Issue 51, December 15, 2025.The complete biosynthetic pathway of the biphenomycin antibiotics is elucidated, revealing a unique enzymatic machinery featuring a bifunctional MNIO, a regioselective arginase, a B12‐dependent rSAM for C,C coupling, hydroxylation enzymology, and a metalloprotease with dual‐specificity.
Elisabeth Strunk +7 more
wiley +1 more source
Case Report: Membranous Nephropathy Secondary to Cobalamin C Disease
Frontiers in Medicine, 2022 BackgroundMutation of MMACHC causes inherited cobalamin C disease with methylmalonic academia (MMA) and homocysteinemia. Renal complications may also be present in patients with this deficiency.
Qiang Wang +5 more
doaj +1 more source
The Explanatory Indispensability of Memory Traces [PDF]
, 2020 During the first half of the twentieth century, many philosophers of memory opposed the postulation of memory traces based on the claim that a satisfactory account of remembering need not include references to causal processes involved in recollection ...
De Brigard, Felipe
core
Gene identification for the cblD defect of vitamin B12 metabolism [PDF]
, 2008 Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the ...
Baumgartner, M R +7 more
core +1 more source
Not all that is red is blood: a curious case of chromaturia
Clinical Case Reports, 2018 Key Clinical Message Hydroxocobalamin causes reddish discoloration of the urine, mimicking hematuria. Clinicians should be aware of this common side effect of the rarely used drug to prevent unnecessary consultations and work‐up. Additional benign causes
Abhilash Koratala +2 more
doaj +1 more source
ChemCatChem, Volume 17, Issue 21, November 10, 2025.Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2613-2620, September 2025.Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Betty S. H. Chan +3 more
wiley +1 more source
JIMD ReportsMethionine synthase reductase deficiency (cblE) is a rare autosomal recessive inborn error of cobalamin metabolism caused by pathogenic variants in the methionine synthase reductase gene (MTRR).
Alexandre Nguyen +7 more
doaj +1 more source
BMC Pediatrics, 2021 Background Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin.
Katarína Brennerová +6 more
doaj +1 more source
Methodist DeBakey Cardiovascular Journal, 2023 Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure,
Iqbal Ratnani +3 more
doaj +1 more source