Results 61 to 70 of about 8,578 (226)
Causes of and diagnostic approach to methylmalonic acidurias [PDF]
, 2018 Summary: Several mutant genetic classes that cause isolated methylmalonic acidurias (MMAuria) are known based on biochemical, enzymatic and genetic complementation analysis. The mut0 and mut− defects result from deficiency of MMCoA mutase apoenzyme which
Baumgartner, M., Fowler, B., Leonard, J.
core
An integrated perspective on RNA aptamer ligand-recognition models : clearing muddy waters [PDF]
, 2017 Riboswitches are short RNA motifs that sensitively and selectively bind cognate ligands to modulate gene expression. Like protein receptor-ligand pairs, their binding dynamics are traditionally categorized as following one of two paradigmatic mechanisms:
McCluskey, K., Penedo, J. Carlos
core +1 more source
Microbial demethylation of dimethylsulfoniopropionate and methylthiopropionate [PDF]
, 2000 As discussed in chapter 1 , there is an increased interest in the production of certain natural sulfur-containing flavor compounds or flavor precursors.
Jansen, Michael,
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Nasal absorption of hydroxocobalamin in healthy elderly adults [PDF]
British Journal of Clinical Pharmacology, 1998 Aims To investigate the nasal absorption of hydroxocobalamin in 10 healthy elderly adults. Methods In a cross‐over study, blood samples were collected before administration of the drug and after 10, 20, 30, 40, 60, 120, 180 and 240 min.
Asselt, D.Z.B. van +3 more
openaire +4 more sources
Emergency Management of Intoxication‐Type Inherited Metabolic Disorders
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT In many intoxication‐type inherited metabolic disorders, the accumulation of the toxic chemical can cause acute life‐threatening emergencies. Sometimes this is the inevitable consequence of a severe metabolic defect, but it is often triggered by catabolism.
J. Dexter Tarr, Andrew A. M. Morris
wiley +1 more source
Potassium channel‐mediated NO‐induced vasodilation during maturation: Dominance of Kv7 channels
FASEB BioAdvances, Volume 7, Issue 3, March 2025.Scheme illustrating the key findings: Potassium channels, even multiple ones, contribute to SNP‐induced vasorelaxation in young and adult rats and these channels change from Kv1 and Kv7 channels to BKCa and Kv7 channels during postnatal development.
Anastasia A. Shvetsova +4 more
wiley +1 more source
Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo [PDF]
, 2014 This is the peer reviewed version of the article, which has been published in final form at [doi: 10.1111/jth.12711. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.Nitric oxide (NO ...
Apostoli, GL +4 more
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SignatureFinder enables sequence mining to identify cobalamin‐dependent photoreceptor proteins
The FEBS Journal, Volume 292, Issue 3, Page 635-652, February 2025.The authors show the utility of their computational tool, available at https://enzymeevolver.com, for the identification of novel photoreceptors. Signature residues for the binding of the green‐light‐sensitive cofactor adenosylcobalamin were determined.
Yuqi Yu +10 more
wiley +1 more source
Drug-therapy networks and the predictions of novel drug targets [PDF]
, 2008 Recently, a number of drug-therapy, disease, drug, and drug-target networks have been introduced. Here we suggest novel methods for network-based prediction of novel drug targets and for improvement of drug efficiency by analysing the effects of drugs on
Csermely, Peter +2 more
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JIMD Reports, Volume 66, Issue 1, January 2025.Abstract Background Classic homocystinuria (HCU) is a rare inborn metabolic disease that is generally asymptomatic at birth. If untreated, it can cause a wide range of complications including intellectual disability, lens dislocation, and thromboembolism.
Ahmed Sarar Mohamed +5 more
wiley +1 more source