Results 131 to 140 of about 5,706 (177)
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985
Human umbilical arteries convert arachidonic acid into three hydroxy-eicosatetraenoic acids as well as 6-ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and D2 and thromboxane B2. Two of these hydroxy derivatives of arachidonic acid were purified by reverse-phase HPLC and identified by GC-MS as 11-hydroxyeicosatetraenoic acid (11-HETE) and 15 ...
B N, Setty, M J, Stuart, R W, Walenga
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Human umbilical arteries convert arachidonic acid into three hydroxy-eicosatetraenoic acids as well as 6-ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and D2 and thromboxane B2. Two of these hydroxy derivatives of arachidonic acid were purified by reverse-phase HPLC and identified by GC-MS as 11-hydroxyeicosatetraenoic acid (11-HETE) and 15 ...
B N, Setty, M J, Stuart, R W, Walenga
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Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension
Current Opinion in Nephrology and Hypertension, 2004Cytochrome P-450 metabolites of arachidonic acid have been reported to play an important role in the control of renal function and vascular tone, and in the long-term control of arterial pressure. In this regard, 20-hydroxyeicosatetraenoic acid is a potent vasoconstrictor that inhibits sodium reabsorption in the kidney.
Albert, Sarkis +2 more
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20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure
Current Opinion in Nephrology and Hypertension, 2001The properties of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids, vasoactivity and modulation of ion transport and mediation/modulation of the effects of vasoactive hormones, such as angiotensin II and endothelin, underscore their importance to renal vascular mechanisms and electrolyte excretion.
J C, McGiff, J, Quilley
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The development of a radioimmunoassay for 12-L-hydroxyeicosatetraenoic acid
Prostaglandins, 1980Antibodies directed toward 12-L-hydroxyeicosatetraenoic acid (12-L-HETE) were generated in rabbits by immunization with conjugates of 12-L-HETE and human serum albumin. The concentration of antibodies was determined by incubating immune plasma with 12-L-HETE that had been covalently linked to a solid support, washing the 12-L-HETE support, and ...
L, Levine +4 more
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Brain Microvessels Produce 12‐Hydroxyeicosatetraenoic Acid
Journal of Neurochemistry, 1989Abstract: Cerebral microvessels isolated from perfused, adult murine brain produce a compound with the chromatographic properties of a monohydroxyeicosatetraenoic acid when incubated with arachidonic acid or stimulated with calcium ionophore A23187. The formation of this arachidonic acid metabolite is not reduced in the presence of the cyclooxy‐genase ...
S A, Moore +3 more
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Promotion of adipogenesis by 15-(S)-hydroxyeicosatetraenoic acid
Prostaglandins & Other Lipid Mediators, 2016Excess adipogenesis is a characteristic of obesity, which is associated with serious health problem, including type 2 diabetes. Here, to better understand the mechanisms for the development of adipocytes, we investigated the regulatory role of 15-(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in adipogenesis by treating 3T3-L1 murine preadipocytes and ...
Yong-Seok, Song +5 more
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Drug Metabolism Reviews, 2023
The phenomenon of chirality has been shown to greatly impact drug activities and effects. Different enantiomers may exhibit different effects in a certain biological condition or disease state. Cytochrome P450 (CYP) enzymes metabolize arachidonic acid (AA) into a large variety of metabolites with a wide range of activities.
Sara A. Helal +2 more
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The phenomenon of chirality has been shown to greatly impact drug activities and effects. Different enantiomers may exhibit different effects in a certain biological condition or disease state. Cytochrome P450 (CYP) enzymes metabolize arachidonic acid (AA) into a large variety of metabolites with a wide range of activities.
Sara A. Helal +2 more
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Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid
Current Opinion in Nephrology and Hypertension, 201620-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid and a key constituent of the microcirculation. Its effects on vascular function are multifaceted and include stimulation of smooth muscle, contractility, migration, and proliferation, as well as endothelial cell dysfunction and inflammation.
Victor, Garcia, Michal L, Schwartzman
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Inhibition of Adenylyl Cyclases by 12(S)-Hydroxyeicosatetraenoic Acid
Biochemical and Biophysical Research Communications, 1996The inhibition of adenylyl cyclase (AC) by a 12-lipoxygenase metabolite of arachidonic acid, 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE), was investigated using three different kinds of cells: NRK-49F (normal rat kidney fibroblasts), AtT-20 (mouse pituitary tumor cell line) and HL-60 (human leukemia cells) cells. The inhibition was very
X.-Q. Wang +5 more
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Synthesis of 12-hydroxyeicosatetraenoic acid by human endometrium and decidua
Prostaglandins, Leukotrienes and Essential Fatty Acids, 1993In order to clarify the possible involvement of lipoxygenase metabolites of arachidonic acid (AA) in implantation, monohydroxylic acid production was examined using human endometrium and decidua in early pregnancy. As 14C-AA was mainly converted to 12-hydroxyeicosatetraenoic acid (12-HETE) as well as prostaglandins (PGs) by the microsomal fraction of ...
Y, Ihno, O, Ishihara, K, Kinoshita
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