Results 141 to 150 of about 5,706 (177)
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20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis
American Journal of Physiology-Heart and Circulatory Physiology, 2015Endothelial cells play an important role in the process of coagulation and the function of platelets. We have previously reported that 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid, increased platelet aggregation and induced hemostasis. The purpose of the present study is to investigate whether 20-HETE-mediated endothelial
Jiaxing, Wang +10 more
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Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors
International Journal of Cancer, 1985AbstractThe metabolism of arachidonic acid was investigated by radioimmunoassay and chromatographic techniques in 5 sarcomas and one embryonal carcinoma of human origin maintained as transplantable tumors in nude mice. The results obtained indicate that: (1) the absolute quantities of arachidonic acid metabolites produced by a given tumor varied ...
R A, Knazek, C L, Yee, J, Costa
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Biochemistry, 1988
Cultured endothelial cells take up 15-hydroxyeicosatetraenoic acid (15-HETE), a lipoxygenase product formed from arachidonic acid, and incorporate it into cellular phospholipids and glycerides. Uptake can occur from either the apical or basolateral surface.
X Y, Shen +3 more
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Cultured endothelial cells take up 15-hydroxyeicosatetraenoic acid (15-HETE), a lipoxygenase product formed from arachidonic acid, and incorporate it into cellular phospholipids and glycerides. Uptake can occur from either the apical or basolateral surface.
X Y, Shen +3 more
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Prostaglandins, Leukotrienes and Medicine, 1984
The interaction of proliferating macrophages with the glomerulus may play an important role in certain forms of glomerulonephritis. This interaction could involve metabolites of arachidonic acid (C20:4) such as prostaglandins (PG) and lipoxygenase products.
J, Sraer +6 more
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The interaction of proliferating macrophages with the glomerulus may play an important role in certain forms of glomerulonephritis. This interaction could involve metabolites of arachidonic acid (C20:4) such as prostaglandins (PG) and lipoxygenase products.
J, Sraer +6 more
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Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid
Molecular and Biochemical Parasitology, 1996Hemozoin, a heme byproduct of hemoglobin digestion by malaria parasites, is released into the blood stream of the host upon lysing of infected erythrocytes. Since heme-compounds are potent catalysts of lipid peroxidation, we evaluated the catalytic ability of Plasmodium falciparum-derived hemozoin to oxidize arachidonic acid to hydroxyeicosatetraenoic ...
M D, Green, L, Xiao, A A, Lal
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Biological Mass Spectrometry, 1988
A direct mass spectrometric method for 15-hydroxy metabolites of arachidonic acid and of eicosapentaenoic acid is described. 15-Hydroxyeicosanoids have the capacity to inhibit the formation of leukotrienes, potent mediators of inflammation formed by the 5-lipoxygenase pathway of arachidonic acid metabolism and may therefore have anti-inflammatory ...
K, Fogh +4 more
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A direct mass spectrometric method for 15-hydroxy metabolites of arachidonic acid and of eicosapentaenoic acid is described. 15-Hydroxyeicosanoids have the capacity to inhibit the formation of leukotrienes, potent mediators of inflammation formed by the 5-lipoxygenase pathway of arachidonic acid metabolism and may therefore have anti-inflammatory ...
K, Fogh +4 more
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A practical enantioselective synthesis of 12-hydroxyeicosatetraenoic acids
Tetrahedron Letters, 1988Abstract A practical enantioselective synthesis of 12(R)-HETE has been achieved from readily available starting materials. This process also constitutes a formal synthesis of Leukotriene B 4 .
Stevan W Djurić +2 more
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Renin Response to 12-Hydroxyeicosatetraenoic Acid Is Increased in Diabetic Rats
Diabetes, 1995Eicosanoids (prostaglandins) can alter renin secretion and angiotensin (ANG) II action. We have studied the effects of both prostacyclin and a lipoxygenase (LO) product, 12-hydroxyeicosatetraenoic acid (12-HETE), on renin in normal and streptozotocin-induced diabetic rats.
I, Antonipillai +4 more
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Biosynthesis of hydroxyeicosatetraenoic acids (HETEs) in marine and freshwater hydroids
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19931. Whole homogenates from six hydroid species, the marine Eudendrium rameum, Eudendrium racemosum, Sertularella sp., Halocordyle disticha and Aglaophenia pluma, and the freshwater Hydra oligactis were screened for their capability of synthesizing hydroxyeicosatetraenoic acids (HETEs) from exogenously added arachidonic acid (AA). 2. Only the homogenates
Di Marzo V +5 more
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Photodermatology, photoimmunology & photomedicine, 1992
To reveal the underlying mechanisms in the therapeutic effectiveness of ultraviolet (UBV)- and psoralen plus UVA phototherapy, the photostability of leukotriene B4 (LTB4), 12-hydroxyeicosatetraenoic acid (12-HETE) and 5-HETE was investigated in the presence and absence of photosensitizers (8-methoxypsoralen and 5-methoxypsoralen).
B, Lehmann, A, Kämpf, J, Barth
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To reveal the underlying mechanisms in the therapeutic effectiveness of ultraviolet (UBV)- and psoralen plus UVA phototherapy, the photostability of leukotriene B4 (LTB4), 12-hydroxyeicosatetraenoic acid (12-HETE) and 5-HETE was investigated in the presence and absence of photosensitizers (8-methoxypsoralen and 5-methoxypsoralen).
B, Lehmann, A, Kämpf, J, Barth
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