Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]
, 2017 Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P +11 more
core +1 more source
Bioorganic & Medicinal Chemistry Letters, 2019 19-Hydroxyeicosatetraenoic acid (19-HETE, 1), a metabolically and chemically labile cytochrome P450 eicosanoid, has diverse biological activities including antagonism of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE, 2). A SAR study was conducted to develop robust analogs of 1 with improved in vitro and in vivo efficacy.
Rambabu Dakarapu +9 more
openaire +3 more sources
Hemodialysis and erythrocyte epoxy fatty acids
Physiological Reports, 2020 Fatty acid products derived from cytochromes P450 (CYP) monooxygenase and lipoxygenase (LOX)/CYP ω/(ω‐1)‐hydroxylase pathways are a superclass of lipid mediators with potent bioactivities.
Benjamin Gollasch +6 more
doaj +1 more source
Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese[S]
Journal of Lipid Research, 2016 Alcohol- and obesity-related liver diseases often coexist. The hepatic lipidomics due to alcohol and obesity interaction is unknown. We characterized the hepatic lipidome due to 1) alcohol consumption in lean and obese mice and 2) obesity and alcohol ...
Puneet Puri +10 more
doaj +1 more source
20-Hydroxyeicosatetraenoic Acid and Angiotensin [PDF]
Hypertension, 2010 Arachidonic acid metabolites generated by cytochrome P450 (CYP) enzymes are now recognized as contributing importantly to vascular function and blood pressure regulation.1 CYP4A enzymes act as hydroxylases converting arachidonic acid to hydroxyeicosatetraenoic acids (HETEs), with 20-HETE being the major product.
openaire +1 more source
Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]
, 2016 Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana +12 more
core +2 more sources
G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes. [PDF]
, 2017 Background:Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA).
Agak, George W +10 more
core +1 more source
A single meal has the potential to alter brain oxylipin content. [PDF]
, 2020 Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as ...
Aung, HH +5 more
core +1 more source
Downregulated serum 14, 15-epoxyeicosatrienoic acid is associated with abdominal aortic calcification in patients with primary aldosteronism [PDF]
, 2018 Patients with primary aldosteronism (PA) have increased risk of target-organ damage, among which vascular calcification is an important indicator of cardiovascular mortality.
Gao, Jingwei +8 more
core +1 more source
Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function [PDF]
Prostaglandins & Other Lipid Mediators, 2013 The development of pharmacological, genetic, and biochemical tools have allowed for detailed studies to determine the contribution of cytochrome P450 (CYP) metabolites of arachidonic acid to renal microvascular function. Renal microvessels can generate CYP hydroxylase metabolites including 20-hydroxyeicosatetraenoic acid (20-HETE) and CYP epoxygenase ...
openaire +2 more sources