Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. [PDF]
, 2020 In the brain, approximately 90% of oxylipins are esterified to lipids. However, the significance of this esterification process is not known. In the present study, we (1) validated an aminopropyl solid phase extraction (SPE) method for separating ...
Bazinet, Richard P +7 more
core +1 more source
Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. [PDF]
, 2018 The symposium, "Role of Nutrition in Alcoholic Liver Disease", was held at the European Society for Biomedical Research on Alcoholism Congress on 9 October 2017 in Crete, Greece. The goal of the symposium was to highlight recent advances and developments
Feldstein, Ariel E +8 more
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Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. [PDF]
, 2017 Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD.Serum from healthy ...
Erle, David J +11 more
core +1 more source
Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat
Journal of Lipid Research, 2007 We previously established that proteinuria alters the apolipoprotein content of lipoproteins. This study was conducted to establish whether proteinuria also alters the concentrations of oxidized lipids within lipoprotein density fractions.
John W. Newman +3 more
doaj +1 more source
Race‐based and sex‐based differences in bioactive lipid mediators after myocardial infarction
ESC Heart Failure, 2020 Aims Leucocyte‐directed specialized pro‐resolving mediators (SPMs) are essential for cardiac repair, and their biosynthesis coincides with the expression of pro‐inflammatory mediators; however, the precise quantitation during an acute myocardial ...
Ganesh V. Halade +6 more
doaj +1 more source
Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola[S]
Journal of Lipid Research, 2013 The metabolism of arachidonic acid (ARA) by cytochrome P450 ω/ω-1-hydroxylases leads to the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which is an important lipid-signaling molecule involved in regulation of vascular tone, angiogenesis, and ...
Inge Van Bogaert +6 more
doaj +1 more source
Molecules, 2023 One of the most important constituents of the cell membrane is arachidonic acid. Lipids forming part of the cellular membrane can be metabolized in a variety of cellular types of the body by a family of enzymes termed phospholipases: phospholipase A2 ...
Cándido Ortiz-Placín +3 more
doaj +1 more source
PLoS ONE, 2015 ObjectiveTo evaluate human oocyte ability to undergo fertilization and subsequent preimplantation embryonic development in relation to a wide panel of follicular fluid (FF) arachidonic acid derivatives (AAD) and linoleic acid derivatives (LAD) of ...
Przemysław Ciepiela +5 more
doaj +1 more source
Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) [PDF]
, 2013 This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy. ‘This is the peer reviewed version of the following article: Knights, K. M., Rowland, A. and Miners, J. O.
Knights, Kathleen Mary +2 more
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Amniotic fluid 5-hydroxyeicosatetraenoic acid in preterm labor
Prostaglandins, 1988 5-Hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating human uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if preterm labor is associated with changes in the concentration of this metabolite in amniotic fluid.
Romero, Roberto +4 more
openaire +3 more sources