Results 91 to 100 of about 4,998,988 (263)

Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan‐related metabolites for health longevity in centenarians

iMeta, Volume 4, Issue 3, June 2025.
Schematic representation of the design. Tryptophan metabolism is enriched in serum metabolites and gut microbiota of centenarians, potentially contributing to healthy longevity. A key tryptophan metabolite 5‐methoxyindoleacetic acid (5‐MIAA) is linked to the Christensenellaceae R‐7 group and exhibits effects of delaying cell senescence, promoting ...
Xiaorou Qiu, Chao Mu, Jie Hu, Jiaxin Yu, Wenbo Tang, Yueli Liu, Yongmei Huang, Yixian Lu, Peihua Tang, Jingzhen Wu, Zixuan Huang, Xianlin Mei, Huaguo Xiang, Hao Lin, Yi Qi, Hui Luo, Xuemeng Li   +16 more
wiley   +1 more source

Is Amino-Acid Homochirality Due To Asymmetric Photolysis In Space? [PDF]

arXiv, 1999
Amino acids occurring in proteins are, with rare exceptions, exclusively of the L-configuration. Among the many scenarios put forward to explain the origin of this chiral homogeneity (i.e., homochirality), one involves the asymmetric photolysis of amino acids present in space, triggered by circularly polarized UV radiation.
arxiv  

Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3 [PDF]

, 2000
The gene that codes for the ABC transporter ABCG1 is located in a chromosomal susceptibility region (21q22.3) for affective disorders. Genetic variations in ABCG1 have been associated with affective disorders in Japanese males.
Anghelescu, I., Bondy, Brigitta, Dahmen, N., Giegling, Ina, Gietl, A., Möller, Hans-Jürgen, Müller-Siecheneder, F., Rujescu, Dan, Schäfer, M., Szegedi, A.   +9 more
core   +1 more source

Patients with Allan‐Herndon‐Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment

Movement Disorders, Volume 40, Issue 5, Page 938-949, May 2025.
Abstract Background Patients with mutations in the monocarboxylate transporter 8 (MCT8, SLC16A2) suffer from X‐linked recessive Allan‐Herndon‐Dudley syndrome (AHDS), which is characterized by developmental delay and a severe movement disorder. Current trials using thyroid hormone derivatives to overcome the transporter defect have failed to achieve ...
Nina‐Maria Wilpert, Angela L. Hewitt, Roser Pons, Marie‐Thérèse Henke, Andrea Dell'Orco, Martin Bauer, Christiane Grolik, Stephan Menz, Monika Wahle, Annika Zink, Alessandro Prigione, Christina Reinauer, Catharina Lange, Christian Furth, Knut Brockmann, Sabine Jung‐Klawitter, Stine Christ, Angela M. Kaindl, Anna Tietze, Heiko Krude, Thomas Opladen, Markus Schuelke   +21 more
wiley   +1 more source

Are Strong Bronsted Acids Necessarily Strong Lewis Acids? [PDF]

arXiv, 2006
The Broensted and Lowry acid base theory is based on the capacity of proton donation or acceptance (in the presence or absence of a solvent) whereas the Lewis acid base theory is based on the propensity of electron pair acceptance or donation. We explore through DFT calculation the obvious question whether these two theories are in conformity with each
arxiv  

Cerebrospinal Fluid Concentrations of Biogenic Amines: Potential Biomarkers for Diagnosis of Bacterial and Viral Meningitis

Pathogens, 2018
Catecholamine and serotonin are biogenic amines (BAs) that serve as neurotransmitters and play an important role in the regulation of cardinal functions that are mainly altered during central nervous system (CNS) infections.
Aneela Taj, Nusrat Jamil
doaj   +1 more source

Effects of pharmacological treatment on metabolomic alterations in animal models of depression

Translational Psychiatry, 2022
Numerous studies have investigated metabolite alterations resulting from pharmacological treatment in depression models although few quantitative studies explored metabolites exhibiting constant alterations.
Juncai Pu, Yiyun Liu, Siwen Gui, Lu Tian, Yue Yu, Dongfang Wang, Xiaogang Zhong, Weiyi Chen, Xiaopeng Chen, Yue Chen, Xiang Chen, Xue Gong, Lanxiang Liu, Wenxia Li, Haiyang Wang, Peng Xie   +15 more
doaj   +1 more source

European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption

United European Gastroenterology Journal, Volume 13, Issue 4, Page 599-613, May 2025.
ABSTRACT Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac ...
Marco Vincenzo Lenti, Heinz Florian Hammer, Ilja Tacheci, Rosa Burgos, Stephane Schneider, Anastasiou Foteini, Aleksejs Derovs, Jutta Keller, Ilse Broekaert, Marianna Arvanitakis, Dan Lucian Dumitrascu, Oscar Segarra‐Cantón, Željko Krznarić, Juris Pokrotnieks, Gonçalo Nunes, Johann Hammer, Loris Pironi, Marc Sonyi, Cristina Maria Sabo, Juan Mendive, Adrien Nicolau, Jernej Dolinsek, Denisa Kyselova, Lucrezia Laterza, Antonio Gasbarrini, Teodora Surdea‐Blaga, Jorge Fonseca, Christos Lionis, Gino Roberto Corazza, Antonio Di Sabatino   +29 more
wiley   +1 more source

The Factors of the Classification of Protein Amino Acids [PDF]

This paper is published in GLASNIK of Montenegrin Academy of Science and arts, 2000, 13, pp. 173-194, 2006
In this work it is shown that three pairs of the factors appear to be the key, i.e. main factors of a natural classification of protein (canonical) amino acids within the amino acid (genetic) code. First pair: the factors of the habit of an amino acid molecule (size and polarity).
arxiv  

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry

BMC Geriatrics, 2023
Background During biological aging, significant metabolic dysregulation in the central nervous system may lead to cognitive decline and neurodegeneration. However, the metabolomics of the aging process in cerebrospinal fluid (CSF) has not been thoroughly
Fu-Chao Liu, Mei-Ling Cheng, Chi-Jen Lo, Wen-Chuin Hsu, Gigin Lin, Huan-Tang Lin   +5 more
doaj   +1 more source