Mechanism of Opsoclonus-Myoclonus Syndrome
Cerebrospinal fluid measurements of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the dopamine metabolite homovanillic acid (HVA) in samples from 27 children with opsoclonus-myoclonus syndrome and 47 controls are reported from the ...
J Gordon Millichap
doaj +1 more source
Background The cortico-cerebellar-thalamic-cortical circuit has been implicated in the emergence of psychotic symptoms in schizophrenia (SZ). The kynurenine pathway (KP) has been linked to alterations in glutamatergic and monoaminergic neurotransmission ...
Amira Ben Afia +8 more
doaj +1 more source
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. [PDF]
Activation of the nuclear factor \u3baB/c-Rel can increase neuronal resilience to pathological noxae by regulating the expression of pro-survival manganese superoxide dismutase (MnSOD, now known as SOD2) and Bcl-xL genes.
Alghisi M +17 more
core +3 more sources
Spot urinary 5-hydroxyindoleacetic acid is not an ideal diagnostic test for acute appendicitis [PDF]
Background and purpose of the studyThere is growing evidence to suggest the use of urinary 5-hydroxyindoleacetic acid (5-HIAA) test to help with the diagnosis of appendicitis.
Afshin Alijani +24 more
core +2 more sources
Hepatic fibrogenesis requires sympathetic neurotransmitters [PDF]
Background and aims: Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear.
Diehl, AM +11 more
core +2 more sources
Metabolites of Tryptophane and Phenylalanine as Markers of Small Bowel Ischemia-Reperfusion Injury
Ischemic-reperfusion injury of the small intestine is an acute clinical condition with high mortality rate. This study describes the changes in levels of phenylalanine and tryptophan metabolites in intestinal homogenates and urine samples of Wistar male ...
Mašlanková Jana +9 more
doaj +1 more source
Psychopathology and 5-hydroxyindoleacetic acid excretion [PDF]
Abstract Schizophrenics and nonschizophrenics do not differ in urinary excretion of 5-hydroxyindoleacetic acid on either a concentration or 24 h basis, nor do they differ in variability of excretion. Although a pattern was observed of decreasing psychopathology with increasing 5-hydroxyindoleacetic acid excretion, this pattern may be related to ...
openaire +3 more sources
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders [PDF]
Background: Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of ELS, utilizing the variable foraging demand (VFD) macaque model, on adolescent ...
Coplan, Jeremy D. +14 more
core +3 more sources
Difference and Similarity of Serotonin and Pteridines to Act on Lipid Metabolism
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver homogenate, Krebs-Ringer phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol.
Rudzite Vera +5 more
doaj +1 more source
Five boys with Lesch-Nyhan syndrome and varying degrees of dystonia, chorea, spasticity, ataxia, dysarthria, and mental retardation were studied at the Depts of Neurology and Medicine, Baylor College of Medicine, and Depts of Neurology and Pediatrics ...
J Gordon Millichap
doaj +1 more source

