Results 251 to 260 of about 268,094 (306)
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Clindamycin phosphate scavenges hydroxyl radical
International Journal of Dermatology, 2007AbstractBackground Clindamycin phosphate (CLDMP) is effective against Gram‐positive and anaerobic bacteria, and is known to have anti‐inflammatory properties.Methods To further study the anti‐inflammatory properties of CLDMP, we examined the scavenging effects on superoxide anion and hydroxyl radical using an electron spin resonance (ESR) spin ...
Sato E, Kato M, Kohno M, Niwano Y
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Analytical Biochemistry, 1981
Abstract A mixture of xanthine or hypoxanthine and xanthine oxidase generates the superoxide radical, O2 • , and H2O2. In the presence of iron salts, O2 • and H2O2 can interact to produce the hydroxyl radical, OH·. Superoxide-dependent formation of OH· can be measured by its ability to hydroxylate salicylate as followed by an improved ...
R, Richmond +3 more
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Abstract A mixture of xanthine or hypoxanthine and xanthine oxidase generates the superoxide radical, O2 • , and H2O2. In the presence of iron salts, O2 • and H2O2 can interact to produce the hydroxyl radical, OH·. Superoxide-dependent formation of OH· can be measured by its ability to hydroxylate salicylate as followed by an improved ...
R, Richmond +3 more
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Hydroxylation of 3-nitrotyrosine by hydroxyl radical
Chinese Chemical Letters, 2007Abstract Hydroxylation of 3-nitrotyrosine (3-NT) and 3-NT containing peptide Gly-nitroTyr-Gly in aqueous solution by hydroxyl radical were investigated with gamma irradiation. The structures of the hydroxylated products were confirmed by electrospray ionization mass spectrometry and 1 H NMR spectrometry.
Jun Chen Dong +3 more
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Thiol-induced hydroxyl radical formation and scavenger effect of thiocarbamides on hydroxyl radicals
Journal of Inorganic Biochemistry, 1986The effects of thiols and thiocarbamides on hydroxyl radical (.OH) formation by the hypoxanthine(HYP)-xanthine oxidase(XOD)-Fe3+ .EDTA system were investigated in the range of 0.5-5 mM by colorimetrically measuring salicylate hydroxylation. Thiocarbamides powerfully inhibited the hydroxylation while thiols showed a paradoxical effect, enhancing it at ...
N, Motohashi, I, Mori
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Effective Inhibition of Hydroxyl Radicals by Hydroxylated Biphenyl Compounds
Free Radical Research Communications, 1993In aqueous media, approximate rate constants for the reactions between hydroxyl radicals (.OH) and biphenyl compounds such as dehydrodieugenol, magnolol, honokiol, dehydrodidihydroeugenol, dehydrodivanillyl alcohol, and dehydrodicreosol were estimated by competition reactions for .OH between these biphenyls and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO ...
J, Taira +5 more
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DNA footprinting with hydroxyl radical
Nature, 1988High resolution images of proteins bound to DNA can be achieved through the use of a simple inorganic chemical system that produces the hydroxyl radical.
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Addition Radicals Formed by Hydroxyl Radical Bombardment of Uracil
Science, 1966Direct addition of O—H radicals at room temperature to the carbon No. 5 of the uracil ring has been proved by measurement of the proton hyperfine structure in the electron spin resonance of the resulting uracil + O—H radicals. Upon addition of the OH, the H originally bound to carbon No. 5 shifts to No. 6, thus forming a methylene group at carbon No. 6,
Herak, Janko, Gordy, Walter
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Analytical Biochemistry, 2001
Hydroxylation of l-phenylalanine (Phe) by hydroxyl radical (*OH) yields 4-, 3-, and 2-hydroxyl-Phe (para-, meta-, and ortho-tyrosine, respectively). Phe derivative measurements have been employed to detect *OH formation in cells and tissues, however, the specificity of this assay is limited since Phe derivatives also arise from intracellular Phe ...
BIONDI, Roberto +5 more
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Hydroxylation of l-phenylalanine (Phe) by hydroxyl radical (*OH) yields 4-, 3-, and 2-hydroxyl-Phe (para-, meta-, and ortho-tyrosine, respectively). Phe derivative measurements have been employed to detect *OH formation in cells and tissues, however, the specificity of this assay is limited since Phe derivatives also arise from intracellular Phe ...
BIONDI, Roberto +5 more
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Glycol Splitting by Hydroxyl Radicals
Nature, 1946RECENTLY1 I suggested, on theoretical grounds, that the splitting of I±-glycols to aldehydes or ketones by means of lead tetra-acetate was due to dehydrogenation by free acetate radicals.
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Estrogen diminishes postischemic hydroxyl radical production
American Journal of Physiology-Heart and Circulatory Physiology, 1998Reperfusion of blood flow to an ischemic myocardium is imperative to survival; ironically, it may also manifest several pathophysiological conditions. The most important of these are reperfusion arrhythmias and tissue injury and/or death. The mechanisms involved in reperfusion arrhythmias remain to be fully elucidated; however, increasing evidence ...
N A, McHugh, G F, Merrill, S R, Powell
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