Results 121 to 130 of about 8,352 (265)

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Comprehensive study of the possible electrotransformations of the sodium salt of 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate as potential antiviral drug

Chimica Techno Acta
The electrochemical transformation of nitroheterocyclic compounds plays a critical role in understanding their biological activity. Despite structural similarities among nitrotriazolotriazines, their electroreduction mechanisms remain incompletely ...
Polina N. Mozharovskaia, Ivan A. Balin, Alexandra Vs. Ivoilova, Anton N. Tsmokalyuk, Roman A. Drokin, Vladimir L. Rusinov, Alla V. Ivanova, Alisa N. Kozitsina   +7 more
doaj   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

University teaching of mass spectrometry as a key practical technique within the context of a fully integrated, spiral curriculum

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart   +3 more
wiley   +1 more source

Structure and functional genes associated with carbon, nitrogen, phosphorus, and sulfur cycling processes in periphyton: A comparison between natural and artificial rivers

River, EarlyView.
Network analysis of functional genes among prokaryotes, and eukaryotes in natural and artificial rivers. Abstract Periphyton in aquatic ecosystems plays vital roles in the elemental cycle process and is vulnerable to anthropogenic interference. However, few studies have explored the elemental cycles of carbon (C), nitrogen (N), phosphorus (P), and ...
Yulu Tian, Jiezhang Mo, Jiaxin Liu, Chenghao Li, Jiahua Guo   +4 more
wiley   +1 more source

3D‐Printed Crosslinked Nanocellulose‐MXene Hydrogels and Aerogels with High Strength and Conductivity

Small, EarlyView.
This study presents a robust strategy for 3D printing conductive, mechanically resilient MXene–CNF composite structures using a single‐step freeze‐induced crosslinking method. The printed architectures remain stable in both wet and dry states, exhibit high electrical conductivity and mechanical strength, and demonstrate practical application in fully ...
Nuzhet Inci Kilic, Kyle Matthews, Giovanni Marco Saladino, Yury Gogotsi, Per A. Larsson, Mahiar Max Hamedi   +5 more
wiley   +1 more source

Comprehensive Evaluation of Bisphenol A Toxicity Reveals Neurobehavioral, Metabolic, and Reproductive Impairments in Girardia tigrina

Environmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a common industrial chemical used in plastics and consumer products, is increasingly detected in aquatic environments, raising serious concerns about its potential ecological impacts. This study evaluated the sublethal and acute toxic effects of BPA on the freshwater planarian Girardia tigrina, a recognized model for ...
Raquel de Jesus Selestrino, Felipe Schaly, Welligton Luciano Braguini   +2 more
wiley   +1 more source

Methaemoglobinaemia: From pathophysiology to contemporary clinical management

British Journal of Haematology, EarlyView.
Summary Methaemoglobin (MetHb) is an oxidised form of haemoglobin (Hb) unable to bind oxygen. Raised levels of MetHb reduce the blood's oxygen‐carrying capacity, causing potentially severe hypoxaemia and possible death. The condition arises from three main pathologies: mutations in globin genes causing Haemoglobin‐M, inherited deficiency of the enzyme ...
Alexander J. Twine, David C. Rees
wiley   +1 more source