Results 131 to 140 of about 8,352 (265)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Safety assessment of the substance amines, di‐C14‐C20‐alkyl, oxidised, from hydrogenated vegetable oil, for use in food contact materials

EFSA Journal
The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of amines, di‐C14‐C18‐alkyl, oxidised, renamed by the Panel as amines, di‐C14‐C20‐alkyl, oxidised, from hydrogenated vegetable oil.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Andrew Chesson, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Ronan Cariou, Laurence Castle, Emma Di Consiglio, Roland Franz, Maria Rosaria Milana, Eric Barthélémy, Remigio Marano, Gilles Rivière   +24 more
doaj   +1 more source

Delipidisation of wool fibres and the subsequent beneficial properties of delipidised wool fibres

Coloration Technology, EarlyView.
Abstract Wool fibres are complex matrices of proteins and fatty acids/lipids found both internally and externally. 18‐methyleicosanoic acid (18‐MEA) is covalently bound to the surface of the fibre via a thio‐ester link, and is considered one of the most important lipids as it is responsible for the hydrophobic properties of wool fibres.
Jamie A. Hawkes, David M. Lewis
wiley   +1 more source

The Parasitoid Wasp Glyptapanteles porthetriae Induces a Photoperiod‐Dependent Diapause‐Like State in Its Potential Overwintering Host Lasiocampa quercus

Entomologia Experimentalis et Applicata, EarlyView.
We evaluated Lasiocampa quercus as an overwintering host for the koinobiont larval endoparasitoid Glyptapanteles porthetriae by exposing parasitized larvae to different environmental conditions and comparing parasitoid development with that in the primary host Lymantria dispar.
Thomas Zankl, Christa Schafellner
wiley   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Endogenous RALF peptide function is required for powdery mildew host colonization

New Phytologist, EarlyView.
Model of RALF‐FER‐dependent effects on powdery mildew sporulation. Summary The receptor kinase FERONIA (FER) is a susceptibility factor for biotrophic powdery mildew fungal pathogens in Arabidopsis thaliana, but the underlying molecular mechanisms remain largely unknown. FER is required for the perception of endogenous RAPID ALKALINIZATION FACTOR (RALF)
Henriette Leicher, Sebastian D. Schade, Jan W. Huebbers, Kristina S. Munzert‐Eberlein, Genc Haljiti, David Biermann, Athanasios Makris, Xiaoxuan Zhu, Yashank Chauhan, Christina Ludwig, Marion C. Müller, Toshinori Kinoshita, Timo Engelsdorf, Julien Gronnier, Martina K. Ried‐Lasi, Aurélien Boisson‐Dernier, Ralph Hückelhoven, Martin Stegmann   +17 more
wiley   +1 more source

hydroxylamine [PDF]

Chemical & Engineering News Archive, 1951
openaire   +1 more source

PbrIDD2‐PbrAPX14 Module Functions in the Ethylene‐Mediated Ripening and Senescence Process of Pear Fruit

Plant Biotechnology Journal, EarlyView.
ABSTRACT Endogenous H2O2 participated in the ethylene‐dependent ripening and senescence process of horticultural fruit as a secondary messenger; however, the molecular mechanism beneath such a phenomenon has not been fully clarified until recently. By a conjoint analysis of metabolite, enzyme activities, gene expression profiles in AsA‐GSH cycle of ...
Libin Wang, Junpeng Niu, Xiaoyu Tan, Yuhua Xie, Li Jiang, Chen Huan, Xu Zhang, Weiqi Luo, Bing Xie, Xiaopu Ren, Guodong Wang, Yuanyuan Guo, Shaoling Zhang   +12 more
wiley   +1 more source

The SVP–FRO6 Module Integrates the Control of Leaf Senescence and Flowering in Arabidopsis

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants coordinate major developmental transitions by integrating intrinsic genetic programs with environmental signals, where nutrient availability serves as a critical external factor shaping growth and fitness. Iron (Fe), an essential micronutrient for cellular respiration and photosynthesis, is strictly regulated through sophisticated ...
Hyunsu Park, Yeong Seon Yoon, Sanghoon Park, Ukcheol Jeong, Hyeyoung Choi, Hyunwoo Oh, Dovran Shamamedov, Zhonghai Li, Hye Ryun Woo   +8 more
wiley   +1 more source

Drought affects Fe deficiency‐induced responses in a purple durum wheat (Triticum turgidum subsp. durum) genotype

Plant Biology, EarlyView.
Combined Fe deficiency and drought in durum wheat trigger interactive responses: drought suppressed root Fe uptake regardless of Fe availability, and both stresses altered phytosiderophore release, ABA level and Fe transporter gene expression, revealing a trade‐off between water and Fe. Abstract Iron (Fe) is essential for plants and humans, with over 2
G. Quagliata, M. D. G. Molina, G. Mannino, E. Coppa, M. N. Saidi, S. Palombieri, F. Sestili, G. Vigani, S. Astolfi   +8 more
wiley   +1 more source