Results 161 to 170 of about 66,526 (244)

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non-Canonical Heme Enzyme. [PDF]

Adv Sci (Weinh)
Sun Y, Dou C, Yan W, Chen P, Zhang L, Zhou D, Zheng Y, Long Z, Li S, Xu X, Huang Q, Zhu X, Cheng W.   +12 more
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Structure-based modeling reveals molecular basis for CYP153A6's novel activity toward toluene derivatives. [PDF]

Sci Rep
Wei Y, Donzella S, Foiadelli S, Molinari F, Guerrini U, Eberini I.   +5 more
europepmc   +1 more source

Rethinking the role of HIF in hepatocellular carcinoma

The FEBS Journal, EarlyView.
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth, Michael Batie, Sonia Rocha   +2 more
wiley   +1 more source

Engineering Pseudomonas taiwanensis VLB120 for regio- and stereospecific hydroxylation of L-lysine fueled by the Weimberg pathway. [PDF]

Microb Cell Fact
Nerke P, Handke J, Hubmann G, Lütz S.
europepmc   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Pd-Catalyzed Hydroxylation of Aryl Halides under Air and in Eco-Friendly Solvent. [PDF]

ACS Omega
Jones GA, Beshara M, Levin JE, Garcevic AR, Rosiles-Dueñas DG, Saleh YA, Schultz EE.   +6 more
europepmc   +1 more source

Mechanisms underlying the protective effects of San‐Bai decoction against UV radiation on the skin

International Journal of Cosmetic Science, EarlyView.
Combining conventional differential expression analysis with differential network analysis offers a promising strategy to uncover the mechanistic basis of the holistic benefits provided by herbal blends. Our findings demonstrated that San‐Bai decoction modulates multiple pathways—not only those related to skin pigmentation, such as ET‐1 signalling, but
Rui Zhang, Hong Zhang, Chengming Zhang, Wencai Jiang, Luonan Chen, Yimei Tan, Ying Zou, Xuelan Gu   +7 more
wiley   +1 more source

Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305. [PDF]

Rapid Commun Mass Spectrom
Kobidze G, Möller T, Wen HC, Busardò FP, Thevis M.   +4 more
europepmc   +1 more source

Drivers of strigolactone diversity: P450s in strigolactone biosynthesis

Journal of Integrative Plant Biology, EarlyView.
This review summarizes the discovery and functional identification of cytochrome P450 in strigolactone biosynthesis, classifies and summarizes the members discovered so far, clarifies their biological significance, discusses the technology of strigolactone synthesis research, and finally describes some problems in strigolactone research and potential ...
Changbin Niu, Harro J. Bouwmeester, Changsheng Li   +2 more
wiley   +1 more source