A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T [PDF]
, 2012 BACKGROUND: Natrialba magadii is an aerobic chemoorganotrophic member of the Euryarchaeota and is a dual extremophile requiring alkaline conditions and hypersalinity for optimal growth. The genome sequence of Nab.
Diego E Sastre +15 more
core +2 more sources
Genetic Markers of Postmortem Brain Iron
Journal of Neurochemistry, Volume 169, Issue 2, February 2025.Iron is essential for neural development and physiology but also catalyzes oxidative damage implicated in neurodegeneration. We performed a genome‐wide association study of postmortem brain iron. Promising loci were followed up for replication and mapped to genes for cortical transcriptomic and epigenetic analysis.
Marilyn C. Cornelis +4 more
wiley +1 more source
Identification and Validation of Housekeeping Genes for Gene Expression Analysis of Cancer Stem Cells. [PDF]
PLoS ONE, 2016 The characterization of cancer stem cell (CSC) subpopulation, through the comparison of the gene expression signature in respect to the native cancer cells, is particularly important for the identification of novel and more effective anticancer ...
Silvia Lemma +4 more
doaj +1 more source
Myocyte enhancer factor 2C: an osteoblast transcription factor identified by DMSO enhanced mineralization [PDF]
, 2011 Free to read on publisher website Rapid mineralization of cultured osteoblasts could be a useful characteristic in stem-cell mediated therapies for fracture and other orthopaedic problems. Dimethyl sulfoxide (DMSO) is a small amphipathic solvent molecule
Bacic-Welsh, Desa +6 more
core +2 more sources
Plant Biotechnology Journal, Volume 23, Issue 2, Page 592-614, February 2025.Summary Pigments, as coloured secondary metabolites, endow the world with a rich palette of colours. They primarily originate from plants and microorganisms and play crucial roles in their survival and adaptation processes. In this article, we categorize pigments based on their chemical structure into flavonoids, carotenoids, pyrroles, quinones ...
Qian Tang +4 more
wiley +1 more source
Systematically Analyzing the Pathogenic Variations for Acute Intermittent Porphyria
Frontiers in Pharmacology, 2019 The rare autosomal dominant disorder acute intermittent porphyria (AIP) is caused by the deficient activity of hydroxymethylbilane synthase (HMBS).
Yibao Fu +11 more
doaj +1 more source
A method to correlate mRNA expression datasets obtained from fresh frozen and formalin-fixed, paraffin-embedded tissue samples: A matter of thresholds [PDF]
, 2015 Background: Gene expression profiling of tumors is a successful tool for the discovery of new cancer biomarkers and potential targets for the development of new therapeutic strategies.
Foekens, J.A. (John) +8 more
core +1 more source
Molecular and Cellular Probes, 1998 The hydroxymethylbilane synthase (HMBS) mRNAs from 44 control individuals and 30 patients suffering from acute intermittent porphyria (AIP), were screened for length differences by reverse transcriptase polymerase chain reaction (RT-PCR) and any abnormalities were characterized by direct sequencing.
Ong, PML +3 more
openaire +3 more sources
Incubation temperature affects type X collagen expression in embryonic ducks [PDF]
, 2014 Optimal temperature regulation is an important component of avian incubation and the process of embryonic development can be accelerated by even small increases in incubation temperature.
Prickett, Amanda L.
core
Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution. [PDF]
, 2014 The enzyme porphobilinogen deaminase (PBGD; hydroxymethylbilane synthase; EC 2.5.1.61) catalyses an early step of the tetrapyrrole-biosynthesis pathway in which four molecules of the monopyrrole porphobilinogen are condensed to form a linear tetrapyrrole.
Akhtar, M +8 more
core +1 more source