Results 81 to 90 of about 13,094 (219)

Clustering cliques for graph-based summarization of the biomedical research literature [PDF]

, 2013
BACKGROUND: Graph-based notions are increasingly used in biomedical data mining and knowledge discovery tasks. In this paper, we present a clique-clustering method to automatically summarize graphs of semantic predications produced from PubMed citations (
A Naud, A Nenkova, A Ozgür, A Pons-Porrata, AR Aronson, AT McCray, AT McCray, Bartlomiej Wilkowski, C Wartena, Dongwook Shin, F Lerch, G Erkan, G Liu, GC Stein, H Kilicoglu, H Kilicoglu, H Yu, H Zhang, Han Zhang, I Mani, I Yoo, J Ah-Pine, J Goodwin, J Yang, JB Kruskal, K Sparck Jones, KW Boyack, L Smith, LH Reeve, LH Reeve, M Bundschus, M Fiszman, M Fiszman, M Kan, M Lee, Marcelo Fiszman, MG Everett, MJ Norusis, O Bodenreider, P Langfelder, P Tan, PJ Rousseeuw, R Mihalcea, SP Borgatti, T Matsunage, TC Rindflesch, TC Rindflesch, Thomas C Rindflesch, V an der Spek P, Klusener S, V Batagelj, VD Blondel, X Liu, X Zhang, Y Yamamoto   +53 more
core   +2 more sources

Statin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Statins are cholesterol‐lowering drugs widely prescribed for preventing cardiovascular diseases. They may cause adverse effects on skeletal muscle, but it remains unclear whether they affect muscle function and mass. We aimed to evaluate the association between statin use and muscle function and mass, and whether the pharmacogenomic
Mélissa Gentreau, Mahitab Sakr, Salahuddin Mohammad, Ahmed M. Alsehli, Olga E. Titova, Gull Rukh, Helgi B. Schiöth   +6 more
wiley   +1 more source

Comparative Efficacy of Initial Statin and Ezetimibe Combination versus Statin Monotherapy on Cardiovascular Outcomes in Diabetes Mellitus: A Nationwide Cohort Study [PDF]

Diabetes & Metabolism Journal
Background This study aimed to assess the efficacy of an initial combination therapy of statin and ezetimibe compared with statin monotherapy on major cardiovascular outcomes in individuals with diabetes.
Minji Sohn, Young-Hwan Park, Soo Lim
doaj   +1 more source

Update on statin-mediated anti-inflammatory activities in atherosclerosis [PDF]

, 2018
Anti-inflammatory activities of statins in atherosclerosis have been well documented by both basic research and clinical studies. Statins have been introduced in the 1980s as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors to block cholesterol
Mach, François, Montecucco, Fabrizio
core  

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury [PDF]

, 2013
Background: Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure.
A Linder, Cecilia M O’Kane, Daniel F McAuley, DF McAuley, DG Sinclair, G Weitz-Schmidt, H Herwald, H Sengelov, H Tapper, Heiko Herwald, J Grommes, JR Jacobson, K Tsushima, Karim Dib, KP Steinberg, M Shyamsundar, MB Fessler, MS Chew, MS Diamond, Murali Shyamsundar, N Gautam, O Soehnlein, O Soehnlein, S Steiner, S Zhang, Thelma R Craig, TR Craig, WM Shafer   +27 more
core   +1 more source

Genetic variants linked to statin‐associated Type 2 diabetes mellitus: Findings from the UK Biobank and the All of Us Research Program

British Journal of Pharmacology, Volume 182, Issue 23, Page 5803-5813, December 2025.
Background and Purpose Statins are widely prescribed for the prevention of cardiovascular disease, yet recent studies suggest an increased risk of new‐onset Type 2 diabetes mellitus. This study aimed to identify genetic variants associated with statin‐associated new‐onset Type 2 diabetes mellitus from the UK Biobank and All of Us.
Yoon‐A Park, Da Hoon Lee, Jung Sun Kim, Jeong Yee, Hye Sun Gwak   +4 more
wiley   +1 more source

Short-Term Therapy with High Dose Atorvastatin in Patients with Coronary Artery Disease Can Reduce Inflammatory Process [PDF]

Acta Medica Iranica, 2010
Coronary heart disease is the leading cause of death and disability in adults. The association between acute coronary syndrom (ACS) and elevated serum high sensitivity c-reactive protein (hsCRP) suggests that chronic inflammation of the coronary arterial
Vida Nesar Hossein, Keivan Yosef Nejad, Fatemeh Abdollahian   +2 more
doaj   +1 more source

Evaluation the effects of red yeast rice in combination with statin on lipid profile and inflammatory indices; a randomized clinical trial

BMC Nutrition, 2022
Background Dyslipidemia is a prominent cause of cardiovascular disease as it leads to inflammation and plaque deposition within arteries. Treatment includes lifestyle modifications and lipid-lowering medications.
Ali Tavan, Saam Noroozi, Bardia Zamiri, Reza Gholchin Vafa, Mohammadhossein Rahmani, Mohammadjavad Mehdizadeh Parizi, Amin Ahmadi, Reza Heydarzade, Mohammad Montaseri, Seyed Ali Hosseini, Javad Kojuri   +10 more
doaj   +1 more source

Las estatinas en el tratamiento de la enfermedad del alzheimer [PDF]

, 2016
La enfermedad de Alzheimer es el tipo más común de demencia y su prevalencia se ha incrementado significativamente en los últimos años. Se trata de una enfermedad neurodegenerativa que ocasiona una gran preocupación en la sociedad, debido al grave ...
Mejías Trueba, Marta
core  

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation [PDF]

, 2018
Different immune activation states require distinct metabolic features and activities in immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response ...
Angiari, Stefano, Carroll, Richard G., Galván-Peña, Silvia, Koppe, Emma L., Modis, Louise K., O'Neill, Luke A., Sévin, Daniel C., Triantafilou, Kathy, Triantafilou, Martha, Zaslona, Zbigniew   +9 more
core   +2 more sources