Antimicrobial Potential of Hydroxymethylglutaryl-Coa Reductases Inhibitors [PDF]
The 1st International Electronic Conference on Clinical Medicine, 2021 : This study proposes the contemplation of an ecumenical scenario on the antimicrobial potential of statins, based on a scientific narrative review, providing subsidies for research and possibilities in the face of this public health problem. To start the
Hélida Maravilha Dantas e Sousa Almeida +2 more
semanticscholar +3 more sources
Integrative Transcriptomic and Target Metabolite Analysis as a New Tool for Designing Metabolic Engineering in Yeast [PDF]
BiomoleculesPrecision fermentation processes, especially when using edited microorganisms, demand accuracy in the bioengineering process to maximize the desired outcome and to avoid adverse effects.
Alejandro Lopez-Barbera +4 more
doaj +3 more sources
Tomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening. [PDF]
The Plant Cell, 1989 The activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and the level of its mRNA have been determined at various stages of tomato fruit development. The HMGR reaction makes mevalonate, a necessary component in the synthesis of all isoprene containing compounds, such as sterols and carotenoids.
Jonathon O. Narita, Wilhelm Gruissem
semanticscholar +5 more sources
Molecular Dynamic Simulation of Hydroxymethylglutaryl-CoA Reductase Inhibitors from Gnetum gnemon L. Seed Extract [PDF]
Pharmacognosy Journal, 2018 Objective: Gnetum gnemon L. (melinjo) seed extract contained trans-resveratrol which has been shown to inhibit hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Therefore it has a potent activity for lowering blood cholesterol. This study was carried out to determine the molecular dynamics simulation of HMG-CoA reductase inhibitors from Gnetum gnemon L ...
Yuditya Artha +3 more
semanticscholar +3 more sources
Crystal Structure of a Statin Bound to a Class II Hydroxymethylglutaryl-CoA Reductase
Journal of Biological Chemistry, 2003 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the primary target in the current clinical treatment of hypercholesterolemias with specific inhibitors of the "statin" family. Statins are excellent inhibitors of the class I (human) enzyme but relatively poor inhibitors of the class II enzymes of important bacterial pathogens.
Lydia Tabernero +2 more
semanticscholar +4 more sources
A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts [PDF]
FEMS Microbiology Letters, 1995 Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary ...
Nina Gunde‐Cimerman +2 more
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Inactivation of hydroxymethylglutaryl-CoA reductase from yeast by coenzyme A disulfide.
Journal of Biological Chemistry, 1981 The time-dependent inactivation of hydroxymethylglutaryl-CoA reductase from yeast by solutions of hydroxymethylglutaryl-CoA and CoASH is due to the rapid inactivation of the enzyme by oxidized CoA (CoA disulfide) present at trace levels in solutions of hydroxymethylglutaryl-CoA and CoASH.
Hiram Gilbert, Mikaela D. Stewart
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Regulation of hydroxymethylglutaryl-CoA reductase in rat leukocytes
Journal of Lipid Research, 1977 Methods were developed for the assay of hydroxymethylglutaryl-CoA reductase (NADPH) activity in microsomes from rat leukocytes. The activity in freshly isolated leukocytes is low compared to rat liver but can be assayed reliably. The patterns of response of leukocyte reductase in the assay to variation in substrate concentration, protein concentration,
Nicolas L. Young, Victor W. Rodwell
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Phosphite inhibits <i>Phytophthora cinnamomi</i> by downregulating oxidoreductases and disrupting energy metabolism. [PDF]
Front MicrobiolPhytophthora root rot caused by the hemibiotrophic oomycete, Phytophthora cinnamomi is a major biotic hindrance in meeting the ever-increasing demand for avocados.
Prabhu SA +7 more
europepmc +3 more sources
Statins: a tale of two pathways—cardiovascular savior, renal ineffectual [PDF]
Precision and Future MedicineStatins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives.
Jihyun Yang
doaj +3 more sources