Results 161 to 170 of about 21,088 (210)

Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study. [PDF]

BMC Cancer
Li J, Yang Z, Wang T, Li M, Wu X, Fu X, Yang C, Li Y, Wang X, Lan Z, Li M, Chen S.   +11 more
europepmc   +1 more source

Charantin targets HMGCR-PCSK9 axis and activates PPAR-α signaling to ameliorate hyperlipidemia: Mechanistic insights from bioinformatics and in-vivo studies. [PDF]

PLoS One
Abbas G, Malik MNH, Yasin H, Alshammari SO, Murtaza G, Hassan W, Atif M, Shabbir R.   +7 more
europepmc   +1 more source

Pharmacophore Modeling and Binding Affinity of Secondary Metabolites from Angelica keiskei to HMG Co-A Reductase. [PDF]

Molecules
Aulifa DL, Amirah SR, Rahayu D, Megantara S, Muchtaridi M.   +4 more
europepmc   +1 more source

Synthesis of Caged HMG-CoA Reductase Substrates for the Elucidation of Cellular Pathways. [PDF]

J Org Chem
O'Connell RJ, Dolphin NJ, Ferraudi G, Lee M, Stauffacher CV, Helquist P, Wiest O.   +6 more
europepmc   +1 more source

Case report: Rapid clinical improvement of anti-HMGCR immune-mediated necrotizing myopathy treated with efgartigimod. [PDF]

Front Immunol
Zeng Q, Chen K, Zeng L, Xu L, Tan S.
europepmc   +1 more source

Drug Target Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Atrial Fibrillation.

Cardiology
Li F, Mei Y, Wu Q, Wu X.
europepmc   +1 more source

Expression of the cholesterol transporter SR-B1 in melanoma cells facilitates inflammatory signaling leading to reduced cholesterol synthesis. [PDF]

Neoplasia
Eckel O, Mirea MA, Gschwendtner A, Pistek M, Kinslechner K, Röhrl C, Stangl H, Hengstschläger M, Mikula M.   +8 more
europepmc   +1 more source

Assessing the effects of HMGCR, LPL, and PCSK9 inhibition on sleep apnea: Mendelian randomization analysis of drug targets. [PDF]

Medicine (Baltimore)
Tan W, Deng X, Tan X, Tan G.
europepmc   +1 more source

Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast

Applied Microbiology and Biotechnology, 1998
The enzyme 3-hydroxy-3-methylglutaryl-co-enzyme-A (HMG-CoA) reductase is known as the rate limiting enzyme in early sterol biosynthesis in eukaryotic cells. To eliminate this regulation in the yeast Saccharomyces cerevisiae, a truncated HMG1 gene, producing a form of the enzyme that lacks the membrane-binding region (i.e.
Thomas Polakowski, U. Ståhl, Christine Lang   +2 more
semanticscholar   +4 more sources

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The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

Letters in Drug Design & Discovery, 2019
High cholesterol and triglyceride levels are mainly related to further generation of lifethreating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
ERDOĞAN ORHAN, İLKAY, Gulcan, Hayrettin Ozan, Yigitkan, Serkan   +2 more
openaire   +3 more sources