Results 11 to 20 of about 21,088 (210)

Dietary Coenzyme Q10 Suppressed Hepatic Hydroxymethylglutaryl-CoA Reductase Activity in Laying Hens [PDF]

Bioscience, Biotechnology, and Biochemistry, 2013
The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn ...
Kazuhisa Honda, Takaoki Saneyasu, Tohru Motoki, Yuriko PARK, Hiroshi Kamisoyama   +4 more
semanticscholar   +4 more sources

Regulation of Macrophage Cholesterol Efflux through Hydroxymethylglutaryl-CoA Reductase Inhibition [PDF]

Journal of Biological Chemistry, 2005
The cholesterol biosynthetic pathway produces numerous signaling molecules. Oxysterols through liver X receptor (LXR) activation regulate cholesterol efflux, whereas the non-sterol mevalonate metabolite, geranylgeranyl pyrophosphate (GGPP), was recently ...
Carmen Argmann, Jane Y. Edwards, Cynthia G. Sawyez, Caroline O’Neil, Robert A. Hegele, J. Geoffrey Pickering, Murray W. Huff   +6 more
semanticscholar   +4 more sources

Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system.

Journal of Biological Chemistry, 1981
Thomas S. Ingebritsen, Richard Parker, D. M. Gibson   +2 more
semanticscholar   +4 more sources

Interconversion of active and inactive forms of rat liver hydroxymethylglutaryl-CoA reductase.

Journal of Biological Chemistry, 1977
Jeffrey L. Nordstrom, V.W. Rodwell, Jonathan J. Mitschelen   +2 more
semanticscholar   +4 more sources

Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults—Authors’ reply [PDF]

Clinical Microbiology and Infection, 2019
Barak Pertzov, Noa Eliakim‐Raz, Hani Atamna, Anca Zalmanovici Trestioreanu, Dafna Yahav, L. Leibovici   +5 more
semanticscholar   +4 more sources

Indirect Assessment of Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity in Liver Tissue

Clinical Chemistry, 1975
Abstract We describe an indirect method for assessing variation in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (NADPH) activity in liver tissue. 3-Hydroxy-3-methylglutaryl-CoA and mevalonate concentrations in the tissue homogenate are estimated in terms of absorbances and the ratio between the two is taken as an index of activity of ...
A V, Rao, S, Ramakrishnan
openaire   +3 more sources

In Silico Characterization of Withania coagulans Bioactive Compounds as Potential Inhibitors of Hydroxymethylglutaryl (HMG-CoA) Reductase of Mus musculus

ACS Omega, 2023
Hypercholesterolemia is a mediator for the etiology of cardiovascular diseases, which are characterized as the global leading cause of mortality.
Muhammad Bilal Azmi, Fearoz Khan, Uzma Asif, Beenish Khurshid, Abdul Wadood, Shamim Akhtar Qureshi, Syed Danish Haseen Ahmed, Hina Akram Mudassir, Sadia Ikhlaque Sheikh, Nazia Feroz   +9 more
openalex   +2 more sources

Hydroxymethylglutaryl CoA Reductase

The Journal of Japan Atherosclerosis Society, 1996
Yoshio Tsujita
openalex   +3 more sources

Inhibition of yeast hydroxymethylglutaryl‐CoA reductase by a rat liver mitochondrial preparation [PDF]

FEBS Letters, 1974
C. Madhosingh, B. B. Migicovsky, Irene Wood   +2 more
openalex   +4 more sources

Effects of pravastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, on two human tumour cell lines

Journal of Cancer Research and Clinical Oncology, 1995
Competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase are currently used to treat patients with hypercholesterolaemia. These inhibitors affect not only cholesterol biosynthesis, but also the production of non-steroidal mevalonate derivatives, that are involved in a number of growth-regulatory processes.
Angelika Gebhardt, Axel Niendorf
openalex   +4 more sources