Results 31 to 40 of about 21,088 (210)

Polyphenols from citrus tacle® extract endowed with hmgcr inhibitory activity: An antihypercholesterolemia natural remedy [PDF]

, 2021
Tacle® is a citrus fruit obtained from the crossbreeding of Clementine and Tarocco cultivars. This fruit retains a promising nutraceutical potential most likely due to a high content in polyphenols, among which the main constituents are the two ...
Garofalo A., Grande F., Ioele G., Occhiuzzi M.A., Perri M.R., Rizzuti B., Statti G.   +6 more
core   +1 more source

Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction

Journal of The American Geriatrics Society, 2006
JoAnne M. Foody, Saif S. Rathore, Deron Galusha, Frederick A. Masoudi, Edward P. Havranek, Martha J. Radford, Harlan M. Krumholz   +6 more
openalex   +2 more sources

Applying asymptotic methods to synthetic biology: modelling the reaction kinetics of the mevalonate pathway [PDF]

, 2016
The mevalonate pathway is normally found in eukaryotes, and allows for the production of isoprenoids, a useful class of organic compounds. This pathway has been successfully introduced to Escherichia coli, enabling a biosynthetic production route for ...
Dalwadi, Mohit P., Garavaglia, Marco, King, John R., Minton, Nigel P., Webb, Joseph P.   +4 more
core   +7 more sources

Challenges in the heterologous production of furanocoumarins in Escherichia coli [PDF]

, 2022
Coumarins and furanocoumarins are plant secondary metabolites with known biological activities. As they are present in low amounts in plants, their heterologous production emerged as a more sustainable and efficient approach to plant extraction. Although
Gomes, Daniela Filipa Correia, Rodrigues, Joana Lúcia Lima Correia, Rodrigues, L. R.   +2 more
core   +1 more source

Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. [PDF]

, 2001
Enlarged fat cells exhibit modified metabolic capacities, which could be involved in the metabolic complications of obesity at the whole body level. We show here that sterol regulatory element-binding protein 2 (SREBP-2) and its target genes are induced ...
C. Farnier, I. Dugail, I. Lefrère, P. Ferré, R. Bazin, S. Krief, S. Le Lay, X. Le Liepvre   +7 more
core   +2 more sources

In-silico studies of HMG-Co A reductase inhibitors present in fruits of Withania coagulans Dunal (Solanaceae) [PDF]

, 2020
Purpose: To evaluate the antihypercholesterolemic effect of chemical constituents of W. coagulans by determining inhibitory effect of the compounds against HMG-CoA reductase, using in-silico methods.
Lateef, Tooba, Naeem, Sadaf, Qureshi, Shamim A.   +2 more
core   +2 more sources

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae [PDF]

, 2013
Isoprenoids denote the largest group of chemicals in the plant kingdom and are employed for a wide range of applications in the food and pharmaceutical industry.
Ajikumar, Asadollahi, Basson, Boghigian, Bohlmann, Chang, Chappell, Cheng, Christensen, Collins, Croteau, Da Silva, Daum, Dugar, Dunlop, Engels, Farhi, Faulkner, Greenhagen, Harvey, Hong, Hu, Huang, Hui, Kampranis, Katsuki, Keasling, Kim, Kim, Krivoruchko, Lange, Lees, Li, Lurie, Lynen, Lücker, Mannan, Meigs, Michereff, Muramatsu, Murray, Murugesan, Naigre, Nielsen, Ohto, Oliveira, Oud, Pare, Partow, Parveen, Peralta-Yahya, Rohmer, Rude, Scalcinati, Scalcinati, Schiff, Sharon-Asa, Shearer, Song, Takahashi, Tracy, Tsuruta, Tu, Uribe, Wang, Wang, Wang, Westfall, Wilson, Yoshikuni, Zhang   +70 more
core   +2 more sources

Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways [PDF]

, 2014
Mupirocin, a clinically important antibiotic produced via a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens, consists of a mixture of mainly pseudomonic acids A, B, and C.
Cox, Russell J., Crump, Matthew P., Gao, Shu Shan, Hothersall, Joanne, Murphy, Annabel C., Simpson, Thomas J., Song, Zhongshu, Stephens, Elton R., Thomas, Christopher, Thomas, Christopher M., Willis, Christine L., Wu, Ji'En   +11 more
core   +1 more source

Effect of Insulin on Sterol and Fatty Acid Synthesis and Hydroxymethylglutaryl CoA Reductase Activity in Mammalian Cells Grown in Culture

Proceedings of the National Academy of Sciences of the United States of America, 1974
Sam J. Bhathena, Joel Avigan, Marta E. Schreiner   +2 more
openalex   +3 more sources

Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq. [PDF]

, 2015
Polyketides represent an important class of bioactive natural products with a broad range of biological activities. We identified recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the biosynthesis of the ...
Leeper, Finian J, Matilla, Miguel A, Salmond, George PC   +2 more
core   +2 more sources