Results 51 to 60 of about 21,088 (210)

Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae [PDF]

, 2006
Industrial biotechnology employs the controlled use of microorganisms for the production of synthetic chemicals or simple biomass that can further be used in a diverse array of applications that span the pharmaceutical, chemical and nutraceutical ...
Chemler, Joseph A, Koffas, Mattheos AG, Yan, Yajun   +2 more
core   +3 more sources

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, EarlyView.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

Current Trends, Future Prospects and Constraints of Whole Microalgae and Their Fractions as a Functional Feed Ingredient for Animals

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Microalgae are a highly diverse group of unicellular organisms that grow in a wide range of aquatic environments and are widely used as dietary supplements for both human and animal applications. Microalgae are rich in lipids, proteins, carbohydrates and other valuable bioactive components such as pigments, antioxidants and vitamins.
Sietse Jan Koopmans, Simon Roques, Edoardo Zaccaria, Annemarie Mens, Soumya Kanti Kar   +4 more
wiley   +1 more source

Rosuvastatin in Combination With Bortezomib Promotes Osteogenesis in Myeloma Bone Disease by Inhibiting the Secretion of CCL3

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu, Mingxu Hui, Fan Yang, Bo Huang, Nian Liu, Yuchan He, Xiaotao Wang   +6 more
wiley   +1 more source

Rethinking Statin Dosage in Coronary Disease

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Simon B. Dimmitt, Hans G. Stampfer, Michael C. Kennedy, Jennifer H. Martin   +3 more
wiley   +1 more source

Laboratory tests and clinical significance of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibody

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibody is a newly recognized autoantibody, which is associated with the use of statins and is considered as an immunological marker of necrotizing autoimmune myopathy (NAM).
Jing-jing LUO, Feng GAO, Jie-xi WEN, Hong-jun HAO, Jing GUO, Yi-ning HUANG   +5 more
doaj  

A Unique Regulator Contributes to Quorum Sensing and Virulence in Burkholderia cenocepacia [PDF]

, 2012
Burkholderia cenocepacia causes chronic and life-threatening respiratory infections in immunocompromized people. The B. cenocepacia N-acyl-homoserine lactone (AHL)-dependent quorum sensing system relies on the production of AHLs by the synthases CepI and
A Baldwin, A Edwards, A Gotschlich, A Isles, A Marchler-Bauer, AC Vergunst, AM Jones, AV Patankar, B Huber, B Huber, B Huber, B Subsin, BW Holloway, C Aguilar, C Kooi, CD Sibley, CE Chambers, CL Weingart, CR Corbett, DH Figurski, DP Speert, Duber F. Viteri, E Mahenthiralingam, E Mahenthiralingam, Eoin P. O'Grady, EP O'Grady, EP O'Grady, F Ausubel, HA Cash, HP Schweizer, J Kim, J Lamothe, J Sambrook, J Zhu, Jamunarani Vadivelu, JJ Dennis, K Duan, K Riedel, KA Coggan, KL Tomlin, L Eberl, M Frederix, M Hedl, M Kothe, M Magalhaes, ME Kovach, MW Tan, P Williams, PA Sokol, PA Sokol, Pamela A. Sokol, PS Dehal, R Daniels, RJ Malott, RJ Malott, RP Ryan, RS Flannagan, S Brenner, S Lewenza, S Lewenza, S Lewenza, S Rozen, S Subramoni, S Subramoni, S Uehlinger, SA Loutet, SA McKeon, SP Bernier, SP Bernier, SP Bernier, TD Schmittgen, V Venturi, VL Miller, WL Ng, Y Wei   +74 more
core   +2 more sources

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, Volume 13, Issue 6, 30 January 2026.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza [PDF]

Terpenoids are the largest class of plant secondary metabolites and have attracted widespread interest. Salvia miltiorrhiza, belonging to the largest and most widely distributed genus in the mint family, is a model medicinal plant with great economic and
Altschul, Bin Wu, Bjellqvist, Bohlmann, Botella-Pavia, Bouvier, Bozin, Burge, Burke, Burke, Chang, Chappell, Chen, Cheng, Choi, Cordoba, Cui, Dai, De Martino, Emanuelsson, Engprasert, Estevez, Finn, Friesen, Gao, Ge, Gershenzon, Guo, Ha, Hall, Honda, Hsieh, Kai, Kai, Krogh, Lange, Lange, Laule, Li, Liao, Liao, Lichai Yuan, Lluch, Lombard, Munro, Murashige, Okada, Phillips, Ramos-Valdivia, Ramsay, Reumann, Riou, Rohdich, Rozen, Sando, Sando, Sapir-Mir, Shanfa Lu, Shilin Chen, Simkin, Tamura, Tholl, Thompson, van Schie, Walter, Wang, Wang, Wang, Wang, Wu, Xian’en Li, Xu, Yimian Ma, Yousefzadi, Zhang, Zulak   +75 more
core   +2 more sources

Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi, Jin‐Seok Jung, Yie‐sung Seo, Sungmin Song, Jeehye Ham, Hannah Chung, Yousef Ramadan, Kangchan Choi   +7 more
wiley   +1 more source